Patents by Inventor Zhuang Jin

Zhuang Jin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for treating or preventing bacterial infections
    Patent number: 12286418
    Abstract: The disclosure relates, in certain aspects, to compounds that can be used to inhibit ?-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of ?-lactamases in vitro and in vivo.
    Type: Grant
    Filed: June 20, 2020
    Date of Patent: April 29, 2025
    Assignee: Baylor College of Medicine
    Inventors: Timothy Palzkill, Doris Taylor, Justin Anglin, Nicholas Simmons, John Faver, Yong Wang, Zhuang Jin, Martin Matzuk
  • ASH1L INHIBITORS AND METHODS AND TREATMENT THEREWITH
    Publication number: 20240245645
    Abstract: Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
    Type: Application
    Filed: January 8, 2024
    Publication date: July 25, 2024
    Inventors: Jolanta GREMBECKA, Tomasz CIERPICKI, David ROGAWSKI, Dmitry BORKIN, Szymon KLOSSOWSKI, Zhuang JIN, Deanna MONTGOMERY, Jing DENG, Marta KROTOSKA, Hao LI
  • ASH1L inhibitors and methods of treatment therewith
    Patent number: 11883381
    Abstract: Provided herein are small molecule inhibitors of ASH1L activity and small molecules that facilitate ASH1L degradation and methods of use thereof for the treatment of disease, including acute leukemia, solid cancers and other diseases dependent on activity of ASH1L.
    Type: Grant
    Filed: May 12, 2017
    Date of Patent: January 30, 2024
    Assignee: The Regents of the University of Michigan
    Inventors: Jolanta Grembecka, Tomasz Cierpicki, David Rogawski, Dmitry Borkin, Szymon Klossowski, Zhuang Jin, Deanna Montgomery, Jing Deng, Marta Krotoska, Hao Li
  • Compounds and Methods for Treating or Preventing Bacterial Infections
    Publication number: 20220267303
    Abstract: The disclosure relates, in certain aspects, to compounds that can be used to inhibit ?-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of ?-lactamases in vitro and in vivo.
    Type: Application
    Filed: June 20, 2020
    Publication date: August 25, 2022
    Inventors: Timothy Palzkill, Doris Taylor, Justin Anglin, Nicholas Simmons, John Faver, Yong Wang, Zhuang Jin
  • Compounds, compositions, pharmaceutical compositions, and methods of use
    Patent number: 9492428
    Abstract: Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
    Type: Grant
    Filed: November 16, 2012
    Date of Patent: November 15, 2016
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Gerald B. Hammond, Zhuang Jin, Paula J. Bates, Elsa Merit Reyes-Reyes, Abraham Vaisberg
  • COMPOUNDS, COMPOSITIONS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE
    Publication number: 20150025129
    Abstract: Certain embodiments of the invention include compositions comprising a compound of Formula (I), and salts, isomers, and derivatives thereof. Pharmaceutical compositions of some embodiments of the present invention comprise a compound of Formula (I), and salts, isomers, and derivatives thereof. Other embodiments of this invention include methods for treating disease (e.g., cancer) and methods for administering a compound of Formula (I), and salts, isomers, and derivatives thereof.
    Type: Application
    Filed: November 16, 2012
    Publication date: January 22, 2015
    Inventors: Gerald B. Hammond, Zhuang Jin, Paula J. Bates, Elsa Merit Reyes-Reyes, Abraham Vaisberg