Abstract: Provided are antibodies or antigen binding fragments thereof, which can bind to human IL-1?, block the binding of IL-1? to receptors thereof and thereby down regulate the activity of IL-1?, and can be used to prepare drugs for the treatment of immune diseases mediated by IL-1? overexpression such as arthritis, osteoporosis, and tumor necrosis factor receptor-associated periodic syndrome.

Abstract: The present invention belongs to the field of tumor treatment and molecular immunology, and specifically relates to a therapeutic combination and use thereof. Specifically, the therapeutic combination comprises an anti-CTLA4-anti-PD-1 bispecific antibody and an anti-PD-1-anti-VEGFA bispecific antibody. The therapeutic combination of the present invention can effectively treat or prevent a tumor and has good application prospects.

Abstract: An ultrasonic-resilience value testing apparatus for an inorganic non-metal plate, including: a fixing mechanism, a testing mechanism and a control mechanism. The fixing mechanism is for carrying and fixing an inorganic non-metal plate to be tested; the testing mechanism is for performing ultrasonic-resilience value testing on the inorganic non-metal plate fixed on the fixing mechanism; and the control mechanism is in communication connection to the fixing mechanism and the testing mechanism, and is for controlling the fixing mechanism and the testing mechanism to run. By setting the fixing mechanism, problems such as slipping, angle deviation, vibration or movement and damage to the test sample are avoided. By setting the testing mechanism for the resilience value testing, the phenomenon that the relevant mechanical properties of the test sample cannot be accurately reflected since a resilience angle, a velocity and the like are affected by human factors, is improved.

Abstract: The present invention relates to a cyclic peptide, its use in the treatment, amelioration or prevention of a disease caused by antibodies targeting the thyrotropin-TSH receptor (TSHR) in the thyroid gland, in particular Graves' disease and orbitopathy, and to pharmaceutical compositions comprising the same.

Abstract: The present invention relates to short cyclic peptides, their use in the treatment, amelioration or prevention of a disease caused by antibodies targeting the thyrotropin-TSH receptor (TSHR) in the thyroid gland, in particular Graves' disease and orbitopathy, and to pharmaceutical compositions comprising the same.

Abstract: The present invention relates to a cyclic peptide, its use in the treatment, amelioration or prevention of a disease caused by antibodies targeting the thyrotropin-TSH receptor (TSHR) in the thyroid gland, in particular Graves' disease and orbitopathy, and to pharmaceutical compositions comprising the same.

Abstract: A vane for dynamic flow angle measurements may have improved performance for time lag responsiveness over a prior art delta-shaped vane. In various embodiments, a gust sensing vane may have a cropped-delta shape and configured to align to a fluid flow direction, where the gust sensing vane comprises a forward portion having a leading edge and an aft portion having a first trailing edge and a second trailing edge. A cross-sectional area of the forward portion may have a triangular shape. Furthermore, a cross-sectional area of the aft portion has two substantially parallel sides to form the cropped-delta shape of the gust sensing vane. The gust sensing vane may be coupled to, and extend away from, a rotary hub.

Abstract: A vane for dynamic flow angle measurements may have improved performance for time lag responsiveness over a prior art delta-shaped vane. In various embodiments, a gust sensing vane may have a cropped-delta shape and configured to align to a fluid flow direction, where the gust sensing vane comprises a forward portion having a leading edge and an aft portion having a first trailing edge and a second trailing edge. A cross-sectional area of the forward portion may have a triangular shape. Furthermore, a cross-sectional area of the aft portion has two substantially parallel sides to form the cropped-delta shape of the gust sensing vane. The gust sensing vane may be coupled to, and extend away from, a rotary hub.

Abstract: A differential voltage signal (LVDS) driver circuit and/or a Current Mode Logic (CML) driver circuit. The circuit includes two current switches, each coupled to a corresponding input node. In a complementary manner, when a differential signal is applied across the input nodes, one current switch is open, while the other current switch is closed, and vice versa. A current allocation component allocates current between the two input current switches such that, when the first current switch is closed and the second current switch is open, increasing current is allocated through the first current switch and the intervening current path between the current allocation component and the first current switch, and vice versa. The circuit includes complementary pre-emphasis and/or current-aided pre-emphasis mechanisms that boost differential output transmission edges.

Abstract: A differential signal output driver circuit having four switching transistors and having a bias transistor that shields each of the switching transistors from the corresponding output terminal thereby blocking the Miller capacitance of the switching capacitor from generating overshoot or undershoot in the output differential voltage. Also, the output driver circuit may be driven by a differential skew cancellation circuit that generates a balanced differential signal to drive the switching transistors to further improve signal integrity. The signal path for generating each signal in the differential signal goes through a similar structure thereby ensuring similar slew in each differential signal provided to the output driver circuit.

Abstract: A digitally controlled impedance driver circuit including a number of fingers, some of which having FETs and series resistors sized in binary or other differential ratios, and some of the higher power FETs being sized in equal ratio and perhaps sharing a series resistor. A DCI controller circuit periodically determines a configuration of the DCI driver circuit that would result in the DCI driver circuit approximating a target impedance. Each time the DCI controller circuit does this, a comparator determines if the impedance of the DCI driver circuit should be increased or decreased. A noise attenuation circuit turns off (or on) only one of the high power fingers if the controller circuit determines that more (or less) impedance is needed even if turning off (or on) only one of the fingers would not result in the configuration of the DCI driver circuit determined by the controller circuit.

Abstract: A complementary differential amplifier includes two differential amplifiers. Each differential amplifier includes two input FETs (or bipolar transistors) having gate terminals coupled to the input terminals of the complementary differential amplifier. Two current load p-type field-effect transistors are each coupled in series between one voltage source and a drain terminal of a respective input FET. A current source FET is coupled in series between a common source terminal of the two input n-type field-effect transistors and a low voltage source. Only two FETs are needed to bias all of the current load and source FETs. A complementary folded cascode stage as well as an inverter stage may also be included.