Patents by Inventor Zhongyu Xie

Zhongyu Xie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted pyridazinone compound and use thereof
    Patent number: 11964962
    Abstract: Disclosed is a pyridazinone compound represented by Formula (I), or a pharmaceutically acceptable salt, prodrug, hydrate, solvate, polymorph, stereoisomer, or isotopic variant thereof. The compound can be used for preparation of medicinal products for treatment and/or prophylaxis of a disease or condition associated with thyroid hormone abnormalities. The compound has higher selectivity to TH?, better pharmacokinetic parameters, desired stability, and higher agonistic activity toward TH?.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: April 23, 2024
    Assignee: SHANDONG FIRST MEDICAL UNIVERSITY & SHANDONG ACADEMY OF MEDICAL SCIENCES
    Inventors: Qingqiang Yao, Weilin Xie, Véronique Plantevin Krenitsky, Bo Liu, Yan Li, Ying Zhi, Ying Li, Yanling Mu, Jingyong Sun, Haiyang Wang, Zhongyu Wu, Haijiao Chen, Tiandi Ding, Yue Wang, Haoyi Sun, Feipeng Zhang, Peng Meng, Qingxu Liu, Huajie Li, Yige Wang, Shanshan Wen
  • Reagents and methods for detecting protein lysine 3-hydroxybutyrylation
    Patent number: 11385240
    Abstract: The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.
    Type: Grant
    Filed: June 27, 2019
    Date of Patent: July 12, 2022
    Assignee: PTM BIO LLC
    Inventors: Yingming Zhao, Zhongyu Xie
  • REAGENTS AND METHODS FOR DETECTING PROTEIN LYSINE 3-HYDROXYBUTYRYLATION
    Publication number: 20190331695
    Abstract: The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.
    Type: Application
    Filed: June 27, 2019
    Publication date: October 31, 2019
    Applicant: PTM BIO LLC
    Inventors: Yingming ZHAO, Zhongyu XIE
  • Reagents And Methods for Detecting Protein Lysine 3-Hydroxybutyrylation
    Publication number: 20150051093
    Abstract: The invention provides an isolated peptide comprising a lysine 3-hydroxybutyrylation site, a lysine 3-hydroxybutyrylation specific affinity reagent that specifically binds to the peptide, and a method for detecting protein lysine 3-hydroxybutyrylation in a sample using the reagent.
    Type: Application
    Filed: August 18, 2014
    Publication date: February 19, 2015
    Applicant: PTM Biolabs, Inc.
    Inventors: Yingming Zhao, Zhongyu Xie