Abstract: Compounds are provided herein that can promote expression of a specific gene, SCN1A. In some aspects, provided herein are compositions, methods, and kits relating to the compounds disclosed herein. In some aspects, compounds provided herein can target the alternative splicing events in SCN1A gene and can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such compounds can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: An image reconstruction method, device and apparatus and non-transitory computer-readable storage medium are disclosed. The method may include: determining norms of convolution kernels of each convolutional layer of a deep neural network model; determining the convolution kernels with norms greater than or equal to a preset threshold in each convolutional layer to obtain a target convolution kernel set of each convolutional layer; processing an input image of each convolutional layer by using the convolution kernels in the target convolution kernel set of each convolutional layer respectively, to obtain a first image processing result; obtaining a second image processing result by performing interpolation on an initial image; and determining a fusion result according to the first image processing result and the second image processing result and reconstructing the initial image according to the fusion result.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: This disclosure is directed to an image authenticity detection method and apparatus. The method includes: obtaining an image; removing low-frequency information from the image to obtain first image information of the image; denoising the first image information to obtain second image information; determining, based on a difference between the first image information and the second image information, a fixed pattern noise feature map corresponding to the image; analyzing distribution of fixed pattern noise in the fixed pattern noise feature map, the fixed pattern noise being inherent noise from a camera sensor and not interfered by image content; and detecting, based on the distribution, authenticity of the image to obtain an authenticity detection result of the image.

Abstract: The present application provides a method and a network device for identifying a type of a wireless hotspot. The method comprises: in response to receiving a type determination request for a first wireless hotspot, obtaining information of the first wireless hotspot, wherein the type determination request is configured to request that a type of the first wireless hotspot be provided; searching for a second wireless hotspot which is identical or similar to the first wireless hotspot based on the information of the first wireless hotspot and information of multiple second wireless hotspots in a preset set of hotspots, wherein a type of the second wireless hotspot is an open wireless hotspot with authentication required; and in response to locating a second wireless hotspot which is identical or similar to the first wireless hotspot, identifying the type of the first wireless hotspot as an open wireless hotspot with authentication required.

Abstract: An image reconstruction method, device and apparatus and non-transitory computer-readable storage medium are disclosed. The method may include: determining norms of convolution kernels of each convolutional layer of a deep neural network model; determining the convolution kernels with norms greater than or equal to a preset threshold in each convolutional layer to obtain a target convolution kernel set of each convolutional layer; processing an input image of each convolutional layer by using the convolution kernels in the target convolution kernel set of each convolutional layer respectively, to obtain a first image processing result; obtaining a second image processing result by performing interpolation on an initial image; and determining a fusion result according to the first image processing result and the second image processing result and reconstructing the initial image according to the fusion result.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: The present application provides a method and a network device for identifying a type of a wireless hotspot. The method comprises: in response to receiving a type determination request for a first wireless hotspot, obtaining information of the first wireless hotspot, wherein the type determination request is configured to request that a type of the first wireless hotspot be provided; searching for a second wireless hotspot which is identical or similar to the first wireless hotspot based on the information of the first wireless hotspot and information of multiple second wireless hotspots in a preset set of hotspots, wherein a type of the second wireless hotspot is an open wireless hotspot with authentication required; and in response to locating a second wireless hotspot which is identical or similar to the first wireless hotspot, identifying the type of the first wireless hotspot as an open wireless hotspot with authentication required.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.

Abstract: Alternative splicing events in SCN1A gene can lead to non-productive mRNA transcripts which in turn can lead to aberrant protein expression, and therapeutic agents which can target the alternative splicing events in SCN1A gene can modulate the expression level of functional proteins in Dravet Syndrome patients and/or inhibit aberrant protein expression. Such therapeutic agents can be used to treat a condition caused by SCN1A, SCN8A or SCN5A protein deficiency.