Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: An automatic righting system includes a discrimination calibration module, a righting module, and a controller. The discrimination calibration module includes a distance sensing unit. The distance sensing unit is located at the front end of the glasses and configured to acquire the distance between the distance sensing unit and a first feature position. The righting module includes a push-up air cushion. The push-up air cushion is mounted at the front end of the glasses. The push-up air cushion is configured to be inflated to push the glasses to move upward. The controller is electrically connected to the distance sensing unit and the push-up air cushion. The controller is configured to control the push-up air cushion to start or stop to right the glasses according to a distance signal of the distance sensing unit.

Abstract: An apparatus, a system and a method for tuning a robot path for processing a workpiece. The method includes overlapping a visual representation of the robot path on a visual presentation of the workpiece. The visual presentation of the robot path includes at least one virtual point that corresponds to at least one controlling point in the robot path. The method further includes in response to receiving a user input for moving a virtual point in the at least one virtual point relative to the visual presentation of the workpiece, detecting an updated position of the virtual point caused by the user input; and tuning the robot path based on the updated position of the virtual point.

Abstract: Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.

Abstract: Ionizable cationic lipid compounds have an amine moiety from amino alcohols and a lipid moiety from a lipid synthesized via esterification. The ionizable cationic lipid compounds which comprise an amino alcohol mediated ionizable cationic lipid compound are useful for in vivo or in vitro delivery of one or more nucleic acid agents including DNA, siRNA, a microRNA, an mRNA, a RNAi, and a plasmid.

Abstract: Provided are a rotor shaft assembly, a rotor, and a motor. The rotor shaft assembly includes a magnetic core, a first end shaft, a second end shaft, and a protective sleeve. The protective sleeve is provided, in sequence, with a first through hole, a second through hole, and a third through hole; the first end shaft is disposed through the first through hole, at least part of the magnetic core is arranged inside the second through hole, and the second end shaft is disposed through the third through hole.

Abstract: A microscope, including an x motor, a y motor, and a z axis focusing driving mechanism that drive a stage to move; at least one knob operatively coupled to the x motor or y motor or the z axis focusing driving mechanism selectively via a controller; and at least one button coupled to the controller in communication. The controller is configured to disconnect a normal operative coupling between the knob and the z axis focusing driving mechanism and establish an operative coupling between the knob and the x motor or y motor when receiving a predetermined button signal, and restore the normal operative coupling between the knob and the z axis focusing driving mechanism and disconnect the operative coupling between the knob and the x motor or y motor when no longer receiving the predetermined button signal or when receiving a next button signal.

Abstract: One aspect of the disclosure describes a lipid conjugated cationic molecule. Other aspects of the disclosure describes nanoparticle delivery systems and methods of making the systems are disclosed. An embodiment of the nanoparticle delivery system has sustained gene delivery properties, the nanoparticle delivery system can be synthesized using biodegradable and biocompatible polymers via self-assembly. The nanoparticle delivery system comprises a plurality of nanoparticle depots, each of which has a particle-in-particle structure, and is composed of a polymeric nanoparticle, which encapsulates cationic molecule/nucleic acid complexes, facilitating enhanced retention and prolonged release of the gene payload. The polymeric nanoparticle comprises a shell, and a nanocomplex of the cationic molecule and a polynucleotide, the nanocomplexes are distributed within the shell and/or embedded in the shell. Another embodiment of the nanoparticle delivery system has one or more nanocomplexes.

Abstract: The present disclosure discloses a method of manufacturing silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen, which relates to organic/inorganic hybrid nanoparticles, dispersing SiO2 in an organic solvent, then adding THPS, stirring, and finally adding p-phenylenediamine, reacting, centrifuging, washing, and drying to obtain silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen. The silicon dioxide nanoparticles modified by the polymer containing phosphorus and nitrogen have effects in flame retardancy, strengthening effect of polymer matrixes, and are expected to be widely used in the halogen-free synergistic flame retardancy of polymer materials.

Abstract: Provided are a rotor shaft assembly, a rotor, and a motor. The rotor shaft assembly includes a magnetic core, a first end shaft, a second end shaft, and a protective sleeve. The protective sleeve is provided, in sequence, with a first through hole, a second through hole, and a third through hole; the first end shaft is disposed through the first through hole, at least part of the magnetic core is arranged inside the second through hole, and the second end shaft is disposed through the third through hole.

Abstract: The invention relates to a microscope, comprising a stage (13); an x motor, a y motor, and a z axis focusing driving mechanism that drive the stage to move along left-right, front-rear, and up-down directions respectively; a controller; at least one knob (3) which is operatively coupled to the x motor and/or y motor or the z axis focusing driving mechanism selectively by means of the controller to control operation of the coupled motor or the coupled z axis focusing driving mechanism; and at least one button (4, 5) which is coupled to the controller in communication and sends to the controller a button signal indicating that the button has been triggered by operation of the microscope user.

Abstract: The present disclosure discloses a method of manufacturing silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen, which relates to organic/inorganic hybrid nanoparticles, dispersing SiO2 in an organic solvent, then adding THPS, stirring, and finally adding p-phenylenediamine, reacting, centrifuging, washing, and drying to obtain silicon dioxide nanoparticles modified by a polymer containing phosphorus and nitrogen. The silicon dioxide nanoparticles modified by the polymer containing phosphorus and nitrogen have effects in flame retardancy, strengthening effect of polymer matrixes, and are expected to be widely used in the halogen-free synergistic flame retardancy of polymer materials.

Abstract: A calibration plate for measuring calibration of digital microscope and methods of using the same. The calibration plate comprises at least one calibration area formed with a surface structure which includes a plurality of grid cells arranged periodically, wherein at least part of boundary and/or at least part of apexes of each grid cell can be identified by an optical imaging system of the digital microscope. The invention also includes a digital microscope system equipped with the calibration plate.

Abstract: A calibration plate for measuring calibration of digital microscope and methods of using the same. The calibration plate comprises at least one calibration area formed with a surface structure which includes a plurality of grid cells arranged periodically, wherein at least part of boundary and/or at least part of apexes of each grid cell can be identified by an optical imaging system of the digital microscope. The invention also includes a digital microscope system equipped with the calibration plate.

Abstract: Disclosed herein are compounds, extracts, and active fractions of the plant Geum japonicum alone or in combination with Centella Asiatica and methods for preventing or treating heart failure. The compounds provided herein can be formulated into pharmaceutical compositions and medicaments that are useful in the disclosed methods. Also provided are the use of the compounds and extracts in preparing pharmaceutical formulations and medicaments.

Abstract: Disclosed herein are compounds, extracts, and active fractions of the plant Geum japonicum alone or in combination with Centella Asiatica and methods for preventing or treating heart failure. The compounds provided herein can be formulated into pharmaceutical compositions and medicaments that are useful in the disclosed methods. Also provided are the use of the compounds and extracts in preparing pharmaceutical formulations and medicaments.