Abstract: Provided are compounds of Formula (I), methods of using the compounds as SHP2 inhibitors, and pharmaceutical compositions comprising such compounds. The compounds are useful in treating SHP2-mediated diseases.

Abstract: Disclosed is a compound as a fibroblast growth factor receptor 4 (FGFR4) inhibitor (as shown in formula (I)), and a pharmaceutical composition thereof and a preparation method therefor, as well as the use of same in the treatment of FGFR4-mediated diseases. The above-mentioned compounds act by participating in a number of processes, such as regulating cell proliferation, apoptosis, migration, neovascularization.

Abstract: A device for reducing pressure fluctuation of a pressure filter frame and a pressure filter. The device includes a pressure filter frame that is a cylindrical housing. An inner wall of the pressure filter frame is further provided with a buffer plate. A plurality of openings are provided in the buffer plate. A gap is remained between the buffer plate and the inner wall of the pressure filter frame. A plurality of supporting posts are disposed in the gap, which fixedly connect the inner wall of the pressure filter frame with the buffer plate.

Abstract: The present invention relates to a method for processing acetic acid solvent in Crude Terephthalic Acid (CTA) in an oxidized unit of a pure terephthalic acid (PTA) industrial apparatus. In the present invention, a filter cake in CTA is washed by means of a two-stage-three-step method. The present invention further shortens the production process of solvent exchanging technique of CTA pressure filters, improves production capacity of a device, reduces investment of the device, reduces energy consumption of a system, and solves the shortcomings of the existing CTA solvent exchanging technique of the pressure filters.

Abstract: A device for reducing pressure fluctuation of a pressure filter frame and a pressure filter. The device includes a pressure filter frame that is a cylindrical housing. An inner wall of the pressure filter frame is further provided with a buffer plate. A plurality of openings are provided in the buffer plate. A gap is remained between the buffer plate and the inner wall of the pressure filter frame. A plurality of supporting posts are disposed in the gap, which fixedly connect the inner wall of the pressure filter frame with the buffer plate.

Abstract: The present invention relates to a method for processing acetic acid solvent in Crude Terephthalic Acid (CTA) in an oxidized unit of a pure terephthalic acid (PTA) industrial apparatus. In the present invention, a filter cake in CTA is washed by means of a two-stage-three-step method. The present invention further shortens the production process of solvent exchanging technique of CTA pressure filters, improves production capacity of a device, reduces investment of the device, reduces energy consumption of a system, and solves the shortcomings of the existing CTA solvent exchanging technique of the pressure filters.

Abstract: A solvent exchanger and a method is provided for: pressurizing a CTA slurry into a solvent exchanger for separation and obtaining a mother liquor, a bias flow mother liquor and a suspended matter A; washing the suspended matter A to obtain a primary filtrate, a bias flow primary filtrate and a suspended matter B; washing the suspended matter B to obtain a secondary filtrate, a bias flow secondary filtrate and a suspended matter C; washing the suspended matter C to obtain a tertiary filtrate, a bias flow tertiary filtrate and a suspended matter D; washing the suspended matter D to obtain a fourth filtrate, a bias flow fourth filtrate and a suspended matter E; washing the suspended matter E to obtain a fifth filtrate, a bias flow fifth filtrate and a filter cake; and after finished, back-flushing the filter cake and then pulping to obtain a slurry, and discharging.

Abstract: The present invention relates to a method for processing acetic acid solvent in an oxidizing unit of a PTA industrial apparatus; said method uses a pressure filter machine to filter crude terephthalic acid slurry, and then, using a multi-stage counter-current method, uses washing water to wash the acetic acid solvent, and, by means of setting up a bias-current and drainage, prevents residual liquid in the filtrate pipe from entering the next area following the rotation of the pressure filter machine, improving washing efficiency and reducing the amount of washing water; the present invention integrates the processes of filtering and washing crude terephthalic acid into a single pressure filter machine, such that the process is shorter, the occupied floor space is reduced, and energy consumption is lower. A method feeding nitrogen gas into the mother liquor tank and washing liquid tank is used to regulate the pressure balance of the system.

Abstract: A solvent exchanger and a method is provided for: pressurizing a CTA slurry into a solvent exchanger for separation and obtaining a mother liquor, a bias flow mother liquor and a suspended matter A; washing the suspended matter A to obtain a primary filtrate, a bias flow primary filtrate and a suspended matter B; washing the suspended matter B to obtain a secondary filtrate, a bias flow secondary filtrate and a suspended matter C; washing the suspended matter C to obtain a tertiary filtrate, a bias flow tertiary filtrate and a suspended matter D; washing the suspended matter D to obtain a fourth filtrate, a bias flow fourth filtrate and a suspended matter E; washing the suspended matter E to obtain a fifth filtrate, a bias flow fifth filtrate and a filter cake; and after finished, back-flushing the filter cake and then pulping to obtain a slurry, and discharging.

Abstract: The present invention relates to a method for processing acetic acid solvent in an oxidising unit of a PTA industrial apparatus; said method uses a pressure filter machine to filter crude terephthalic acid slurry, and then, using a multi-stage counter-current method, uses washing water to wash the acetic acid solvent, and, by means of setting up a bias-current and drainage, prevents residual liquid in the filtrate pipe from entering the next area following the rotation of the pressure filter machine, improving washing efficiency and reducing the amount of washing water; the present invention integrates the processes of filtering and washing crude terephthalic acid into a single pressure filter machine, such that the process is shorter, the occupied floor space is reduced, and energy consumption is lower. A method feeding nitrogen gas into the mother liquor tank and washing liquid tank is used to regulate the pressure balance of the system.