Patents by Inventor Zhuming Zhang

Zhuming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250051355
    Abstract: The present disclosure provides compounds for modulating calcitonin receptor and/or amylin receptor activity, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating a calcitonin receptor and/or amylin receptor associated disease or disorder.
    Type: Application
    Filed: August 6, 2024
    Publication date: February 13, 2025
    Inventors: Hui LEI, Cui LI, Chunliang LU, Ding XUE, Haizhen ZHANG, Zhuming ZHANG, Evelyne HOUANG, Jian LIU, Zhe NIE, Anatoly RUVINSKY, Eric THERRIEN
  • COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20250042916
    Abstract: The present disclosure provides compounds for modulating calcitonin receptor and/or amylin receptor activity, as well as pharmaceutical compositions comprising the compounds disclosed herein. Also provided are methods for treating a calcitonin receptor and/or amylin receptor associated disease or disorder.
    Type: Application
    Filed: August 5, 2024
    Publication date: February 6, 2025
    Inventors: Hui LEI, Cui LI, Chunliang LU, Ding XUE, Haizhen ZHANG, Zhuming ZHANG, Jian LIU
  • TREATMENT OF MYELOPROLIFERATIVE DISEASES AND DISORDERS WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN
    Publication number: 20240226096
    Abstract: Disclosed are methods of treating myeloproliferative neoplasms, diseases, and disorders.
    Type: Application
    Filed: December 7, 2023
    Publication date: July 11, 2024
    Inventors: Andrew William Stamford, AnthonyM. Barsitti, Zhuming Zhang, Mehmet Kahraman, Robert L. Davis, Andrew Shiau
  • TREATMENT OF GRAFT-VERSUS-HOST DISEASE WITH INHIBITORS OF BET FAMILY BDII BROMODOMAIN
    Publication number: 20240217952
    Abstract: Disclosed are methods of treating graft-versus-host disease.
    Type: Application
    Filed: December 7, 2023
    Publication date: July 4, 2024
    Inventors: Andrew William Stamford, Anthony M. Barsotti, Zhuming Zhang, Mehmet Kahraman, Andrew Shiau
  • FLUORINATED QUINOLINE, QUINOXALINE AND BENZO[B][1,4]OXAZINE DERIVATIVES AS DIHYDROOROTATE DEHYDROGENASE (DHODH) INHIBITORS FOR THE TREATMENT OF CANCER, AUTOIMMUNE AND INFLAMMATORY DISEASES
    Publication number: 20240166622
    Abstract: Disclosed are compounds, compositions, and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein X, Y, R1a, R1b, Z1, Z2, Z3, R2, and R3, are defined herein.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 23, 2024
    Inventors: Justin Cisar, Scott Kuduk, Aihua Wang, Zhuming Zhang, Chao-yuan Wang
  • SMALL MOLECULES FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20240132524
    Abstract: Disclosed are compounds, compositions, and methods useful for boron neutron capture therapy.
    Type: Application
    Filed: September 20, 2023
    Publication date: April 25, 2024
    Inventors: Andrew William Stamford, Zhuming Zhang
  • SMALL MOLECULES FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20240067665
    Abstract: Disclosed are compounds, compositions, and methods useful for boron neutron capture therapy.
    Type: Application
    Filed: August 10, 2023
    Publication date: February 29, 2024
    Inventors: Andrew William Stamford, Zhuming Zhang
  • Dihydroorotate dehydrogenase inhibitors
    Patent number: 11753393
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: September 12, 2023
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • Dihydroorotate dehydrogenase inhibitors
    Patent number: 11505536
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: November 22, 2022
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20220298137
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 22, 2022
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20220081422
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Embodiments of such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5a, R5b, X and Y, are defined herein.
    Type: Application
    Filed: February 6, 2020
    Publication date: March 17, 2022
    Inventors: Justin Cisar, Scott Kuduk, Zhuming Zhang, Aihua Wang, Yvan Simonnet
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10981926
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: April 20, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20200331881
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Application
    Filed: April 16, 2020
    Publication date: October 22, 2020
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • Substituted Thiohydantoin Derivatives As Androgen Receptor Antagonists
    Publication number: 20200109150
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: November 8, 2019
    Publication date: April 9, 2020
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10501469
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: December 10, 2019
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20190337924
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1a, R2a, R2b, Z, X, Y, and G are defined herein.
    Type: Application
    Filed: June 13, 2019
    Publication date: November 7, 2019
    Inventors: Gilles Bignan, Peter J Connolly, Jan Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B Trabalón Escolar
  • SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20190330190
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1, R2a, R2b, Z, X, Y, and G are defined herein.
    Type: Application
    Filed: June 13, 2019
    Publication date: October 31, 2019
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted Thiohydantoin Derivatives As Androgen Receptor Antagonists
    Publication number: 20180298021
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 18, 2018
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10000502
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: June 19, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B Trabalón Escolar
  • SUBSTITUTED THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20170233401
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: January 11, 2017
    Publication date: August 17, 2017
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar