Abstract: This invention relates to a closed-loop adaptive AC stimulation neural network control method and system, involving the technical field of AC stimulation neural regulation. This system is composed of an individualized navigation module, AC stimulation module, EEG acquisition module and adaptive coupling module. After the magnetic resonance image and functional magnetic resonance image of the regulation object are input into the individualized navigation module, the functional connectivity network is generated to finalize regulatory targets. The position of stimulating electrodes and the magnitude of the stimulating current are determined according to the target to be regulated. The stimulating frequency is determined according to the EEG of the regulation object and then input into the AC stimulation module for regulation.