Abstract: The present application discloses a method, system, and computer system for managing lineage data for data entities. The method includes generating lineage data, wherein generating the lineage data, and storing and indexing, in a data structure, the lineage data in association with the selected data entity. The generating the lineage data includes selecting a selected data entity, obtaining a query tree that was used to generate the selected data entity, and determining lineage data for the selected data entity based at least in part on the query tree.

Abstract: The present disclosure relates to a new use of anlotinib, and relates in particular to anlotinib inhibiting osteosarcoma and chondrosarcoma growth and metastasis. It has been discovered for the first time that anlotinib can inhibit osteosarcoma and chondrosarcoma growth and metastasis. Anlotinib can significantly inhibit the growth of the osteosarcoma cell lines 143B, U2OS, MG63 and SJSA, induce cycle arrest in said cell lines, and can also inhibit osteosarcoma cell line migration and invasion. It has also been discovered for the first time that anlotinib can enhance the killing effect of the chemotherapeutic drug cisplatin on osteosarcoma cells.