Abstract: The present invention relates to a novel compound and application thereof in the inhibition of HBV gene expression. The structure of the compound comprises an interfering nucleic acid for inhibiting HBV gene expression, transition points, and delivery chains of the interfering nucleic acid. By means of the delivery chains, two or three N-acetylgalactosamines can be introduced to an antisense strand 3? end of such siRNA, and two or one N-acetylgalactosamine can be correspondingly introduced to a sense strand 5? end, the total number of the introduced N-acetylgalactosamines being four. In vitro and in vivo pharmacological experiments prove that such a novel compound can continuously and efficiently inhibit HBV gene expression.

Abstract: Implementations of the present disclosure provide a memory device, an operation method thereof, and a memory system. The memory device may include a memory cell array including a plurality of blocks. The memory device may include a peripheral circuit coupled to the memory cell array. The peripheral circuit may be configured to apply a plurality of different erasure verification voltages to a selected block among the plurality of blocks after applying a first effective erasure voltage to the selected block. The peripheral circuit may be configured to determine a second effective erasure voltage applied to the selected block according to a plurality of erasure verification results corresponding to the plurality of different erasure verification voltages. The second effective erasure voltage may be greater than the first effective erasure voltage.

Abstract: The invention relates to a composition comprising (A) a heterophasic propylene copolymer, (B) a propylene homopolymer and (C) a polyolefin-based elastomer, wherein (A) the heterophasic propylene copolymer consists of (al) a propylene-based matrix, wherein the propylene-based matrix consists of a propylene homopolymer and/or a propylene copolymer consisting of at least 90 wt % of propylene monomer units and at most 10 wt % of ethylene and/or ?-olefin monomer units, based on the total weight of the propylene-based matrix and (a2) a dispersed ethylene-?-olefin copolymer, wherein the sum of the total amount of propylene-based matrix and total amount of the dispersed ethylene-?-olefin copolymer in the heterophasic propylene copolymer is 100 wt %, (C) the polyolefin-based elastomer has a melt flow index of 15 to 50 dg/min measured according to ASTM D1238 with a 2.16 kg load at 190° C., the total amount of (a2) and (C) with respect to the total composition is 20.0 to 26.

Abstract: A dual-pulse MIG welding power source based on SiC power devices may include a main circuit and a digital control circuit. The main circuit may include a power frequency rectifier filter module, a first SiC high frequency inverter module, a first high frequency transformer, and a first SiC fast full-wave rectifier filter module connected sequentially. The power frequency rectifier filter module may be connected to a three-phase AC power supply, and the first SiC fast full-wave rectifier filter module may be connected to a load. The digital control circuit may include a digital human-machine interaction module, a core control module, a SiC high-frequency drive module, a load voltage and current detection feedback module, and a wire feeding control module. The digital human-machine interaction module may be connected to the core control module.

Abstract: The present disclosure provides a construction method of a risk prediction model for a prognosis of gastric cancer, and belongs to the technical field of biomedicine. In the present disclosure, from the perspective of bioinformatics analysis, it is predicted that gastric cancer exosomes carry circRNAs. Markers regulating the occurrence and development of gastric cancer are selected by combining the circRNAs with an RNA binding protein (RBP). A predictive marker for the prognosis of gastric cancer is an RPB gene, including one or more of AUH, HNRNPC, HNRNPD, U2AF2, and FXR1. The risk prediction model constructed based on the predictive marker can quickly and accurately predict the prognosis of patients with gastric cancer.

Abstract: The present disclosure discloses an optical lens and a camera module, from an object side to an imaging plane along an optical axis, sequentially including: a first group, a second group, and protective glass. The first group has a positive focal power and sequentially includes, from the object side to the imaging plane along the optical axis, a first substrate and a first lens bonded together. The object side surface or image side surface of the first substrate is coated with a stop. The second group has a negative focal power and sequentially includes, from the object side to the image side along the optical axis, a second lens, a second substrate, and a third lens bonded together. The working object distance of the optical lens is from 5 mm to infinity.

Abstract: Embodiments are provided for managing the operation of sensors in an electronic device. According to certain aspects, the electronic device may detect a change in motion from a set of lower-sensitivity sensor data generated by a sensor(s) operating in a lower-sensitivity mode. When the change in motion is detected and during a timeout window, the sensor(s) may generate an additional set of lower-sensitivity sensor data and a set of higher-sensitivity sensor data. The electronic device may initially confirm the change in motion based on analyzing the set of higher-sensitivity sensor data. Further, the electronic device may determine that the additional set of lower-sensitivity does not indicate an additional change in motion, and may deem the confirmation of the change in motion as a false positive.

Abstract: A water exchange base station including a main body, a sewage exchange port, a clear water exchange port, a first sewage connecting port, a first clear water connecting port arranged on the main body, and an inlet valve; when the clear water port of the intelligent cleaning machine is docked with the clear water exchange port and in the state of supplying clear water, the clear water exchange port supplies the clear water to the intelligent cleaning machine; when the sewage port of the intelligent cleaning machine is docked with the sewage exchange port and in the state of sewage discharging, the sewage inside the intelligent cleaning machine is drawn out from the sewage exchange port and discharged from the first sewage connecting port to the outside.

Abstract: A quantum dot film includes a target color quantum dot film and a residual non-target color quantum dot film, wherein a ligand for the target color quantum dot of the target color quantum dot film is an oil-soluble ligand, and a ligand for the residual non-target color quantum dot of the residual non-target color quantum dot film is selected from any one or more of halogen ions and short-chain organic ligands whose carbon chain length is in a range of 2 to 18 carbons.

Abstract: Systems and methods are described herein to automate managing of service layer operations comprised of multiple elementary operations and offloading the burden of performing such multi-step operations from a requesting entity to the service layer. A Request Abstraction Service (RAS) is described herein for the autonomous execution of such multi-step operations. Methods and apparatuses are also described herein for a service layer framework for integrating generic and functional user interfaces as services managed by the SL on behalf of requesting entities.

Abstract: Provides are an ultrasonic transducer, a fabrication method thereof and an electronic device. The ultrasonic transducer includes: an array substrate having a groove, a bottom electrode and an insulation layer, wherein an orthographic projection of the groove on the array substrate is within an orthographic projection of the bottom electrode on the array substrate, and the insulation layer covers the bottom electrode; and an opposite substrate, the opposite substrate and the array substrate are oppositely arranged and are attached to each other, the opposite substrate and the array substrate form a cavity in the groove, the opposite substrate has a top electrode and a vibrating diaphragm layer which are arranged in stack, and an orthographic projection of the top electrode on the array substrate is within the orthographic projection of the bottom electrode on the array substrate.

Abstract: A safety pin locking device for workpiece turnover includes a safety pin, a triangular lock plate, an elastic positioning pin, and a lockset. The safety pin is configured to be inserted into a base and an overturnable workpiece to lock an angle of the overturnable workpiece relative to the base. A first corner end of the triangular lock plate is connected to an axial surface of the safety pin by a fastener, and the triangular lock plate can rotate around the fastener. The elastic positioning pin is mounted at a second corner end of the triangular lock plate and is configured to be inserted into positioning counterbores at two different positions on the axial surface of the safety pin to limit a position of the triangular lock plate. The lockset is mounted at a third corner end of the triangular lock plate.

Abstract: An audio coding method and apparatus are provided. The audio coding method includes: obtaining first audio data; obtaining a target bit rate and a Bluetooth packet type, where the target bit rate and the Bluetooth packet type correspond to a current status of a Bluetooth channel; obtaining one or more of a bit pool parameter set, a psychoacoustic parameter set, and a spectrum bandwidth parameter set by using a neural network obtained through pre-training based on the first audio data, the target bit rate, and the Bluetooth packet type; and coding the first audio data based on one or more of the bit pool parameter set, the psychoacoustic parameter set, and the spectrum bandwidth parameter set to obtain a to-be-sent bit stream. The status of the Bluetooth channel can be adaptively matched, and continuous audio listening experience is provided when audio quality is maximally ensured.

Abstract: The disclosure herein describes using a transcript generation model for generating a transcript from a multi-speaker audio stream. Audio data including overlapping speech of a plurality of speakers is obtained and a set of frame embeddings are generated from audio data frames of obtained audio data using an audio data encoder. A set of words and channel change (CC) symbols are generated from the set of frame embeddings using a transcript generation model. The CC symbols are included between pairs of adjacent words that are spoken by different people at the same time. The set of words and CC symbols are transformed into a plurality of transcript lines, wherein words of the set of words are sorted into transcript lines based on CC symbols, and a multi-speaker transcript is generated based on the plurality of transcript lines. The inclusion of CC symbols by the model enables efficient, accurate multi-speaker transcription.

Abstract: A method and a related device for unlocking a smart lock are provided, and may be applied to an intelligent vehicle or a self-driving vehicle, to implement an unlocking function of a smart lock of the vehicle. The method includes: A terminal device monitors a distance change trend between the terminal device and an intelligent device, where the intelligent device includes a smart lock. If the terminal device determines that the terminal device is approaching the intelligent device and a distance between the terminal device and the intelligent device is less than a first distance threshold, the terminal device enables an identity authentication process between the terminal device and the intelligent device. The terminal device unlocks the smart lock when identity authentication between the terminal device and the intelligent device succeeds.

Abstract: Methods, systems, and computer programs encoded on a computer storage medium, for training and using machine learning models are disclosed. Methods include creating a model that represents relationships between user attributes, content exposures, and performance levels for a target action using organic exposure data specifying one or more organic exposures experienced by a particular user over a specified time prior to performance of a target action by the particular user and third party exposure data specifying third party exposures of a specified type of digital component to the particular user over the specified time period. Using the model, an incremental performance level attributable to each of the third party exposures at an action time when the target action was performed by the particular user is determined. Transmission criteria for at least some digital components to which the particular user was exposed are modified based on the incremental performance.

Abstract: The present invention discloses a coating device including: a first shell, having a top portion and a side portion; and a second shell, accommodated in the first shell and at least partially divergently extending downwards from the top portion of the first shell. The first shell and the second shell define a first space in between, the second shell defines a second space, and the first space surrounds the second space and the two are not in communication.

Abstract: This disclosure provides a method, apparatus and electronic device for information processing. A specific implementation of the method includes: receiving a first setting operation performed by a first user on a first session message in a target session, wherein the first user is a member of the target session, and the first session message comprises one or more session messages in the target session; in response to the first setting operation, changing a first operation permission of at least part of members of the target session on the first session message to a second operation permission; wherein a permission scope of the second operation permission is less than a permission scope of the first operation permission.

Abstract: Provided is an endoscope lens, a camera module and an endoscope. From an object side to an image side, the endoscope lens sequentially includes: a first lens having a concave object side surface and a convex image side surface; a second lens with a positive or negative refractive power; and a filter arranged between the second lens and the image side. Each of the first lens and the second lens is a glass or plastic aspheric lens. The endoscope lens further includes a stop positioned between the first lens and the object side or between the first lens and the second lens.