Patents by Inventor Zhu Tao

Zhu Tao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250073269
    Abstract: Provided is a catenated VAR2CSA recombinant protein, a preparation therefor and a use thereof. The catenated VAR2CSA recombinant protein comprises a binding domain, SpyTag, a p53dim structural domain, and SpyCatcher, which are randomly arranged. The binding domain comprises a structural domain, in the VAR2CSA protein, binding to placenta-like chondroitin sulfate A. The catenated VAR2CSA recombinant protein has high stability and affinity to the tumor-specific antigen placenta-like chondroitin sulfate A, and can be effectively used in the field of tumor immunotherapy, such as immune cell therapy.
    Type: Application
    Filed: June 9, 2022
    Publication date: March 6, 2025
    Inventors: Wen Hu, Zhu Tao, Wenzhong Guo, Wenting Ding, Li Qin, Xiaoping Chen
  • Patent number: 12221475
    Abstract: Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.
    Type: Grant
    Filed: November 29, 2017
    Date of Patent: February 11, 2025
    Assignee: CAS Lamvac (Guangzhou) Biomedical Technology Co., Ltd.
    Inventors: Wen Hu, Yongchao Yao, Wenzhong Guo, Yinbo Jiang, Shuozhou Huang, Ting Jiang, Jiaojiao Li, Zhu Tao, Yanli Gu, Huihui Zhang, Li Qin, Xiaoping Chen
  • Publication number: 20240207328
    Abstract: Provided are the use of Plasmodium in the preparation of an anti-tumor preparation for use in combination with radiotherapy and a Plasmodium anti-tumor preparation for use in combination with radiotherapy.
    Type: Application
    Filed: March 19, 2021
    Publication date: June 27, 2024
    Inventors: Zhu Tao, Wenting Ding, Zhipeng Cheng, Yinfang Feng, Li Qin, Xiaoping Chen
  • Publication number: 20230110635
    Abstract: A drug for preventing and/or treating a brain tumor and an application thereof. The drug comprises Plasmodium. The drug has significant preventive and/or therapeutic effects on a brain tumor, and is capable of inhibiting the growth of the brain tumor and prolonging the life span of a patient, and has no obvious side effects and has a high safety level. The drug expands treatment methods for brain tumors. Due to the specificity and sensitivity of brain tissues, chemotherapeutic drugs cannot easily cross the blood-brain barrier and exert anti-tumor effects. The drug mainly regulates the immunological functions and inflammation-related factors of the body to break through the blood-brain barrier by fully activating immunocompetence and inhibiting the growth of a brain tumor, thereby extending lifespan.
    Type: Application
    Filed: July 1, 2020
    Publication date: April 13, 2023
    Inventors: Zhu Tao, Wenting Ding, Zhipeng Cheng, Yinfang Feng, Li Qin, Xiaoping Chen
  • Publication number: 20220249643
    Abstract: An anti-neoplastic combined pharmaceutical composition and application thereof. The combined pharmaceutical composition is prepared from plasmodia and chemotherapeutic drugs. The combined pharmaceutical composition combines chemotherapy with Plasmodium immunotherapy, has high biosafety, has stronger antineoplastic activity than single chemotherapy or single Plasmodium immunotherapy, can prolong the lifetime of cancer patients, and provides a new strategy and idea for cancer treatment. Moreover, the dosage of the chemotherapy drugs can be reduced, toxic and side effects caused by the chemotherapy drugs are reduced, and treatment costs of tumor patients are reduced. In addition, the combined pharmaceutical composition can promote release of a tumor antigen, induces a stronger anti-tumor specific immune response, and exerts the continuous synergistic effect of immunotherapy and chemotherapy.
    Type: Application
    Filed: June 29, 2020
    Publication date: August 11, 2022
    Inventors: Zhu Tao, Zhongkui Kang, Li Qin, Xiaoping Chen
  • Publication number: 20210221880
    Abstract: Provided are a chimeric antigen receptor and an application thereof; said chimeric antigen receptor contains a domain which identifies any one of, or a combination of at least two of, the malarial protein VAR2CSA, a protein tag on malarial protein VAR2CSA, or a compound capable of labeling the malarial protein VAR2CSA. The chimeric antigen receptor can identify the VAR2CSA protein or the recombinant protein (rVAR2) of any one of, or at least two of, the domains of the VAR2CSA protein which can bind to placental-like chondroitin sulfate A (pl-CSA). The VAR2CSA protein or rVAS2 protein is capable of targeting several different types of tumor cells by means of binding to the pl-CSA on the surface of the tumor cell.
    Type: Application
    Filed: November 29, 2017
    Publication date: July 22, 2021
    Inventors: Wen Hu, Yongchao Yao, Wenzhong Guo, Yinbo Jiang, Shuozhou Huang, Ting Jiang, Jiaojiao Li, Zhu Tao, Yanli Gu, Huihui Zhang, Li Qin, Xiaoping Chen
  • Publication number: 20130333059
    Abstract: The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject.
    Type: Application
    Filed: September 26, 2012
    Publication date: December 12, 2013
    Applicant: THE JOHNS HOPKINS UNIVERSITY
    Inventors: Saraswati Sukumar, Zhu Tao, Xinyan Wu, Hexin Chen
  • Publication number: 20100285031
    Abstract: The present invention relates to compositions to treat HOXB7 related disorders. The invention also relates to methods treating HOXB7 related disorders. The invention further relates to kits for treating HOXB7 related disorders in a subject. The invention further relates to methods of identifying novel treatments for treating HOXB7 related disorders in a subject.
    Type: Application
    Filed: May 21, 2007
    Publication date: November 11, 2010
    Applicant: The Johns Hopkins University
    Inventors: Saraswati Sukumar, Zhu Tao, Xinyan Wu, Hexin Chen