Patents by Inventor Zhuming Zhang

Zhuming Zhang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SMALL MOLECULES FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20240132524
    Abstract: Disclosed are compounds, compositions, and methods useful for boron neutron capture therapy.
    Type: Application
    Filed: September 20, 2023
    Publication date: April 25, 2024
    Inventors: Andrew William Stamford, Zhuming Zhang
  • SMALL MOLECULES FOR BORON NEUTRON CAPTURE THERAPY
    Publication number: 20240067665
    Abstract: Disclosed are compounds, compositions, and methods useful for boron neutron capture therapy.
    Type: Application
    Filed: August 10, 2023
    Publication date: February 29, 2024
    Inventors: Andrew William Stamford, Zhuming Zhang
  • Dihydroorotate dehydrogenase inhibitors
    Patent number: 11753393
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Grant
    Filed: May 12, 2022
    Date of Patent: September 12, 2023
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • Dihydroorotate dehydrogenase inhibitors
    Patent number: 11505536
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Grant
    Filed: April 16, 2020
    Date of Patent: November 22, 2022
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20220298137
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Application
    Filed: May 12, 2022
    Publication date: September 22, 2022
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20220081422
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Embodiments of such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, R5a, R5b, X and Y, are defined herein.
    Type: Application
    Filed: February 6, 2020
    Publication date: March 17, 2022
    Inventors: Justin Cisar, Scott Kuduk, Zhuming Zhang, Aihua Wang, Yvan Simonnet
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10981926
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: April 20, 2021
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • DIHYDROOROTATE DEHYDROGENASE INHIBITORS
    Publication number: 20200331881
    Abstract: Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1, R2, R3, R4, X, and Y are defined herein.
    Type: Application
    Filed: April 16, 2020
    Publication date: October 22, 2020
    Inventors: Scott Kuduk, Zhuming Zhang, Lindsey DeRatt, Aihua Wang
  • Substituted Thiohydantoin Derivatives As Androgen Receptor Antagonists
    Publication number: 20200109150
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: November 8, 2019
    Publication date: April 9, 2020
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10501469
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: June 19, 2018
    Date of Patent: December 10, 2019
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20190337924
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1a, R2a, R2b, Z, X, Y, and G are defined herein.
    Type: Application
    Filed: June 13, 2019
    Publication date: November 7, 2019
    Inventors: Gilles Bignan, Peter J Connolly, Jan Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B Trabalón Escolar
  • SUBSTITUTED HYDANTOIN AND THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20190330190
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1, R2a, R2b, Z, X, Y, and G are defined herein.
    Type: Application
    Filed: June 13, 2019
    Publication date: October 31, 2019
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted Thiohydantoin Derivatives As Androgen Receptor Antagonists
    Publication number: 20180298021
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: June 19, 2018
    Publication date: October 18, 2018
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • Substituted thiohydantoin derivatives as androgen receptor antagonists
    Patent number: 10000502
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Grant
    Filed: January 11, 2017
    Date of Patent: June 19, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gilles Bignan, Peter J Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B Trabalón Escolar
  • SUBSTITUTED THIOHYDANTOIN DERIVATIVES AS ANDROGEN RECEPTOR ANTAGONISTS
    Publication number: 20170233401
    Abstract: Disclosed are compounds, compositions and methods for treating of disorders that are affected by the antagonism of one or more androgen receptor types. Such compounds are represented by Formula (I) as follows: wherein R1 and G are defined herein.
    Type: Application
    Filed: January 11, 2017
    Publication date: August 17, 2017
    Inventors: Gilles Bignan, Peter J. Connolly, Ian Hickson, Lieven Meerpoel, Vineet Pande, Zhuming Zhang, Jonathan Branch, Christian Rocaboy, Luis B. Trabalón Escolar
  • 4?-azido, 3?-fluoro substituted nucleoside derivatives as inhibitors of HCV RNA replication
    Patent number: 9708357
    Abstract: The present invention relates to the use of 3?-fluoro, 4?-azido nucleoside phosphoramidate prodrug derivatives of formula I wherein the symbols are as defined in the specification, to pharmaceutically acceptable salts thereof, and to pharmaceutical compositions containing such compounds for the treatment of HCV.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: July 18, 2017
    Assignee: Riboscience, LLC
    Inventors: Mark Smith, Francisco Xavier Talamas, Jing Zhang, Zhuming Zhang
  • Method of Treating Dengue Fever
    Publication number: 20160168186
    Abstract: The application provides methods for treatment or prophylaxis of dengue virus mediated diseases with compounds of Formula I wherein R1, R2a, R2b, R3, R4, R5 R6, R8a, R9 and R10 are as defined herein. The application further discloses methods for treatment or prophylaxis of dengue virus mediated diseases with pharmaceutical compositions comprising compounds of Formula I.
    Type: Application
    Filed: October 9, 2015
    Publication date: June 16, 2016
    Inventors: Hassan Javanbakht, Klaus G. Klumpp, Suping Ren, Zhuming Zhang
  • 2?, 4?-difluoro-2?-methyl substituted nucleoside derivatives as inhibitors of HCV RNA replication
    Patent number: 9108999
    Abstract: The present disclosure relates to compounds of Formula (I): Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of using the compounds of Formula (I) and/or compositions comprising the compounds of Formula (I) for the treatment of HCV.
    Type: Grant
    Filed: December 17, 2012
    Date of Patent: August 18, 2015
    Assignee: Riboscience LLC
    Inventors: Jing Zhang, Zhuming Zhang
  • Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
    Patent number: 9045486
    Abstract: The present invention relates to a compound having the general formula (I), optionally in the form of a pharmaceutically acceptable salt, solvate, polymorph, codrug, cocrystal, prodrug, tautomer, racemate, enantiomer, or diastereomer or mixture thereof, which are useful in treating, ameloriating or preventing a viral disease. Furthermore, specific combination therapies are disclosed.
    Type: Grant
    Filed: January 7, 2014
    Date of Patent: June 2, 2015
    Assignees: Savira pharmaceuticals GmbH, European Molecular Biology Laboratory, F. Hoffman-La Roche AG
    Inventors: Andrea Wolkerstorfer, Oliver Szolar, Norbert Handler, Helmut Buschmann, Stephen Cusack, Mark Smith, Sung-Sau So, Ronald Charles Hawley, Achyutharao Sidduri, Zhuming Zhang
  • 2'-4'-DIFLUORO-2'-METHYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION
    Publication number: 20150004135
    Abstract: The present disclosure relates to compounds of Formula (I): Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of using the compounds of Formula (I) and/or compositions comprising the compounds of Formula (I) for the treatment of HCV.
    Type: Application
    Filed: December 17, 2012
    Publication date: January 1, 2015
    Applicants: HOFFMAN-LA ROCHE INC., RIBOSCIENCE LLC
    Inventors: Jing Zhang, Zhuming Zhang