Abstract: Uniform and location patterned drug release can be achieved via microchannel(s) embedded in a drug dispensing ophthalmic device. At least one reservoir can be encapsulated within the ophthalmic device at a discrete location to hold an amount of a drug. Each reservoir can be covered by an electrode that electrodissolves to release the drug. At least one microchannel having a length and holding at least water is encapsulated in the ophthalmic device between the reservoir and the side of the ophthalmic device facing the eye. After release from the reservoir, the drug spreads through an entirety of the length of the microchannel due to a capillary force inside the microchannel and a diffusion coefficient of the drug in the water. The amount of the drug diffuses from a plurality of locations along the entirety of the length of the microchannel.

Abstract: An under-lid device (ULD), at least a portion of which is coated with a hydrogel comprising hydroxypropyl methylcellulose and/or hyaluronic acid, is described. Methods of using the ULD to treat dry eye, kits for the ULD, and methods of incorporating the tear retention polymers hydroxypropyl methylcellulose or hyaluronic acid into the hydrogel are also described.

Abstract: An apparatus, system, and method of reducing and controlling values of at least one characteristic (e.g., impedance) associated with biopotential-signal sensors is provided. The apparatus, system, and method includes monitoring—based on data from a wearable device that includes a biopotential-signal sensor, a characteristic-stabilizing component, and a characteristic monitor—a characteristic at the sensor-skin interface that impacts the biopotential-signal sensor's ability to sense biopotential signals. In accordance with selecting a biopotential-signal sensitivity need, provide an adjustment (e.g., stimulation) to the characteristic in accordance with a sensitivity-stabilizing mode until the characteristic satisfies the first biopotential-signal sensitivity need. The adjustments may be provided in various methods to achieve desired results.

Abstract: A tiered therapeutic reservoir of an ophthalmic device is described for controlled delivery of two or more therapeutic doses to a patient's eye. An ophthalmic device can include a reservoir having an interior and a metal electrode covering an opening of the reservoir. The interior of the reservoir can hold one or more pharmaceuticals or does of pharmaceuticals (referred to as drugs). The reservoir can hold a first drug and a second drug, with a sacrificial barrier layer positioned between the first drug and the second drug. The metal electrode can electrodissolve upon receiving an electrical signal to release the first drug from the reservoir. The sacrificial barrier layer can be sacrificed after the electrodissolution of the metal electrode to release the second drug from the reservoir. The first drug and the second drug can be released to an eye of a patient in contact with the ophthalmic device.

Abstract: An ophthalmic device can be positioned on a surface of an eye and can modulate an amount of light that can be transmitted therethrough in response to environmental factors and/or release of a therapeutic agent into the eye. The ophthalmic device can include an electronically-mediated medium that can modulate an amount of light transmitted in response to a first electrical signal generated by a signal generator. The ophthalmic device also can include at least one drug reservoir that can release a therapeutic agent to the eye in response to a second electrical signal generated by the signal generator. The signal generator can be encapsulated within the ophthalmic device and in communication with a controller that defines parameters of the electrical signals generated by the signal generator.

Abstract: A wearable device can include a sweat collection unit, and optionally, a sweat stimulation unit. The sweat collection unit includes at least one microfluidics channel to collect sweat from a user, a chamber to hold the sweat, and a loading chamber with sweat collection paper that attracts the sweat through the chamber. A chloride sensing unit located within the chamber includes a gold working electrode and a counter electrode that can determine if enough sweat is in the chamber and, if enough, the chloride concentration of the sweat can be determined based on electrochemical reactions in response to electrical signals applied through the electrodes. A controller of the device can notify a user to trigger the sweat stimulation unit if not enough sweat is in the chamber.

Abstract: The present disclosure relates to non-destructive methods for collecting data from three-dimensional objects. Method include directing one or more interrogating beams of light towards a surface of a three-dimensional object, where the three-dimensional object includes one or more underlying surfaces, and one or more materials having excitonic properties are disposed on the surface of the three-dimensional object; capturing, using an imaging device, optic response of the one or more materials having excitonic properties to the one or more interrogation beams; and computing, using the imaging device, a distance between the one or more underlying surfaces and the one or more materials having excitonic properties, where the optic response of the one or more materials having excitonic properties is a function of the distance between the one or more materials having excitonic properties and the one or more underlying surfaces.

Abstract: Efficient electrochemical reactions can be achieved using a two-electrode system embedded within a silicone hydrogel by using a one-step linear sweep-hold method. A voltage value is initially set to be a voltage that corresponds to a peak current (Vp). An amperometric process is performed at the voltage value. During the amperometric process, the voltage value is corrected as a current shifts.

Abstract: An ophthalmic device including a hydrogel-based material body that can encapsulate a reservoir housing a therapeutic and a metal electrode covering the reservoir. The therapeutic can be delivered into an eye by way of electrodissolution of the metal electrode. The electrodissolution can be enhanced by the presence of chloride ions proximal to the metal electrode, and the ophthalmic device can be engineered to ensure the presence of chloride ions proximal to the metal electrode.

Abstract: a substrate configured to be positioned in the presence of a fluid; a first electrode comprising a conductive film disposed on the substrate; and a second electrode comprising the conductive film disposed on the substrate and spaced from the first electrode. The device may further include a current measurement circuit configured to: apply a voltage between the first electrode and the second electrode, wherein the voltage is in an electrochemical active range of the conductive film such that a portion of the conductive film dissolves into the fluid; and transmit, to a processor, a signal indicating a current measurement of an electrical current flowing through the fluid including the dissolved portion of the conductive film.

Abstract: The present disclosure relates to non-destructive methods for collecting data from three-dimensional objects. Method include directing one or more interrogating beams of light towards a surface of a three-dimensional object, where the three-dimensional object includes one or more underlying surfaces, and one or more materials having excitonic properties are disposed on the surface of the three-dimensional object; capturing, using an imaging device, optic response of the one or more materials having excitonic properties to the one or more interrogation beams; and computing, using the imaging device, a distance between the one or more underlying surfaces and the one or more materials having excitonic properties, where the optic response of the one or more materials having excitonic properties is a function of the distance between the one or more materials having excitonic properties and the one or more underlying surfaces.