Patents by Inventor Zhongping YAO
Zhongping YAO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230326558Abstract: Peptide sequencing is important in decoding data stored in a data-encoded peptide. Tandem mass spectrometry (MS/MS) is particularly useful for peptide sequencing. In a computer-implemented method for sequencing the data-encoded peptide from an experimental spectrum, raw data of the experimental spectrum are first preprocessed to remove uninterpretable peaks to yield preprocessed data. A first set of one or more candidate sequences contending for a peptide sequence of the peptide is identified from a spectrum graph. The spectrum graph is formed according to the preprocessed data rather than the raw data for generating a fewer number of candidate sequences to thereby reduce a time cost in sequencing. The first candidate-sequence set is then processed to estimate the peptide sequence to thereby obtain a set of peptide-sequence estimate(s). Each estimate is verified whether it is invalid. The set of peptide-sequence estimate(s) is purged to remove any invalid estimate.Type: ApplicationFiled: April 10, 2023Publication date: October 12, 2023Inventors: Zhongping YAO, Cheuk Chi NG, Francis Chung Ming LAU, Wai Man TAM
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Patent number: 11315023Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.Type: GrantFiled: December 19, 2018Date of Patent: April 26, 2022Assignee: THE HONG KONG POLYTECHNIC UNIVERSITYInventors: Zhongping Yao, Cheuk Chi Albert Ng, Chung Ming Lau, Wai Man Tam
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Patent number: 11302421Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.Type: GrantFiled: October 12, 2020Date of Patent: April 12, 2022Assignee: THE HONG KONG POLYTECHNIC UNIVERSITYInventors: Zhongping Yao, Cheuk Chi Albert Ng, Haidi Yin
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Publication number: 20210090688Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.Type: ApplicationFiled: October 12, 2020Publication date: March 25, 2021Inventors: Zhongping YAO, Cheuk Chi Albert NG, Haidi YIN
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Publication number: 20210088495Abstract: The present disclosure provides a method and system for analysing one or more edible oil samples. In an embodiment the disclosure provides for calibrating the matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) data obtained for one or more edible oil samples to obtain calibrated spectral data; and comparing the calibrated spectral data derived from the one or more samples against a library of calibrated MALDI-MS spectra for a plurality of edible oil samples to determine the most likely composition of the one or more edible oil samples.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Applicant: The Hong Kong Polytechnic UniversityInventors: Zhongping YAO, Cheuk Chi Albert NG, Tsz-tsun NG, Suying LI
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Patent number: 10859552Abstract: The present disclosure provides a method and system for analysing one or more edible oil samples. In an embodiment the disclosure provides for calibrating the matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) data obtained for one or more edible oil samples to obtain calibrated spectral data; and comparing the calibrated spectral data derived from the one or more samples against a library of calibrated MALDI-MS spectra for a plurality of edible oil samples to determine the most likely composition of the one or more edible oil samples.Type: GrantFiled: June 20, 2017Date of Patent: December 8, 2020Assignee: THE HONG KONG POLYTECHNIC UNIVERSITYInventors: Zhongping Yao, Cheuk Chi Albert Ng, Tsz-tsun Ng, Suying Li
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Publication number: 20190318247Abstract: Methods and systems for storing digital data into peptide sequences and retrieving digital data from peptide sequences are disclosed. The method for storing digital data into peptide sequences may include: encoding the digital data into a digital code; translating the digital code into the peptide sequences; and synthesizing the translated peptide sequences. The method for retrieving digital data from peptide sequences may include: sequencing and determining an order of the peptide sequences; converting the peptide sequences with the determined order into a digital code; and decoding the digital data from the digital code. Codes with error-correction capability are developed for encoding digital data into peptide sequences, and a computational method implemented in a software is developed for sequencing the digital data bearing peptides.Type: ApplicationFiled: December 19, 2018Publication date: October 17, 2019Inventors: Zhongping YAO, Cheuk Chi Albert NG, Chung Ming LAU, Wai Man TAM
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Publication number: 20180364210Abstract: The present disclosure provides a method and system for analysing one or more edible oil samples. In an embodiment the disclosure provides for calibrating the matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) data obtained for one or more edible oil samples to obtain calibrated spectral data; and comparing the calibrated spectral data derived from the one or more samples against a library of calibrated MALDI-MS spectra for a plurality of edible oil samples to determine the most likely composition of the one or more edible oil samples.Type: ApplicationFiled: June 20, 2017Publication date: December 20, 2018Applicant: The Hong Kong Polytechnic UniversityInventors: Zhongping YAO, Cheuk Chi Albert NG, Tsz-tsun NG, Suying LI