Patents by Inventor Zhouxin Shen

Zhouxin Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20110190157
    Abstract: A molecular classification procedure based on activity levels of modules in protein networks, wherein the proteins are biomarkers for chronic lymphocytic leukemia (CLL), and method for use of the subnetworks to distinguish between patients at low or high risk of progression of their disease.
    Type: Application
    Filed: August 14, 2009
    Publication date: August 4, 2011
    Inventors: Thomas J. Kipps, Zhouxin Shen, Steven P. Briggs, Trey Ideker, Laura Rassenti, Han-Yu Chuang
  • Patent number: 7645613
    Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: January 12, 2010
    Assignee: Becton, Dickinson and Company
    Inventors: Richard M. Ivey, Thomas M. Gentle, Jr., Richard L. Moore, Michael L. Towns, Gary Siuzdak, Elizabeth J. Want, Zhouxin Shen, Nicholas Bachur, Jr., Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice
  • Patent number: 7632685
    Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
    Type: Grant
    Filed: December 28, 2006
    Date of Patent: December 15, 2009
    Assignee: Becton, Dickinson and Company
    Inventors: Richard M. Ivey, Thomas M. Gentle, Jr., Richard L. Moore, Michael L. Towns, Nicholas Bachur, Jr., Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
  • Publication number: 20080073512
    Abstract: Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1, or O—SiR1, R2, R3 wherein R1, R2, and R3 are selected from the group consisting of alkyl, alkenyl, alkynyl, aromatic, amino alkyl, amino alkenyl, amino alkynyl, pyridinyl, pyrridonyl, and carbonyl, alcohol and carboxylic acid derivatives thereof having one to twenty five atoms, and hydroxyl, amino, amide, carboxyl, ester, carbonyl, sulfhydryl, sulfonyl, phosphoral, bromo, iodo, chloro and fluoro derivatives. The letter “n” represents an integer from 1 to infinity and any vacant valences are silicon atoms, hydrogen or impurities.
    Type: Application
    Filed: July 27, 2007
    Publication date: March 27, 2008
    Applicant: WATERS INVESTMENTS LIMITED
    Inventors: Gary Siuzdak, Eden Go, Zhouxin Shen, Bruce Compton, Edouard Bouvier, Grace Credo
  • Publication number: 20080050829
    Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
    Type: Application
    Filed: December 28, 2006
    Publication date: February 28, 2008
    Inventors: Richard Ivey, Thomas Gentle, Richard Moore, Michael Towns, Nicholas Bachur, Robert Rosenstein, James Nadeau, Paul Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
  • Publication number: 20070184512
    Abstract: Mass spectrometry techniques for determining the status of sepsis in an individual are provided. A biomarker profile resolved from a biological sample, taken from the individual, using a mass spectrometry technique is compared to a reference biomarker profile. A single such comparison classifies the individual as belonging to or not belonging to a reference population. The individual's biomarker profile and the reference biomarker profile comprise a plurality of ions each having a mass-to-charge ratio of about 100 Daltons to about 1000 Daltons. The plurality of ions can be detected by electrospray ionization mass spectrometry in positive mode. The comparison uses a decision rule, such as a classification tree, that determines the status of sepsis in the individual without requiring knowledge of the identity of the biomarkers in the biomarker profile from the individual and without requiring knowledge of the identity of the biomarkers in the reference biomarker profile.
    Type: Application
    Filed: December 28, 2006
    Publication date: August 9, 2007
    Applicant: Becton, Dickinson and Company
    Inventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
  • Publication number: 20060157648
    Abstract: Embodiments of the present invention are directed to a substrate for performing ionization desorption on porous silicon, methods for performing such ionization desorption and methods of making substrates. One embodiment directed to a substrate for performing ionization desorption on silicon comprises a substrate having a surface having a formula of: As used above, X is H or Y, where at least at least twenty five mole percent of X is Y and Y is hydroxyl, or —O—R1 or O—SiR1,R2,R3 wherein R1,R2, and R3 are selected from the group consisting C1 to C6 straight, cyclic, or branched alkyl, aryl, or alkoxy group, a hydroxyl group, or a siloxane group, and R6 may be a C1 to C36 straight, cyclic, or branched alkyl (e.g.
    Type: Application
    Filed: November 29, 2005
    Publication date: July 20, 2006
    Applicant: WATERS INVESTMENTS LIMITED
    Inventors: Gary Siuzdak, Eden Go, Zhouxin Shen, Bruce Compton, Edouard Bouvier, Grace Credo
  • Publication number: 20060157647
    Abstract: A liquid chromatography configuration providing at least three dimensions of separation coupled with spectrometry greatly improves the ability to detect ions present in samples, including complex biological samples such as blood. Liquid chromatography columns in one embodiment are connected with an in-line trapping column the alternately communicates with the second and third liquid chromatography columns. The liquid chromatography columns are operably connected either to a mass spectrometer (MS) or a nuclear magnetic resonance (NMR) spectrometer. The improved dynamic range of detection allows a method of detecting molecular components present in complex biological samples that serve as biomarkers for a disease state, such as sepsis.
    Type: Application
    Filed: January 18, 2005
    Publication date: July 20, 2006
    Applicant: Becton, Dickinson and Company
    Inventors: Gary Siuzdak, Zhouxin Shen
  • Publication number: 20040157242
    Abstract: The early prediction or diagnosis of sepsis advantageously allows for clinical intervention before the disease rapidly progresses beyond initial stages to the more severe stages, such as severe sepsis or septic shock, which are associated with high mortality. Early prediction or diagnosis is accomplished by comparing an individual's profile of biomarker expression to profiles obtained from one or more control, or reference, populations, which may include a population who develops sepsis. Recognition of features in the individual's biomarker profile that are characteristic of the onset of sepsis allows a clinician to diagnose the onset of sepsis from a bodily fluid isolated at the individual at a single point in time. The necessity of monitoring the patient over a period of time is, therefore, avoided, advantageously allowing clinical intervention before the onset of serious symptoms.
    Type: Application
    Filed: November 12, 2003
    Publication date: August 12, 2004
    Applicant: Becton, Dickinson and Company
    Inventors: Richard M. Ivey, Thomas M. Gentle, Richard L. Moore, Michael L. Towns, Nicholas Bachur, Robert W. Rosenstein, James G. Nadeau, Paul E. Goldenbaum, Song Shi, Donald Copertino, James Garrett, Gregory Tice, Gary Siuzdak, Elizabeth Want, Zhouxin Shen
  • Publication number: 20030057106
    Abstract: A method of making improved substrates for desorbing and ionizing analytes takes an n-type semiconductor substrate and provides a strong light source. By focusing the illumination from the light source onto the n-type semiconductor substrate results in at least one lit region on the n-type semiconductor substrate. The substrate is electrochemically etched with a low current during illumination to form at least one sample reservoir, each sample reservoir being formed at a respective lit region on the n-type semiconductor substrate.
    Type: Application
    Filed: September 12, 2002
    Publication date: March 27, 2003
    Inventors: Zhouxin Shen, Gary Siuzdak