Patents by Inventor Zhongmin Xu

Zhongmin Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS OF 1,2,5-TRI-O-BENZOYL-3-DIBENZYLAMINO-3-DEOXYRIBOSE AS INTERMEDIATE FOR PRODUCING 3'-AMINO-3'-DEOXYADENOSINE AND 3'-AMINO-3'-DEOXYGUANOSINE AND THE PROTECTED DERIVATIVES THEREOF
    Publication number: 20230357306
    Abstract: The invention generally relates to improved processes for the preparation of intermediates of a cyclic dinucleotide which is useful as a STING agonist.
    Type: Application
    Filed: February 5, 2020
    Publication date: November 9, 2023
    Inventors: Changxia Yuan, Michael Anthony Schmidt, Adrian Ortiz, Amanda J. Rogers, Jason J. Zhu, Zhongmin Xu, Miao Yu, Eric M. Simmons, Shulin Wu
  • Methods of producing an HIV maturation inhibitor
    Patent number: 10221208
    Abstract: A method for producing HIV maturation inhibitor compound is set forth using betulin as starting material, and utilizing Lossen rearrangement techniques.
    Type: Grant
    Filed: April 14, 2016
    Date of Patent: March 5, 2019
    Assignee: VIIV HEALTHCARE UK (NO.4) LIMITED
    Inventors: Adrian Ortiz, Maxime Soumeillant, Scott A. Savage, Neil A. Strotman, Martin D. Eastgate, Matthew W. Haley, Jeanne Ho, Jeffrey A. Nye, Zhongmin Xu, Susanne Kiau, Tamas Benkovics, Yichen Tan
  • METHODS OF PRODUCING AN HIV MATURATION INHIBITOR
    Publication number: 20180072691
    Abstract: A method for producing HIV maturation inhibitor compound is set forth using betulin as starting material, and utilizing Lossen rearrangement techniques.
    Type: Application
    Filed: April 14, 2016
    Publication date: March 15, 2018
    Inventors: Adrian ORTIZ, Maxime SOUMEILLANT, Scott A. SAVAGE, Neil A. STROTMAN, Martin D. EASTGATE, Matthew W. HALEY, Jeanne HO, Jeffrey A. NYE, Zhongmin XU, Susanne KIAU, Tamas BENKOVICS, Yichen TAN
  • Process for the preparation of [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2, 1-F][1,2,4]triazin-6-yloxy]-1-methylethyl ester
    Patent number: 7671199
    Abstract: The invention relates to an improved process for preparing [(1R), 2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Grant
    Filed: April 20, 2007
    Date of Patent: March 2, 2010
    Assignee: Britsol-Myers Squibb Company
    Inventors: Gerard A. Crispino, Mourad Hamedi, Thomas L. LaPorte, John E. Thornton, Jaan A. Pesti, Zhongmin Xu, Paul C. Lobben, David K. Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Ann Spangler, Robert P. Discordia, Francis S. Gibson
  • PROCESS FOR THE PREPARATION OF [(1R), 2S]-2-AMINOPROPIONIC ACID 2-[4-(4-FLUORO-2-METHYL-1H-INDOL-5-YLOXY)-5-METHYLPYRROLO[2,1-f][1,2,4]TRIAZIN-6-YLOXY]-1-METHYLETHYL ESTER
    Publication number: 20070249610
    Abstract: The invention relates to an improved process for preparing [(1R),2S]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1H-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester of the formula: Compound I has been shown to be useful for the treatment of certain types of cancer.
    Type: Application
    Filed: April 20, 2007
    Publication date: October 25, 2007
    Inventors: Gerard Crispino, Mourad Hamedi, Thomas LaPorte, John Thornton, Jaan Pesti, Zhongmin Xu, Paul Lobben, David Leahy, Jale Muslehiddinoglu, Chiajen Lai, Lori Spangler, Robert Discordia
  • Process for the preparation of tetrazol-derived compounds as growth hormone secretagogues
    Publication number: 20050096466
    Abstract: A process for the preparation of tetrazole-derived compounds useful as growth hormone secretagogues is described.
    Type: Application
    Filed: September 20, 2004
    Publication date: May 5, 2005
    Inventors: Mark Schwinden, Zhongmin Xu, Jollie Godfrey
  • Beta lactam compounds and their use as inhibitors of tryptase
    Patent number: 6335324
    Abstract: Compounds of the formulas: are disclosed. These compounds inhibit tryptase as well as other enzyme systems or are selective tryptase inhibitors and are useful as antiinflammatory agents particularly in the treatment of chronic asthma.
    Type: Grant
    Filed: December 13, 1999
    Date of Patent: January 1, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Gregory S. Bisacchi, William A. Slusarchyk, Uwe Treuner, James C. Sutton, Robert Zahler, Steven Seiler, David R. Kronenthal, Michael E. Randazzo, Mark D. Schwinden, Zhongmin Xu, Zhongping Shi