Patents by Inventor Zhongyuan Zhu

Zhongyuan Zhu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250059141
    Abstract: The present application relates to a TLR modulator and the use thereof. Specifically, the present application relates to a compound for modulating TLR activity, or a tautomer, a mesomer, a racemate, an enantiomer, a diastereoisomer, or a mixture form thereof, or a pharmaceutically acceptable salt thereof. The present application further relates to a method for preparing the compound of the present application and the use thereof.
    Type: Application
    Filed: December 16, 2022
    Publication date: February 20, 2025
    Inventors: Yu ZHANG, Bing LI, Xi LI, Haiqing HUA, Zhongyuan ZHU
  • Publication number: 20250032630
    Abstract: The present invention provides an anti-B7H4 antibody-drug conjugate specifically binding to B7H4, and a composition comprising same, wherein the structure of the anti-B7H4 antibody-drug conjugate is shown as formula (I-1). The present invention further provides a method and use of the antibody-drug conjugate provided herein. The anti-B7H4 antibody-drug conjugate of the present invention has better inhibitory activity against tumor cell proliferation in vitro and a better tumor inhibition effect in vivo.
    Type: Application
    Filed: September 27, 2024
    Publication date: January 30, 2025
    Applicant: Duality Biologics (Suzhou) Co., Ltd.
    Inventors: Zhongyuan ZHU, Chen ZHONG, Yu ZHANG, Yunhua ZHOU
  • Publication number: 20250002527
    Abstract: The present invention relates to a steroid compound and a conjugate thereof, and specifically relates to a compound and a conjugate thereof, or a tautomer, a mesomer, a racemate, an enantiomer and a diastereoisomer thereof, or a mixture form thereof, or a pharmaceutically acceptable salt thereof; and a method for preparing the compound and the conjugate thereof and the use thereof.
    Type: Application
    Filed: August 25, 2022
    Publication date: January 2, 2025
    Inventors: Yu ZHANG, Bing LI, Hongxia SHEN, Jian LI, Xi LI, Haiqing HUA, Zhongyuan ZHU
  • Patent number: 12168667
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: November 10, 2023
    Date of Patent: December 17, 2024
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Patent number: 12138316
    Abstract: The present invention provides an antibody-drug conjugate specifically binding to B7H3 and a pharmaceutical composition comprising the same. A method for using the antibody-drug conjugate of the present invention and use thereof are also provided herein.
    Type: Grant
    Filed: November 16, 2023
    Date of Patent: November 12, 2024
    Assignee: Duality Biologics (Suzhou) Co., Ltd.
    Inventors: Zhongyuan Zhu, Chen Zhong, Yu Zhang, Chenggang Li
  • Patent number: 12091418
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: October 26, 2023
    Date of Patent: September 17, 2024
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20240174686
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: November 10, 2023
    Publication date: May 30, 2024
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Publication number: 20240148892
    Abstract: The present invention provides an antibody-drug conjugate specifically binding to B7H3 and a pharmaceutical composition comprising the same. A method for using the antibody-drug conjugate of the present invention and use thereof are also provided herein.
    Type: Application
    Filed: November 16, 2023
    Publication date: May 9, 2024
    Applicant: Duality Biologics (Suzhou) Co., Ltd.
    Inventors: Zhongyuan ZHU, Chen ZHONG, Yu ZHANG, Chenggang LI
  • Publication number: 20240132516
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: October 26, 2023
    Publication date: April 25, 2024
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11952384
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: December 28, 2022
    Date of Patent: April 9, 2024
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230331738
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: March 22, 2023
    Publication date: October 19, 2023
    Inventors: Yu ZHANG, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230212182
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: December 28, 2022
    Publication date: July 6, 2023
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11685742
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: May 26, 2022
    Date of Patent: June 27, 2023
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Publication number: 20230086097
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Application
    Filed: May 26, 2022
    Publication date: March 23, 2023
    Inventors: Yu ZHANG, Zhongyuan ZHU, Haiqing HUA, Bing LI, Jian LI, Shengchao LIN, Xi LI, Hongxia SHEN
  • Patent number: 11607459
    Abstract: The present application relates to an anti-tumor compound and a preparation method and use thereof, and in particular to a compound or a tautomer, a mesomer, a racemate, an enantiomer or a diastereoisomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof, and a preparation method and use thereof.
    Type: Grant
    Filed: May 31, 2022
    Date of Patent: March 21, 2023
    Assignee: DUALITY BIOLOGICS (SUZHOU) CO., LTD.
    Inventors: Yu Zhang, Zhongyuan Zhu, Haiqing Hua, Bing Li, Jian Li, Shengchao Lin, Xi Li, Hongxia Shen
  • Patent number: 10610523
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable sale thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: April 7, 2020
    Assignee: BTCP PHARMA, LLC
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Patent number: 10135923
    Abstract: A data transfer method is provided for a terminal coupled to a server by one or more networks. The method includes detecting a connection type of a current network between the terminal and the server and performing data transfer between the terminal and the server when it is detected that the connection type of the current network is a wireless fidelity (WiFi) connection. Further, the method includes suspending data transfer between the terminal and the server when it is detected that the connection type of the current network is a non-WiFi connection.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: November 20, 2018
    Assignee: TENCENT TECHNOLOGY (SHENZHEN) COMPANY LIMITED
    Inventor: Zhongyuan Zhu
  • Publication number: 20180303813
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Application
    Filed: June 27, 2018
    Publication date: October 25, 2018
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Patent number: 10016403
    Abstract: The present invention is directed to sublingual formulations containing fentanyl, a pharmaceutically acceptable salt thereof, or derivative thereof, suitable for administration to a patient, and methods for treatment with the formulations.
    Type: Grant
    Filed: April 4, 2017
    Date of Patent: July 10, 2018
    Assignee: INSYS DEVELOPMENT COMPANY, INC.
    Inventors: S. George Kottayil, Venkat R. Goskonda, Zhongyuan Zhu, Linet Kattookaran, Neha Parikh
  • Publication number: 20180160709
    Abstract: The current invention relates to a gargle dosage formulation and a method for removing the bitter taste in oral medication or food. Particularly, this bitter-removal formulation comprises at least one of two preparations, the first preparation and the second preparation. The current invention also discloses a method of using the preparations before and after taking oral medication or food. Right before taking oral medication or food, the first preparation is used to gargle the user's oral cavity. After it is spat out, the first preparation forms a thin layer on the surface of the oral mucosa to cover, shield, and protect taste buds from the direct contact with oral medication or food. Immediately after oral medication or food is taken, the second preparation is used to gargle and clean the user's taste buds, which effectively elutes mucosa-binding bitter ingredients from the oral cavity.
    Type: Application
    Filed: December 8, 2017
    Publication date: June 14, 2018
    Inventors: Zhongyuan Zhu, Fanfeng Ma, Mu Zhu, Xiyuan Zhu