Patents by Inventor Zhuang DUAN

Zhuang DUAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATOR PURINE-DERIVED COMPOUNDS, CONJUGATES THEREOF, AND METHODS OF USE THEREOF
    Publication number: 20250170266
    Abstract: Purine-derived compounds of Formulae (I)-(IV), immunostimulatory antibody conjugates (ISACs) comprising such compounds, as well as methods for producing and using such compounds, e.g., for the treatment of diseases such as cancer, are disclosed.
    Type: Application
    Filed: January 21, 2025
    Publication date: May 29, 2025
    Inventors: Graham Albert Edwin Garnett, Truman Hirkala-Schaefer, Michael G. Brant, Raffaele Colombo, Zhuang Duan, Stuart Daniel Barnscher
  • ANTIBODY CONSTRUCTS BINDING 4-1BB AND FOLATE RECEPTOR ALPHA AND USES THEREOF
    Publication number: 20230265202
    Abstract: Described herein are antibody constructs comprising a 4- 1BB binding domain and an anti-Folate Receptor a (FRa) antigen- binding domain, wherein the 4-1BB-binding domain and the FR? antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function. The antibody constructs are used in the treatment of a subject having cancer.
    Type: Application
    Filed: April 9, 2021
    Publication date: August 24, 2023
    Inventors: Daniel T. PATTON, Lee FREIBURGER, Thomas SPRETER VON KREUDENSTEIN, David M. MILLS, Gesa VOLKERS, Dunja UROSEV, Zhuang DUAN, Elizabeth HALVORSEN, Harsh PRATAP, Brandon CLAVETTE, Anna VON ROSSUM, Patricia ZWIERZCHOWSKI, Peter Wing Yiu CHAN, Danny CHUI, Sylwia JANCOWSKI, Sukhbir Singh KANG, Grant Raymond Wickman
  • ANTIBODY CONSTRUCTS BINDING 4-1BB AND TUMOR-ASSOCIATED ANTIGENS AND USES THEREOF
    Publication number: 20230052369
    Abstract: Described herein are antibody constructs comprising a 41-1BB binding domain and an antigen-binding domain that binds to a tumor-associated antigen (TAA), wherein the 4-1BB-binding domain and the TAA antigen-binding domain are linked directly or indirectly to a scaffold. The scaffold may be an Fc construct with modifications that reduce its ability to mediate effector function.
    Type: Application
    Filed: April 9, 2021
    Publication date: February 16, 2023
    Inventors: Daniel T. PATTON, David M. MILLS, Thomas SPRETER VON KREUDENSTEIN, Gesa VOLKERS, Dunja UROSEV, Lee FREIBURGER, Zhuang DUAN, Elizabeth HALVORSEN, Harsh PRATAP, Brandon CLAVETTE, Anna VON ROSSUM, Duncan BROWMAN, Peter Wing Yiu CHAN, Danny CHUI, Robert William GENE, Sylwia JANCOWSKI, Sukhbir Singh KANG, Patricia ZWIERZCHOWSKI