Patents by Inventor Zhui Chen

Zhui Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11149021
    Abstract: An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 19, 2021
    Assignee: ABBISKO THERAPEUTICS CO., LTD.
    Inventors: Baowei Zhao, Mingming Zhang, Hongping Yu, Shuqun Yang, Zhui Chen, Yaochang Xu
  • Patent number: 11130762
    Abstract: An azaaryl derivative with the structure of formula (I), a preparation method therefor and a pharmaceutical use thereof are disclosed in this application. The series of compounds of the this application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary site tumor metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: September 28, 2021
    Assignee: ABBISKO THERAPEUTICS CO., LTD.
    Inventors: Baowei Zhao, Mingming Zhang, Hongping Yu, Zhui Chen, Yaochang Xu
  • Publication number: 20210261544
    Abstract: A compound having a structure of formula (I) and a preparation method therefor, and a use of the compound serving as an FGFR inhibitor for treating tumors, cancers, myeloproliferative diseases, bone or chondrocyte disorders, and hypophosphatemia.
    Type: Application
    Filed: July 23, 2019
    Publication date: August 26, 2021
    Inventors: Haibing DENG, Hongping YU, Zhui CHEN, Yaochang XU
  • Publication number: 20210130323
    Abstract: Formylpyridine derivatives having FGFR4 inhibitory activities, a preparation method therefor and use thereof are described. In particular, the formylpyridine derivatives have a structure of formula (I), and the definition of each substituent in the formula are described in the description and claims. The series of compounds of the formula (I) have very strong inhibitory effects on FGFR4 kinases and very high selectivity, and can be widely used in the preparation of medicaments for treating cancers, particularly prostate cancer, liver cancer, pancreatic cancer, esophageal cancer, stomach cancer, lung cancer, breast cancer, ovarian cancer, colon cancer, skin cancer, neuroglioblastoma or rhabdomyosarcoma, and prospectively will be further developed to become a new generation of FGFR4 inhibitors.
    Type: Application
    Filed: August 1, 2018
    Publication date: May 6, 2021
    Inventors: Haibing DENG, Fei YANG, Hongping YU, Zhui CHEN, Yaochang XU
  • Patent number: 10968220
    Abstract: Provided are an FGFR4 inhibitor having the structure of formula (I), and a preparation method therefor and the use thereof. The compound has a very strong inhibitory effect on FGFR4 kinase activity and has a very high selectivity, and can be widely used in the preparation of a drug for treating cancers, especially prostate cancer, liver cancer, pancreatic cancer, esophageal carcinomas, gastric cancer, lung cancer, breast cancer, ovarian carcinomas, colon cancer, skin cancer, glioblastomas or rhabdomyosarcomas, and is expected to be developed into a new generation of FGFR4 inhibitor drugs.
    Type: Grant
    Filed: December 14, 2017
    Date of Patent: April 6, 2021
    Assignee: ABBISKO THERAPEUTICS CO., LTD.
    Inventors: Fei Yang, Haibing Deng, Haiyan Ying, Hongping Yu, Zhui Chen, Yaochang Xu
  • Publication number: 20210032270
    Abstract: Disclosed are a biaryl derivative having a structure represented by Formula (I) and inhibitory activity against PD-1/PD-L1 interaction, a preparation method thereof, and a pharmaceutical application thereof. The series of compounds of the can be widely applied to the preparation of a medicament for preventing and/or treating cancer or tumors, immune-related diseases and disorders, contagious diseases, infectious diseases or metabolic diseases that are mediated by a PD-1/PD-L1 signaling pathway, and shows promise for the development of a new generation of PD-1/PD-L1 inhibitors.
    Type: Application
    Filed: January 29, 2019
    Publication date: February 4, 2021
    Applicant: Abbisko Therapeutics Co., Ltd.
    Inventors: Fei YANG, Yongxian ZHANG, Haiyan YING, Hongping YU, Zhui CHEN, Yaochang XU
  • Publication number: 20200165254
    Abstract: An azaaryl derivative with the structure of formula (I), a preparation method therefor and a pharmaceutical use thereof are disclosed in this application. The series of compounds of the this application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary site tumor metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.
    Type: Application
    Filed: May 22, 2018
    Publication date: May 28, 2020
    Inventors: Baowei ZHAO, Mingming ZHANG, Hongping YU, Zhui CHEN, Yaochang XU
  • Publication number: 20200140431
    Abstract: This application describes a nitrogen heteroaryl derivative having CSF1R inhibitory activity, and a preparation method therefor and an application thereof. Compounds in the present invention has a structure represented by formula (I) as below, and the definition on substituents is as stated in the description and the claims. The compounds in the this application can be widely applied to preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease, or metastatic disease, in particular ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, metastasis of primary tumor sites, or osseous metastatic cancer, and a new generation of CSF1R inhibitor drugs is expected to be developed.
    Type: Application
    Filed: June 13, 2018
    Publication date: May 7, 2020
    Inventors: Mingming ZHANG, Baowei ZHAO, Hongping YU, Zhui CHEN, Yaochang XU
  • Publication number: 20200071302
    Abstract: An N-(azaaryl)cyclolactam-1-carboxamide derivative having a structure of formula (I), a preparation method therefor, and a use thereof are disclosed in the application. Each substituent are defined in the specification and claims. The series of compounds of the application can be widely applied in the preparation of drugs for treating cancer, tumor, autoimmune disease, metabolic disease or metastatic disease, particularly for treating ovarian cancer, pancreatic cancer, prostate cancer, breast cancer, cervical cancer, glioblastoma, multiple myeloma, metabolic disease, neurodegenerative disease, primary tumor site metastasis or osseous metastasis cancer, and are expected to be developed into a new generation of CSF-1R inhibitor drugs.
    Type: Application
    Filed: May 22, 2018
    Publication date: March 5, 2020
    Inventors: Baowei ZHAO, Mingming ZHANG, Hongping YU, Shuqun YANG, Zhui CHEN, Yaochang XU
  • Publication number: 20190270742
    Abstract: Provided are an FGFR4 inhibitor having the structure of formula (I), and a preparation method therefor and the use thereof. The compound has a very strong inhibitory effect on FGFR4 kinase activity and has a very high selectivity, and can be widely used in the preparation of a drug for treating cancers, especially prostate cancer, liver cancer, pancreatic cancer, esophageal carcinomas, gastric cancer, lung cancer, breast cancer, ovarian carcinomas, colon cancer, skin cancer, glioblastomas or rhabdomyosarcomas, and is expected to be developed into a new generation of FGFR4 inhibitor drugs.
    Type: Application
    Filed: December 14, 2017
    Publication date: September 5, 2019
    Inventors: Fei YANG, Haibing DENG, Haiyan YING, Hongping YU, Zhui CHEN, Yaochang XU
  • Publication number: 20160271821
    Abstract: A vegetable processor having a drum-like container with an inner cylindrical cavity shaped and sized to house a plurality of vegetables. The cavity has an inlet shaped and sized to allow vegetables to pass into the cavity there through, and an outlet positioned at least in part on the side of the container and shaped and sized to allow portions of said plurality of vegetables placed in the cavity to extend out of the cavity through the outlet. A pair of blade, positioned transverse to one another are attached to the side of the drum at the outlet. Vegetables in the drum are forced against the blades and out of the inner cavity by a set of paddles that rotate within the cavity, such that the blades substantially simultaneously cut the vegetables being processed in more than one direction.
    Type: Application
    Filed: March 20, 2015
    Publication date: September 22, 2016
    Inventor: Zhui Chen
  • Patent number: 7377201
    Abstract: A food processing apparatus comprises a first and second shaft and first, second, third and fourth subsets of blades. The first and second subsets of blades are mounted to the first shaft. The blades of the first subset of blades are separated by a first displacement. The blades of the second subset of blades are separated by a second displacement differing from the first displacement. The third and fourth subsets of blades are mounted to the second shaft. The blades of the third subset of blades are separated by the first displacement. The blades of the fourth subset of blades are separated by the second displacement. The first and third subset of blades form a first cutting region for cutting food to a first dimension and the second and fourth subset of blades form a second cutting region for cutting food to a second dimension.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: May 27, 2008
    Inventor: Zhui Chen
  • Publication number: 20060196334
    Abstract: A food processing apparatus for slicing food into slices, strips and cubes comprises a frame, a first and second shaft and first, second, third and fourth subsets of blades. The first shaft is coupled to the frame for rotation relative to the frame about a longitudinal axis of the first shaft. The second shaft is coupled to the frame for rotation relative to the frame about a longitudinal axis of the second shaft. The longitudinal axis of the second shaft is disposed substantially parallel to the longitudinal axis of the first shaft and is displaced therefrom. The first and second subsets of blades are mounted to the first shaft. Each blade of the first subset of blades is displaced along the longitudinal axis of the first shaft from adjacent blades of the first subset of blades by a first displacement.
    Type: Application
    Filed: March 3, 2005
    Publication date: September 7, 2006
    Inventor: Zhui Chen