Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: The present invention relates to an experimental apparatus for researching characteristics of subsea tunnel at bottom of seabed under wave, comprising main control system, wave making test system, rock and soil confining pressure test system and water level regulation test system, wherein a bottom of the rock and soil confining pressure test system is connected with the water level regulation test system; a bottom of the wave making test system is connected with the rock and soil confining pressure test system; and all test systems are electrically connected with the main control system. The experimental apparatus, when being small, may simulate the situation of the subsea tunnel under a nonlinear complex wave, may consider the common action of the seabed and the wave, and may regulate water levels and soil pressures, having perfect functions and effectively exploring the effect of various aspects on the subsea tunnel.

Abstract: An automatic righting system includes a discrimination calibration module, a righting module, and a controller. The discrimination calibration module includes a distance sensing unit. The distance sensing unit is located at the front end of the glasses and configured to acquire the distance between the distance sensing unit and a first feature position. The righting module includes a push-up air cushion. The push-up air cushion is mounted at the front end of the glasses. The push-up air cushion is configured to be inflated to push the glasses to move upward. The controller is electrically connected to the distance sensing unit and the push-up air cushion. The controller is configured to control the push-up air cushion to start or stop to right the glasses according to a distance signal of the distance sensing unit.

Abstract: The present invention relates to method for filling deformable karst cave, and the steps are: penetrating a grouting pipe into an elastic silicone tube, penetrating the grouting pipe and the elastic silicone tube into a deformable bracket, and lowering into a karst cave; sealing the elastic silicone tube, injecting silicate resin materials into the grouting pipe, and injecting steel fiber reinforced grout to implement a “block stone-like” structure; sealing the elastic silicone tube, separating the “block stone-like” structure from the elastic silicone tube to complete a “block stone-like” structure; lowering the elastic silicone tube and the deformable bracket, sealing the elastic silicone tube, lowering the elastic silicone tube and the deformable bracket tore construct the “block stone-like” structure, and completing the filling. The present invention may effectively stabilize the karst cave, ensure safe tunnel construction and stable surrounding rocks, and improve engineering construction speed.

Abstract: The present invention belongs to the technical field of ocean traffic engineering, and relates to a fabricated ocean tunnel structure with an escape device and an application method thereof. The present invention includes a fabricated ocean tunnel structure and an escape device. the partition plate separates a middle bin in the tunnel, and the escape device is connected into the middle bin; and the escape device includes a rescue capsule, transverse ladders are evenly arranged in the rescue capsule, and a balancing weight block and a rescue equipment area are arranged at the bottom of the rescue capsule. The ocean tunnel structure can be provided with a rescue device during installation, and the safety of personnel escape can be guaranteed; therefore, the safety of the ocean tunnel structure is improved, cost is relatively low, secondary damage to the ocean tunnel structure is not needed.

Abstract: Fast simultaneous feasibility testing (SFT) for management of an electrical power grid is achieved through various innovations. The computation problem relates to evaluation of candidate solutions for external power flows into a power grid, with respect to predetermined constraints and contingencies. A perturbation approach with precomputation is extended to encompass grid states (e.g. time periods) in addition to contingencies. Advantages derive from: fewer factorizations or inversions of large matrices; decoupling of state-dependent and contingency-dependent perturbations, leaving relatively few perturbations jointly dependent on both state and contingency; or making approximations by discarding small jointly dependent terms. Significant computation reductions allow a single workstation to perform SFT for 36 hours of a day-ahead cycle.

Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.

Abstract: A mine exploitation method based on stoping, separation and filling control is disclosed herein. The method includes deploying a gangue-less coal mining system; choosing a suitable coal and gangue separation method according to a separation requirement; choosing a suitable filling method according to mine geology, production conditions and rock stratum control requirement; reversely calculating a filling rate according to gangue discharge requirement and control indexes by utilizing theoretical calculation, simulation and experiment; determining a filling process and a separation process according to the filling rate; and feeding back and adjusting the filling process and separation process parameters by monitoring filling and control effect indexes.

Abstract: A degradable intestinal complete diversion device, made of biocompatible degradable materials, includes a circular tube constituting the bridge for the intestinal incisions on both sides to crawl towards each other and anastomosed; the end of the circular tube is connected with a gradually expanding flared opening, and a convex ring for binding the broken end of the intestine is arranged on the circular tube near each flared opening, and the hollow inner cavity of the circular tube is provided with a barrier film for blocking the hollow inner cavity. The invention used with a drainage tube realizes complete intestinal diversion without secondary operations of stoma reintroduction.