Abstract: Systems and methods of message filtering in a multi-region multi-active architecture are provided. A client device receives a data message, the data message comprising a region tag and an account tag. The client device determines whether the region tag corresponds to a region server assigned to serve the client device. In response to determining the region tag corresponds to the region server assigned to serve the client device, the client device determines whether an account identification (ID) associated with the client device matches the account tag of the data message. In response to determining the account ID matches the account tag, the client device consumes the data message.

Abstract: The present disclosure provides for multi-specific antibodies and antigen-binding fragments thereof that bind to human MUC1 and CD16A, pharmaceutical compositions comprising said antibodies, and use of the antibodies or the compositions for treating a disease, such as cancer.

Abstract: A computer implemented method processes audio streams recorded during a meeting by a plurality of distributed devices.

Abstract: Examples of array geometry agnostic multi-channel personalized speech enhancement (PSE) extract speaker embeddings, which represent acoustic characteristics of one or more target speakers, from target speaker enrollment data. Spatial features (e.g., inter-channel phase difference) are extracted from input audio captured by a microphone array. The input audio includes a mixture of speech data of the target speaker(s) and one or more interfering speaker(s). The input audio, the extracted speaker embeddings, and the extracted spatial features are provided to a trained geometry-agnostic PSE model. Output data is produced, which comprises estimated clean speech data of the target speaker(s) that has a reduction (or elimination) of speech data of the interfering speaker(s), without the trained PSE model requiring geometry information for the microphone array.

Abstract: A modified cell, a method for preparing a modified cell, and a use thereof in treatment of a disease. The modified cell comprises a polynucleotide that encodes a presenting peptide, wherein the polynucleotide is under the transcriptional regulation of an endogenous B2M gene.

Abstract: Disclosed herein are fusion proteins having a ?2M polypeptide and a presenting peptide, and nucleic acids that encode such fusion proteins. Provided herein are also genetically engineered cells expressing such fusion protein, methods of their production, and their uses in allogeneic transplant. CAR-T cells expressing fusion protein disclosed herein and their uses in cancer treatment are also disclosed.

Abstract: Disclosed are a method for controlling an outrigger of a pump truck, a method for controlling the pump truck and the pump truck. The method for controlling the outrigger of the pump truck of the present disclosure includes: obtaining a first tilting angle of an entire pump truck after a boom is unfolded; and in a case that the first tilting angle is larger than or equal to a first preset value, obtaining a current error count, and controlling the outrigger to act based on the current error count.

Abstract: The present invention relates to a proliferation enhancer. The enhancer comprises a protein molecule capable of initiating the cellular STATS and/or STAT3 signaling pathway and comprising the intracellular domain, the transmembrane domain and the extracellular domain. The present invention further relates to a lymphocyte expressing the proliferation enhancer and the use thereof as an immunotherapy drug.