Patents by Inventor ZIBO LI
ZIBO LI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240387967Abstract: A phase shifter and a method for preparing a phase shifter are provided. The phase shifter includes at least one phase shifter unit. The phase shifter unit includes a substrate; a first lead and a second lead on the substrate and spaced apart from each other; a bridging section on the first lead and the second lead, wherein the bridging section is connected to the first lead and the second lead; and a third lead on a side of the bridging section away from the substrate.Type: ApplicationFiled: July 28, 2022Publication date: November 21, 2024Applicant: BOE TECHNOLOGY GROUP CO., LTD.Inventors: Jianyun ZHAO, Jingwen GUO, Chunxin LI, Qianhong WU, Jianxing LIU, Zibo CAO, Feng QU
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Publication number: 20240325520Abstract: The present invention discloses a recombinant RBD trimer protein capable of simultaneously generating cross neutralization activity for various severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic strains. The RBD trimer protein is taken as an antigen and supplemented with an adjuvant to immunize an organism, so that a high-titer neutralizing antibody aiming at various SARS-CoV-2 epidemic strains can be generated at the same time, and the antibody has a certain broad-spectrum property and can be used for treating and/or preventing SARS-CoV-2 infection and/or coronavirus disease 2019.Type: ApplicationFiled: September 24, 2021Publication date: October 3, 2024Inventors: Qiming LI, Yu LIANG, Jing ZHANG, Jiguo SU, Zibo HAN, Shuai SHAO, Yanan HOU, Hao ZHANG, Shi CHEN, Yuqin JIN, Xuefeng ZHANG, Lifang DU, JunWei HOU, Zhijing MA, Zehua LEI, Fan ZHENG, Fang TANG, Zhaoming LIU, Ning LIU
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Publication number: 20240313399Abstract: The present disclosure provides an antenna unit and a multi-beam antenna. The antenna unit includes: a first dielectric substrate; a reference electrode layer; a first feed line and a radiation layer, the first feed line being electrically coupled to the radiation layer; and at least one layer of metasurface including a second dielectric substrate and at least one patch unit, the patch unit including a plurality of patch structures arranged at intervals and side by side. For any one of the patch units, an electromagnetic wave radiated by the radiation layer has different transmission phases after passing through the plurality of patch structures, and transmission phases of the plurality of patch structures increase or decrease sequentially.Type: ApplicationFiled: April 22, 2024Publication date: September 19, 2024Applicants: Beijing BOE Technology Development Co., Ltd., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Qianhong Wu, Jingwen Guo, Chunxin Li, Jianxing Liu, Zibo Cao, Jianyun Zhao
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Publication number: 20240279050Abstract: The present disclosure provides an MEMS switch device and an electronic apparatus. The MEMS switch device includes a base substrate, a membrane bridge structure, and a first ground line, a signal line and a second ground line sequentially arranged on a first side surface of the base substrate at intervals; the membrane bridge structure has a first end electrically connected to the first ground line, and a second end, opposite to the first end, electrically connected to the second ground line; and the membrane bridge structure includes a membrane bridge body structure and at least one protruding structure on the membrane bridge body structure, where the protruding structure protrudes from the membrane bridge body structure in a direction perpendicular to the first side surface of the base substrate.Type: ApplicationFiled: June 29, 2022Publication date: August 22, 2024Inventors: Zibo CAO, Yingli SHI, Jingwen GUO, Chunxin LI, Qianhong WU, Jianyun ZHAO, Jianxing LIU, Feng QU
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Publication number: 20240275009Abstract: A phase shifter includes: a first substrate; a signal electrode, a first reference electrode, and a second reference electrode which are on the first substrate; a first insulating layer covering at least a side of the signal electrode distal to the first substrate; and at least one film-bridge electrode group on a side of the first insulating layer distal to the signal electrode. Each film-bridge electrode group includes film-bridge electrodes insulated from each other, and an orthogonal projection of the signal electrode on the first substrate is between orthogonal projections of the first and second reference electrodes on the first substrate. An orthogonal projection of a bridge floor of each film-bridge electrode on the first substrate partially overlaps the orthogonal projection of the signal electrode. Distances between bridge floors of the film-bridge electrodes in a same film-bridge electrode group and the signal electrode are different from each other.Type: ApplicationFiled: January 25, 2022Publication date: August 15, 2024Inventors: Jianxing LIU, Jingwen GUO, Qianhong WU, Chunxin LI, Zibo CAO, Jianyun ZHAO, Feng QU
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Publication number: 20240266732Abstract: The disclosure provides a tunable antenna, a method for preparing the tunable antenna and an electronic device, wherein the tunable antenna includes a substrate, and a microstrip feeder and a plurality of antennas arranged at intervals on a side of the substrate, wherein the microstrip feeder is configured to provide a coupling signal; and a control switch, arranged between the microstrip feeder and the plurality of antennas, and/or between at least two adjacent antennas the plurality of antennas, wherein the control switch is configured to control conduction between the microstrip feeder and at least one of the plurality of antennas, so as to output the coupling signal provided by the microstrip feeder into electromagnetic waves of different frequency bands.Type: ApplicationFiled: June 29, 2022Publication date: August 8, 2024Applicants: BEIJING BOE TECHNOLOGY DEVELOPMENT CO., LTD., BOE TECHNOLOGY GROUP CO., LTD.Inventors: Chunxin Li, Jingwen Guo, Qianhong Wu, Zibo Cao, Feng Qu
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Publication number: 20240243457Abstract: The phase shifter includes a substrate; a first wire and second wires arranged on a side of the substrate, wherein two opposite sides of the first wire are respectively provided with the second wires, and the first wire and the second wires are arranged in parallel and insulated from each other; a hydrophobic conductive part, which is arranged crosswise with the first wire and is insulated from the first wire, and at least one end of the hydrophobic conductive part is overlapped with the second wire at one side of the first wire, and is insulated from the second wire; and a hydrophilic part, wherein a minimum distance between an orthographic projection of the hydrophilic part on the substrate and an orthographic projection of the hydrophobic conductive part that does not overlap with the second wires, in a first direction, is less than or equal to a preset value.Type: ApplicationFiled: January 4, 2022Publication date: July 18, 2024Applicant: BOE Technology Group Co., Ltd.Inventors: Zibo Cao, Jingwen Guo, Qianhong Wu, Chunxin Li, Jianxing Liu, Jianyun Zhao, Feng Qu
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Publication number: 20230345451Abstract: A multi-user scheduling method based on reinforcement learning for 5G IoT, including: calculating the achievable rate of each user in a set according to a communication scenario model; generating an initial scheduled users set according to the achievable rate of each user; according to the achievable rate of each user and the number of times each user is scheduled, evaluating the estimated value of each user's action value under the current scheduling period by using the Q-learning method; determining the upper bound value of the confidence interval of each user's action value; determining the set of scheduled users under the current scheduling period according to the upper bound of the confidence interval of each user's action value; according to the set of scheduled users under the current scheduling period, recalculating the actual achievable rate value of each selected user under the current scheduling period.Type: ApplicationFiled: January 13, 2023Publication date: October 26, 2023Applicant: State Grid Jiangsu Electric Power Co., LTD, Nanjing Power Supply BranchInventors: Wendi WANG, Hong ZHU, Pu WANG, Honghua XU, Su PAN, Dongxu ZHOU, Xin QIAN, Zibo LI, Xuanxuan SHI, Junkang WANG, Zhongzhong XU, Jun ZHAO
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Publication number: 20230023368Abstract: Radiosensitizer prodrugs and formulations and methods of use thereof are provided. Typically, the radiosensitizer prodrug is an analog of a radiosensitizer parent compound having one or more S-nitrosothiol moieties. Typically, the S—N bond of the S-nitrosothiol moiety can be cleaved by radiation during radiotherapy, releasing the parent compound and nitric oxide. One or preferably both the parent compound and the nitric oxide can contribute to death of tumor cells exposed to radiotherapy. Nanoparticle formulations for delivery of the prodrug, and methods of using them in combination with radiotherapy to treat tumors and cancer are also provided.Type: ApplicationFiled: November 5, 2020Publication date: January 26, 2023Inventors: Jin Xie, Anil Kumar, Zibo Li
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Publication number: 20220169581Abstract: The invention generally relates to methods of making substituted arenes via direct C—H, C—O, C—S, or C—N bond conversion and methods of synthesizing isotopically-labeled substituted arenes via direct carbon-halogen bond conversion. The invention also relates to anaerobic catalyst systems comprising an acridinium photocatalyst and a nucleophile selected from a halide, a cyanide, and an isotopically-labeled amine. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.Type: ApplicationFiled: February 27, 2020Publication date: June 2, 2022Inventors: Zibo Li, David Nicewicz, Wei Chen
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Publication number: 20220096539Abstract: Particles formed from an alkai metal or alkaline earth metal and halide, for example, sodium and chloride, are provided. The particles can have a hydrophilic coating or external layer, formed of, for example, a polyether-lipid conjugate. In preferred embodiments, the lipid is a phospholipid such as a phosphoethanolamine, and the polyether is a polyethylene glycol such as a PEG amine. Methods making the particles by, for example, a microemulsion reaction, are also provided. Pharmaceutical compositions including a plurality of particles and a pharmaceutically acceptable carrier are also disclosed. Typically the compositions include an effective amount of particles to treat a disease or condition, particularly cancer, in a subject in need thereof. The particles are typically nanoparticles, for example, between about 10 nm and 250 nm and can be monodisperse.Type: ApplicationFiled: January 17, 2020Publication date: March 31, 2022Inventors: Jin Xie, Wen Jiang, Trever Todd, Zibo Li
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Patent number: 11103603Abstract: The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.Type: GrantFiled: October 20, 2017Date of Patent: August 31, 2021Assignee: The University of North Carolina at Chapel HillInventors: Zibo Li, Zhanhong Wu, Ben Giglio, Stergios Moschos
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Patent number: 11065349Abstract: This invention provides a class of dual mode imaging tracer capable of acting both as a fluorescent imaging tracer and a positron emission tomography imaging tracer. Tracers in accordance with this invention generally have a fluorescent core with a boron-fluoride element embedded therein. Exemplary embodiments of the tracer include 18F-labeled BODIPY compounds and derivative thereof. Also provided are tracer kits containing a sterile formulation of a BODIPY dye either in a radio-labeled or pre-labeled state, and methods for imaging heart perfusion using the 18F-labeled dual mode tracers.Type: GrantFiled: March 15, 2013Date of Patent: July 20, 2021Inventors: Peter S. Conti, Zibo Li, Shuanglong Liu, Dan Li
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Publication number: 20200188540Abstract: Conformationally strained irans-cycloalkenes and derivatives thereof suitable for radiolabeling in a subject in need thereof.Type: ApplicationFiled: December 14, 2016Publication date: June 18, 2020Applicants: University of Delaware, The University of North Carolina at Chapel Hill, United Kingdom Research and InnovationInventors: Joseph FOX, Zibo LI, Yu LIU, Michael Thompson TAYLOR, Dennis SVATUNEK, Katarina ROHLFING, Mengzhe WANG, Zhanhong WU, Raghu VANNAM, Jason W. CHIN, Stephen WALLACE
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Patent number: 10646598Abstract: Disclosed is a class of versatile Sarcophagine based bifunctional chelators (BFCs) containing a hexa-aza cage for labeling with metals having either imaging, therapeutic or contrast applications radiolabeling and one or more linkers (A) and (B). The compounds have the general formula where A is a functional group selected from group consisting of an amine, a carboxylic acid, an ester, a carbonyl, a thiol, an azide and an alkene, and B is a functional group selected from the group consisting of hydrogen, an amine, a carboxylic acid, and ester, a carbonyl, a thiol, an azide and an alkene. Also disclosed are conjugate of the BFC and a targeting moiety, which may be a peptide or antibody. Also disclosed are metal complexes of the BFC/targeting moiety conjugates that are useful as radiopharmaceuticals, imaging agents or contrast agents.Type: GrantFiled: June 27, 2016Date of Patent: May 12, 2020Assignee: University of Southern CaliforniaInventors: Peter S. Conti, Hancheng Cai, Zibo Li, Shuanglong Liu
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Patent number: 10471161Abstract: A thio-selective radioactive labeling agent has the following general formula: *R-L-VS, wherein said *R is a radioisotope, L is a linking group, and VS is a vinylsulfone functional group.Type: GrantFiled: March 8, 2014Date of Patent: November 12, 2019Assignees: University of Southern California, City of HopeInventors: Zibo Li, Peter S. Conti, Lin Li, Zhanhong Wu, Shuanlong Liu, John E. Shively, David Horne
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Patent number: 10434197Abstract: A Diels-Alder adduct of a trans-cyclooctene with a tetrazine is provided, wherein the adduct bears a substituent labeled with a radionuclide. A method of producing a PET or other image of an organ in an animal or human includes forming the Diels-Alder adduct in the animal or human. Trans-cyclooctenes and tetrazines suitable for preparing the adducts are provided.Type: GrantFiled: July 21, 2011Date of Patent: October 8, 2019Assignees: University of Delaware, University of Southern CaliforniaInventors: Joseph M. Fox, Matthew Hassink, Melissa Blackman, Zibo Li, Peter S. Conti, Ramajeyam Selvaraj
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Publication number: 20190247527Abstract: The present invention relates to 18F-labeled compounds suitable for positron emission tomography (PET) imaging. The invention further relates to the use of these compounds for carrying out PET scans, imaging the indoleamine 2,3-dioxygenase, pathway, predicting the responsiveness of a subject with a solid tumor to therapies including immunotherapy such as PD-1/PD-L1 inhibition, and determining whether a solid tumor in a subject contains tumor-infiltrating immune cells.Type: ApplicationFiled: October 20, 2017Publication date: August 15, 2019Inventors: Zibo Li, Zhanhong Wu, Ben Giglio, Stergios Moschos
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Publication number: 20180340001Abstract: The present invention contemplates a method for synthesizing [18F] fluoride complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species for use as imaging agents. The present invention further contemplates kits for making [18F] fluoride complexes suitable for performing radio-labeling reactions to generate [18F] fluorinated species. The present invention further contemplates a method of using [18F] fluoride prosthetic group for targeted tissue and disease imaging.Type: ApplicationFiled: April 19, 2018Publication date: November 29, 2018Inventors: Francois P. Gabbai, Boris Vabre, Kantapat Chansaenpak, Zibo Li, Mengzhe Wang, Hui Wang
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Patent number: 9987380Abstract: A composition useful as a PET and/or fluorescence imaging probe a compound a compound of Formula I, including salts, hydrates and solvates thereof: wherein R1-R7 may be independently selected from hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, X is selected from the group consisting of C and N; and A is selected of hydrogen, halogen, hydroxy, alkoxy, nitro, substituted and unsubstituted amino, alkyl, cycloalkyl, carboxy, carboxylic acids and esters thereof, cyano, haloalkyl, aryl, including phenyl and aminophenyl, and heteroaryl.Type: GrantFiled: July 13, 2012Date of Patent: June 5, 2018Assignee: University of Southern CaliforniaInventors: Zibo Li, Francois P. Gabbai, Peter S. Conti, Todd W. Hudnall, Tzu-Pin Lin, Shuanglong Liu, Chiun-Wei Huang