Abstract: A magnetically driven hopping soft robot based on magnetically programmed temperature-sensitive hydrogels includes first moving bodies and a second moving body. Several first moving bodies are distributed evenly on a bottom portion of the second moving body. The first moving bodies are made of a temperature-responsive hydrogel containing magnetic particles. An alternating magnetic field is applied to the first moving bodies to cause the first moving bodies to deform due to magnetocaloric effect. The first moving bodies have a two-layered structure. A first layer is made of a double-network cross-linked hydrogel and a second layer is made of a magnetic temperature-responsive hydrogel with added magnetic nanoparticles. An alternating magnetic field is applied to the first moving bodies in a manner that an amount of deformation of the second layer is greater than that of the first layer. The second layer is made of a temperature-responsive hydrogel with added magnetic nanoparticles.

Abstract: Methods are disclosed for treating a subject with a disorder, such as, but not limited to, a) fibrosis of an organ or tissue; b) solid organ transplant rejection; or c) a cardiac disease that is not myocardial infarction or myocardial ischemia. These methods include selecting a subject having or at risk of having the disorder, and administering to the subject a therapeutically effective amount of isolated nanovesicles derived from an extracellular matrix, wherein the nanovesicles contain interleukin (IL)-33 and comprise lysyl oxidase, and wherein the nanovesicles a) do not express CD63 or CD81, or b) are CD63lo CD81lo. In additional embodiments, methods are disclosed for increasing myoblast differentiation.

Abstract: A magnetically driven hopping soft robot based on magnetically programmed temperature-sensitive hydrogels includes first moving bodies and a second moving body. Several first moving bodies are distributed evenly on a bottom portion of the second moving body. The first moving bodies are made of a temperature-responsive hydrogel containing magnetic particles. An alternating magnetic field is applied to the first moving bodies to cause the first moving bodies to deform due to magnetocaloric effect. The first moving bodies have a two-layered structure. A first layer is made of a double-network cross-linked hydrogel and a second layer is made of a magnetic temperature-responsive hydrogel with added magnetic nanoparitcles. An alternating magnetic field is applied to the first moving bodies in a manner that an amount of deformation of the second layer is greater than that of the first layer. The second layer is made of a temperature-responsive hydrogel with added magnetic nanoparticles.