Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: The present invention relates to an experimental apparatus for researching characteristics of subsea tunnel at bottom of seabed under wave, comprising main control system, wave making test system, rock and soil confining pressure test system and water level regulation test system, wherein a bottom of the rock and soil confining pressure test system is connected with the water level regulation test system; a bottom of the wave making test system is connected with the rock and soil confining pressure test system; and all test systems are electrically connected with the main control system. The experimental apparatus, when being small, may simulate the situation of the subsea tunnel under a nonlinear complex wave, may consider the common action of the seabed and the wave, and may regulate water levels and soil pressures, having perfect functions and effectively exploring the effect of various aspects on the subsea tunnel.

Abstract: The present invention relates to method for filling deformable karst cave, and the steps are: penetrating a grouting pipe into an elastic silicone tube, penetrating the grouting pipe and the elastic silicone tube into a deformable bracket, and lowering into a karst cave; sealing the elastic silicone tube, injecting silicate resin materials into the grouting pipe, and injecting steel fiber reinforced grout to implement a “block stone-like” structure; sealing the elastic silicone tube, separating the “block stone-like” structure from the elastic silicone tube to complete a “block stone-like” structure; lowering the elastic silicone tube and the deformable bracket, sealing the elastic silicone tube, lowering the elastic silicone tube and the deformable bracket tore construct the “block stone-like” structure, and completing the filling. The present invention may effectively stabilize the karst cave, ensure safe tunnel construction and stable surrounding rocks, and improve engineering construction speed.

Abstract: The present invention belongs to the technical field of ocean traffic engineering, and relates to a fabricated ocean tunnel structure with an escape device and an application method thereof. The present invention includes a fabricated ocean tunnel structure and an escape device. the partition plate separates a middle bin in the tunnel, and the escape device is connected into the middle bin; and the escape device includes a rescue capsule, transverse ladders are evenly arranged in the rescue capsule, and a balancing weight block and a rescue equipment area are arranged at the bottom of the rescue capsule. The ocean tunnel structure can be provided with a rescue device during installation, and the safety of personnel escape can be guaranteed; therefore, the safety of the ocean tunnel structure is improved, cost is relatively low, secondary damage to the ocean tunnel structure is not needed.

Abstract: A sintered R—Fe—B permanent magnet has at least a grain boundary and composite main phase grains. The grain boundary has an RH-rich phase distributed in the form of an agglomerate within the grain boundary between the composite main phase grains, preferably at the intersection of any adjacent three or more composite main phase grains. The RH-rich phase is continuously distributed along the grain boundary in the form of a thin-layer stripe. The composite main phase grain has a core-shell structure, which includes a core structure having an R-T-B type phase structure and a shell structure on the outer layer of the core structure. The core structure contains Ce-rich main phase grains and Ce-poor main phase grains.

Abstract: The present invention provides a method and a system for preparing pulp for paper with grass straws as raw material. The method of the present invention includes the following steps: 1) adding water in raw material for pulping, performing a first enzymolysis with ligninolytic enzyme; 2) cooking the first enzymolysis product at 80-130° C.; 3) performing second enzymolysis with hemicellulase to the cooked product. The method of the present invention is able to improve the pulp yield, reduce discharge of pollutants from black liquor, lower alkali consumption and energy consumption, and facilitate extraction of lignin and C-5 sugars, and pulp has a high quality.

Abstract: The present invention relates to the technical field of plugs and sockets for electrical appliances. Disclosed are a surface contact plug and socket, comprising a matching plug and socket; a plug contact piece connected with a plug electric wire is arranged on the lower surface of the plug; and a socket contact piece connected with a socket electric wire is arranged on the upper surface of the socket; when the plug is inserted into the socket, the plug contact piece vertically or obliquely meets the socket contact piece to cause surface contact electrification. The surface contact plug and socket of the present invention employ surface contact between contact pieces, enlarge the contact area and improve current transmission capacity since the plug and socket are of the same size, and therefore the contact is always reliable, and the more the plug and the socket are used, the more reliable the contact is.

Abstract: The present invention relates to the technical field of plugs and sockets for electrical appliances. Disclosed are a surface contact plug and socket, comprising a matching plug and socket; a plug contact piece connected with a plug electric wire is arranged on the lower surface of the plug; and a socket contact piece connected with a socket electric wire is arranged on the upper surface of the socket; when the plug is inserted into the socket, the plug contact piece vertically or obliquely meets the socket contact piece to cause surface contact electrification. The surface contact plug and socket of the present invention employ surface contact between contact pieces, enlarge the contact area and improve current transmission capacity since the plug and socket are of the same size, and therefore the contact is always reliable, and the more the plug and the socket are used, the more reliable the contact is.