Abstract: Provided herein are compounds of Formula (I): or a pharmaceutically acceptable salt thereof. The provided compounds are useful Poly ADP-ribose glycohydrolase (PARG) inhibitors. Additional utilities and advantages are described herein.

Abstract: A display panel, a crack detection method and a display device are provided. The display panel includes a substrate, a signal wiring disposed over the substrate, and a test wiring insulated from the signal wiring and disposed on a side of the signal wiring facing away from the substrate. An orthographic projection of the test wiring on the substrate overlaps an orthographic projection of the signal wiring on the substrate. The display panel also includes a first test terminal disposed over the substrate and electrically connected with an end of the test wiring, and a second test terminal disposed over the substrate and electrically connected with another end of the test wiring.

Abstract: Disclosed are a manufacturing method of a display panel, a display panel and a display device. The manufacturing method includes the following steps: providing a base substrate; forming a planarization layer on a side of the base substrate; forming a first film layer on a side of the planarization layer facing away from the base substrate; forming an anode via penetrating through the first film layer and the planarization layer; forming an anode layer on a side of the first film layer facing away from the base substrate; patterning the anode layer to form a first opening on the anode layer; and after patterning the anode layer, patterning the first film layer to form a second opening on the first film layer. A material of the first film layer includes a non-metallic material.

Abstract: A display panel, a method for fabrication a display panel, and a display device are provided. The display panel includes a display area, and a non-display area surrounding the display area and a first bezel area being in the non-display area; a substrate; a wiring layer, disposed on the substrate and in the non-display area, and including at least one first lead and at least one second lead, and at least a partial line segment of the at least one first lead and at least a partial line segment of the at least one second lead are disposed in the first bezel area; a polarizer disposed on a side of the wiring layer away from the substrate; and a first light-emitting layer, at least distributed in the first bezel area and, along a direction perpendicular to the substrate, disposed between the substrate and the wiring layer.

Abstract: A display panel, a crack detection method and a display device are provided. The display panel includes a substrate, a signal wiring disposed over the substrate, and a test wiring insulated from the signal wiring and disposed on a side of the signal wiring facing away from the substrate. An orthographic projection of the test wiring on the substrate overlaps an orthographic projection of the signal wiring on the substrate. The display panel also includes a first test terminal disposed over the substrate and electrically connected with an end of the test wiring, and a second test terminal disposed over the substrate and electrically connected with another end of the test wiring.

Abstract: A display panel, a method for fabrication a display panel, and a display device are provided. The display panel includes a display area, and a non-display area surrounding the display area and a first bezel area being in the non-display area; a substrate; a wiring layer, disposed on the substrate and in the non-display area, and including at least one first lead and at least one second lead, and at least a partial line segment of the at least one first lead and at least a partial line segment of the at least one second lead are disposed in the first bezel area; a polarizer disposed on a side of the wiring layer away from the substrate; and a first light-emitting layer, at least distributed in the first bezel area and, along a direction perpendicular to the substrate, disposed between the substrate and the wiring layer.

Abstract: The present disclosure discloses a display panel, a manufacturing method thereof and a display device. By arranging positions of first transmission pads and second transmission pads, and setting areas of first film layers in the first transmission pads to be less than those of second film layers, when the first transmission pads and the second transmission pads are disposed oppositely, fully-opened openings are formed between the two pads, so that it is convenient to fill spaces between the first transmission pads and the second transmission pads with conductive components to allow the first transmission pads be electrically connected with the second transmission pads through the conductive components, guaranteeing an effective electrical connection between the first transmission pads and the second transmission pads and then ensuring signal transmission via first wires and second wires through the first transmission pads and the second transmission pads.

Abstract: Disclosed are a manufacturing method of a display panel, a display panel and a display device. The manufacturing method includes the following steps: providing a base substrate; forming a planarization layer on a side of the base substrate; forming a first film layer on a side of the planarization layer facing away from the base substrate; forming an anode via penetrating through the first film layer and the planarization layer; forming an anode layer on a side of the first film layer facing away from the base substrate; patterning the anode layer to form a first opening on the anode layer; and after patterning the anode layer, patterning the first film layer to form a second opening on the first film layer. A material of the first film layer includes a non-metallic material.

Abstract: A display panel and a display device are provided. The display panel includes a display unit; a visual test component including test signal input terminals; a driving chip including display signal input terminals; and a plurality of signal lines configured to generate driving signals for the display unit. In a visual test phase, the visual test component is configured to provide signals to signal lines through test signal input terminals. In a display phase, the driving chip is configured to provide signals to the signal lines through the display signal input terminals. The visual test component includes at least one first switch connected to at least one signal line. A control terminal of the at least one first switch is connected to the driving chip. In the visual test phase, the at least one first switch is turned on for connection under a control of the visual test component.

Abstract: Display panel and display device are provided. The display panel includes a display region; a non-display region; and a notch. Data lines are disposed in the display region. An edge of the display panel recesses toward the display region to form the notch. The display region includes a first display region and second display regions. The notch and the first display regions are disposed between two second display regions in the first direction and are adjacent in the second direction. The data lines include first data lines in each of the second display regions separated by the notch. Connection lines are disposed surrounding the at least one notch, and each connection line connects two of the first data lines in a same column and on two sides of the notch At least a portion of the connection lines includes first segments disposed in the first display region.

Abstract: Display panel and display device are provided. The display panel includes a display region; a non-display region; and a notch. Data lines are disposed in the display region. An edge of the display panel recesses toward the display region to form the notch. The display region includes a first display region and second display regions. The notch and the first display regions are disposed between two second display regions in the first direction and are adjacent in the second direction. The data lines include first data lines in each of the second display regions separated by the notch. Connection lines are disposed surrounding the at least one notch, and each connection line connects two of the first data lines in a same column and on two sides of the notch. At least a portion of the connection lines includes first segments disposed in the first display region.

Abstract: The present disclosure discloses a display panel, a manufacturing method thereof and a display device. By arranging positions of first transmission pads and second transmission pads, and setting areas of first film layers in the first transmission pads to be less than those of second film layers, when the first transmission pads and the second transmission pads are disposed oppositely, fully-opened openings are formed between the two pads, so that it is convenient to fill spaces between the first transmission pads and the second transmission pads with conductive components to allow the first transmission pads be electrically connected with the second transmission pads through the conductive components, guaranteeing an effective electrical connection between the first transmission pads and the second transmission pads and then ensuring signal transmission via first wires and second wires through the first transmission pads and the second transmission pads.

Abstract: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Abstract: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Abstract: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Abstract: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Abstract: Compounds are provided having a structure according to Formula (I): wherein A1, A2, A3, Y, R1, R2, R3, R4, R5, R6, m, n and p are defined herein. Further provided are pharmaceutical compositions including the compounds provided and methods of making and using the compounds and compositions as provided, e.g., in the treatment and prevention of various disorders, such as Alzheimer's disease.

Abstract: The present invention provides compounds that are alpha4 integrin antagonists having a structure according to the following formula: or a tautomer, mixture of tautomers, salt or solvate thereof, wherein Cy, ring A, m, n, p, R1, R2, R3, R4, R5 and R6 are defined in the specification. The invention further provides pharmaceutical compositions including the compounds of the invention as well as methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various conditions and disorders, such as Crohn's disease and ulcerative colitis.

Abstract: Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.