Patents by Inventor Zhu Teng
Zhu Teng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11958863Abstract: The present disclosure includes compounds, kits, and assay procedures for use in determining the levels of certain types of drugs in samples that contain specific binding proteins for the drugs. The present disclosure includes analog compounds useful for displacing the drugs from their endogenous binding proteins, and kits including same, as well as methods that utilize these displacers as binding competitors in pharmaceutical assays.Type: GrantFiled: October 25, 2019Date of Patent: April 16, 2024Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Tie Wei, Zhu Teng, Martin Drinan, Jie Li
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Publication number: 20230204580Abstract: The invention relates to a formulation for total and differential counting of leukocytes for use in clinical analyses, in particular hemograms, to promote instantaneous differential staining of leukocytes in liquid medium, allowing greater practicality and agility in the total and differential counting of leukocytes. The practicality and agility are related to the use of a single dye for two parameters, eliminating the need for a smear. It results in a satisfactory effect for staining cells in suspension, staining the nucleus and cytoplasm of leukocytes in different shades, allowing their visualization under an optical microscope or in Point-of-Care image processing devices. It uses easily accessible raw materials, including cresyl acetate violet, ethyl alcohol, sodium and potassium chlorides, sodium hydroxide, acetic acid, triton X and deionized water, presenting a simple manufacturing process and low cost.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Applicant: Hi Technologies Ltda.Inventors: Marcus Vinicius MAZEGA FIGUEREDO, Sergio Renato ROGAL JÚNIOR, Aléxía THAMARA GASPARIN, Claudiane ISABEL FRANCO ARAUJO, Erika BERGAMO SANTIAGO, Luis Felipe HARTMANN, Adriano Artur TIMM, Ivan LUCAS REIS SILVA, Flavia ZHU TENG, João Victor PREDEBON
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Publication number: 20230204487Abstract: The invention relates to a formulation for counting and morphological-based inference of erythrocytes and platelets to for use in clinical analyses, in particular hemograms, with the purpose of counting both erythrocytes and platelets in a liquid medium, and performing qualitative inferences of erythrocyte and platelet morphology, through image processing in Point-of-Care devices or through an optical microscope. This formulation preserves the natural morphological characteristics of erythrocytes and platelets, and uses methylparaben, propylparaben, sodium chloride, sodium bicarbonate, bovine serum albumin (BSA), sodium citrate, potassium citrate, K2EDTA and deionized water, which is advantageous in terms of operational simplicity and low cost.Type: ApplicationFiled: December 21, 2022Publication date: June 29, 2023Applicant: Hi Technologies Ltda.Inventors: Marcus Vinicius MAZEGA FIGUEREDO, Sergio Renato Rogal Júnior, Aléxia Thamara Gasparin, Claudiane Isabel Franco Araujo, Erika Bergamo Santiago, Luis Felipe Hartmann, Adriano Artur Timm, Ivan Lucas Reis Silva, Flavia Zhu Teng, João Victor Predebon
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Publication number: 20220373500Abstract: Improved formulation(s), device(s), and method(s) for producing ion-selective electrodes (ISEs) that comprise at least one photo-curable, epoxy-based, ion-selective chloride membrane(s) compounds that can be pre-mixed together to form a singularly-dispensed mixture for the formation of an ion-exchange resin membrane(s) for incorporation and use in a chloride ISE.Type: ApplicationFiled: October 30, 2020Publication date: November 24, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Kyoung Ha Cha, Zhu Teng, Si Yang
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Publication number: 20220049018Abstract: Antibodies that specifically bind naloxone or naltrexone are disclosed. Also disclosed are conjugates used in the production of the antibodies, as well as methods of producing the antibodies. Also disclosed are methods of using the antibodies in direct assays for naloxone or naltrexone. Further disclosed are methods of reducing naloxone or naltrexone interference in opiate assays using the antibodies.Type: ApplicationFiled: January 30, 2020Publication date: February 17, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Manoj Sharma, Tatiana Lebedeva, Tatiana Mareeva, Yuriy Smirnov, Bogdan Draghici, Zhu Teng, Yi Feng Zheng, Heungyeung Yau, Nihmat Morjana, William Bedzyk, Allison Dominowski
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Publication number: 20220024946Abstract: Compositions comprising binding competitors that can be used in assays for macrophilin-binding pharmaceuticals in samples are disclosed, as well as kits containing same and methods of use thereof.Type: ApplicationFiled: October 25, 2019Publication date: January 27, 2022Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Wei, Zhu Teng, Martin Drinan, Jie Li
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Publication number: 20210311031Abstract: The present invention relates to methods and compositions to remove or reduce biotin interference from certain assays.Type: ApplicationFiled: September 19, 2019Publication date: October 7, 2021Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Wei, Zhu Teng, Izak Bahar
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Publication number: 20210247398Abstract: Kits containing a chemiluminescent detection system and microfluidics devices and methods for determining the concentration of biotin in a sample are disclosed. The kits, microfluidics devices, and methods utilize a sensitizer capable of generating singlet oxygen in its excited state and having avidin or an analog thereof directly or indirectly bound thereto, as well as a singlet oxygen-activatable chemiluminescent compound having biotin or an analog thereof directly or indirectly bound thereto.Type: ApplicationFiled: July 24, 2019Publication date: August 12, 2021Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Q. Wei, Zhu Teng, Xiaodong Liu, Martin Drinan
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Patent number: 10399938Abstract: The present invention discloses compositions that comprise compounds relating to vitamin D. These compounds are useful for assays in the determination and distinguishing of certain 3-epimeric 25 hydroxyvitamin D and non-epimeric 25 hydroxyvitamin D. The compositions of the present invention may be used for example as immunogens used to develop antibodies to certain vitamin D compounds or conjugates used in assays for certain vitamin D compounds or used as a solid phase reagent in assays. The composition comprises a compound of one or more of the generic formula (R1)p-(L)q-Z.Type: GrantFiled: September 19, 2018Date of Patent: September 3, 2019Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Patent number: 10203344Abstract: Compounds include carbamate derivatives of vitamin D including vitamin D3 and vitamin D2. The compounds are useful in methods and kits for determining the presence and/or amount of vitamin D including vitamin D analogs and metabolites thereof in a sample suspected of containing the same.Type: GrantFiled: December 16, 2015Date of Patent: February 12, 2019Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Roland Janzen, Martin A. Drinan
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Publication number: 20190016677Abstract: Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as defined herein.Type: ApplicationFiled: September 19, 2018Publication date: January 17, 2019Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Patent number: 10106498Abstract: This invention relates to compositions, methods and kits for determining the presence and/or amount of vitamin D analytes, including vitamin D isomers, and metabolites thereof in a sample suspected of containing the same. Compounds include compounds of the Formula I, namely, (R1)p-(L)q-Z wherein R1, L, p and q are as defined herein. These compounds are capable of binding specifically to corresponding antibodies. Compounds and antibodies in accordance with the principles described herein can have therapeutic activity. These compounds may be administered in therapeutically effective amount, which is an amount to provide treatment of a particular disease state associated with vitamin D. Administration of the examples of compounds in accordance with the principles described herein can be by means of any of the accepted modes of administration for agents that serve similar utilities.Type: GrantFiled: June 22, 2015Date of Patent: October 23, 2018Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Qimu Liao, Manoj Sharma, Martin A. Drinan, Tie Quan Wei
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Publication number: 20180180623Abstract: Compositions are disclosed that include a support having on a surface thereof at least an inner polysaccharide layer and an outer polysaccharide layer. The outer polysaccharide layer has pendant moieties each comprising a terminal amine functionality. The point of linkage of the pendant moiety to the outer polysaccharide layer does not comprise an amide bond. The composition may be employed in a method of conjugating a member of a specific binding pair to a particle. The method comprises reacting the terminal amine functionality of the composition with the member of the specific binding pair, which comprises an amine-reactive functionality.Type: ApplicationFiled: February 19, 2018Publication date: June 28, 2018Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Liping Geng, Martin Drinan
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Patent number: 9815907Abstract: Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.Type: GrantFiled: June 22, 2015Date of Patent: November 14, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Manoj Sharma, Tatiana Mareeva, Yuriy Smirnov, William D. Bedzyk, Zhu Teng, Tie Quan Wei
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Patent number: 9804176Abstract: Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.Type: GrantFiled: June 22, 2015Date of Patent: October 31, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Zhu Teng, Tatiana Mareeva, Jie Li, Martin A. Drinan, Izak Bahar, Manoj Sharma
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Patent number: 9746484Abstract: Methods include determining an amount of vitamin D analyte in a sample suspected of containing the vitamin D analyte. A combination is provided in an assay medium that includes the sample, a vitamin D epimer antibody that is specific for epimers of the vitamin D analyte wherein the vitamin D epimer antibody does not bind to any detectable degree to the vitamin D analyte, and a vitamin D antibody that is specific for the vitamin D analyte, and. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimers of the vitamin D analyte and for binding of the vitamin D antibody to the vitamin D analyte to form a vitamin D antibody-bound complex. The amount of vitamin D antibody-bound complex is determined and related to the amount of vitamin D analyte in the sample.Type: GrantFiled: June 22, 2015Date of Patent: August 29, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Jie Li, Manoj Sharma, Zhu Teng
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Patent number: 9726681Abstract: Methods of detecting Cortisol in samples suspected of containing Cortisol are disclosed that utilize conjugates of 11-a-cortisol linked at the 3-position to an assay molecule. In addition, compounds are disclosed that have the formula: (structure) wherein L is a linking group and X is as further defined herein.Type: GrantFiled: August 6, 2014Date of Patent: August 8, 2017Assignee: Siemens Healthcare Diagnostics Inc.Inventors: Zhu Teng, Lauren Seiple, Martin Drinan
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Publication number: 20170168076Abstract: Methods include determining an amount of vitamin D analyte in a sample suspected of containing the vitamin D analyte. A combination is provided in an assay medium that includes the sample, a vitamin D epimer antibody that is specific for epimers of the vitamin D analyte wherein the vitamin D epimer antibody does not bind to any detectable degree to the vitamin D analyte, and a vitamin D antibody that is specific for the vitamin D analyte, and. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimers of the vitamin D analyte and for binding of the vitamin D antibody to the vitamin D analyte to form a vitamin D antibody-bound complex. The amount of vitamin D antibody-bound complex is determined and related to the amount of vitamin D analyte in the sample.Type: ApplicationFiled: June 22, 2015Publication date: June 15, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Jie Li, Manoj Sharma, Zhu Teng
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Publication number: 20170153254Abstract: Methods include determining an amount of an epimeric vitamin D analyte in a sample suspected of containing the epimeric vitamin D analyte. A combination is provided in an assay medium that includes the sample and a vitamin D epimer antibody that is specific for the epimeric vitamin D analyte. The assay medium is incubated under conditions for binding of the vitamin D epimer antibody to the epimeric vitamin D analyte to form an epimeric vitamin D antibody-bound complex. The amount of the epimeric vitamin D antibody-bound complex is determined and related to the amount of epimeric vitamin D analyte in the sample.Type: ApplicationFiled: June 22, 2015Publication date: June 1, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Tie Quan Wei, Zhu Teng, Tatiana Mareeva, Jie Li, Martin A. Drinan, Izak Bahar, Manoj Sharma
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Publication number: 20170121426Abstract: Antibodies are raised against compounds of Formula (I) where Z is an immunogenic carrier. These compounds are capable of binding specifically to corresponding antibodies. The antibodies are specific for epimers of vitamin D. Antibodies in accordance with the principles described herein may be employed to minimize or eliminate 3-epimer cross-reactivity in assays for non-epimeric forms of vitamin D analytes. Over-estimation of total non-epimeric vitamin D analyte caused by the cross-reactivity of 3-epimer vitamin D with an antibody for vitamin D analyte can be substantially avoided employing, as blocking agents, antibodies prepared against immunogens that are a compound of the Formula (I) wherein Z is an immunogenic carrier.Type: ApplicationFiled: June 22, 2015Publication date: May 4, 2017Applicant: Siemens Healthcare Diagnostics Inc.Inventors: Manoj Sharma, Tatiana Mareeva, Yuriy Smirnov, William D. Bedzyk, Zhu Teng, Tie Quan Wei