Patents by Inventor Zhongyuan Zhu

Zhongyuan Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12138316
    Abstract: The present invention provides an antibody-drug conjugate specifically binding to B7H3 and a pharmaceutical composition comprising the same. A method for using the antibody-drug conjugate of the present invention and use thereof are also provided herein.
    Type: Grant
    Filed: November 16, 2023
    Date of Patent: November 12, 2024
    Assignee: Duality Biologics (Suzhou) Co., Ltd.
    Inventors: Zhongyuan Zhu, Chen Zhong, Yu Zhang, Chenggang Li
  • Publication number: 20240350545
    Abstract: The present application provides modified immune cells that express TLR receptors. In some embodiments, the modified immune cell further comprises an engineered receptor such as a chimeric antigen receptor (CAR). The present application also provides methods and pharmaceutical compositions for cancer treatment using the modified immune cells described herein.
    Type: Application
    Filed: August 18, 2022
    Publication date: October 24, 2024
    Inventors: Yanliang ZHU, Qingling JIANG, Zhongyuan TU, Yafeng ZHANG, Shu WU, Xiaohu FAN
  • Publication number: 20240320117
    Abstract: A computing device may receive trigger data defining a trigger event and logic to add an enriched event associated with the trigger event. A computing device may detect occurrence of the trigger event in execution of one or more digital services by an executable service platform in an online operational environment of a service provider system based on the trigger data. A computing device may generate event data describing the execution of the trigger event and the enriched event responsive to the detecting based on the logic of the trigger data. A computing device may store the event data within an offline simulation environment. A computing device may simulate operation of the executable service platform offline using the event data. A computing device may output a result of the simulating for display in a user interface.
    Type: Application
    Filed: March 22, 2023
    Publication date: September 26, 2024
    Applicant: eBay Inc.
    Inventors: Jianzhong Chen, Tianyu Chen, Zhengfei Chen, Xin Li, Yiheng Wang, Zhongyuan Wu, Yucai Yu, Guansheng Zhu
  • Patent number: 12091418
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: October 26, 2023
    Date of Patent: September 17, 2024
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20240174686
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: November 10, 2023
    Publication date: May 30, 2024
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Publication number: 20240148892
    Abstract: The present invention provides an antibody-drug conjugate specifically binding to B7H3 and a pharmaceutical composition comprising the same. A method for using the antibody-drug conjugate of the present invention and use thereof are also provided herein.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 9, 2024
    Applicant: Duality Biologics (Suzhou) Co., Ltd.
    Inventors: Zhongyuan ZHU, Chen ZHONG, Yu ZHANG, Chenggang LI
  • Publication number: 20240132516
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: October 26, 2023
    Publication date: April 25, 2024
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11952384
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: April 9, 2024
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230331738
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: March 22, 2023
    Publication date: October 19, 2023
    Inventors: Yu ZHANG, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230212182
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: December 28, 2022
    Publication date: July 6, 2023
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11685742
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 27, 2023
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230086097
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: May 26, 2022
    Publication date: March 23, 2023
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11607459
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: March 21, 2023
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Patent number: 10610523
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: April 7, 2020
    Assignee: BTCP PHARMA, LLC
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Patent number: 10135923
    Abstract: A data transfer method is provided for a terminal coupled to a server by one or more networks. The method includes detecting a connection type of a current network between the terminal and the server and performing data transfer between the terminal and the server when it is detected that the connection type of the current network is a wireless fidelity (WiFi) connection. Further, the method includes suspending data transfer between the terminal and the server when it is detected that the connection type of the current network is a non-WiFi connection.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: November 20, 2018
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventor: Zhongyuan Zhu
  • Publication number: 20180303813
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Patent number: 10016403
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 10, 2018
    Assignee: INSYS DEVELOPMENT COMPANY, INC.
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Publication number: 20180160709
    Abstract: The current invention relates to a gargle dosage formulation and a method for removing the bitter taste in oral medication or food. Particularly, this bitter-removal formulation comprises at least one of two preparations, the first preparation and the second preparation. The current invention also discloses a method of using the preparations before and after taking oral medication or food. Right before taking oral medication or food, the first preparation is used to gargle the user's oral cavity. After it is spat out, the first preparation forms a thin layer on the surface of the oral mucosa to cover, shield, and protect taste buds from the direct contact with oral medication or food. Immediately after oral medication or food is taken, the second preparation is used to gargle and clean the user's taste buds, which effectively elutes mucosa-binding bitter ingredients from the oral cavity.
    Type: Application
    Filed: December 8, 2017
    Publication date: June 14, 2018
    Inventors: Zhongyuan Zhu, Fanfeng Ma, Mu Zhu, Xiyuan Zhu
  • Publication number: 20170239230
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Application
    Filed: April 4, 2017
    Publication date: August 24, 2017
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Publication number: 20170202820
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Application
    Filed: April 4, 2017
    Publication date: July 20, 2017
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh