Patents by Inventor Zifei Pei

Zifei Pei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND MATERIALS FOR TREATING CANCER
    Publication number: 20220152224
    Abstract: This document relates to methods and materials for treating a mammal having cancer. For example, methods and materials for converting one or more cancer cells present in a mammal with cancer into non-cancerous cells are provided.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 19, 2022
    Inventors: Gong CHEN, Xin WANG, Zifei PEI
  • GENERATING GABAergic NEURONS IN BRAINS
    Publication number: 20210260217
    Abstract: This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic neurons (e.g., neurons resembling medium spiny neurons such as DARPP32-positive GABAergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided.
    Type: Application
    Filed: February 18, 2021
    Publication date: August 26, 2021
    Inventors: Gong Chen, Ziyuan Guo, Zheng Wu, Zifei Pei, Yuchen Chen
  • Generating GABAergic neurons in brains
    Patent number: 10973930
    Abstract: This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic neurons (e.g., neurons resembling medium spiny neurons such as DARPP32-positive GABAergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided.
    Type: Grant
    Filed: February 17, 2017
    Date of Patent: April 13, 2021
    Assignee: The Penn State Research Foundation
    Inventors: Gong Chen, Ziyuan Guo, Zheng Wu, Zifei Pei, Yuchen Chen
  • METHODS AND MATERIALS FOR TREATING BRAIN INJURIES
    Publication number: 20210032300
    Abstract: This document provides methods and materials for treating brain injuries. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide to convert reactive astrocytes within a brain (e.g., cerebral cortex) into functional neurons (e.g., neurons that can be functionally integrated into the brain of a living mammal (e.g., a human)) are provided.
    Type: Application
    Filed: February 1, 2019
    Publication date: February 4, 2021
    Inventors: Gong Chen, Lei Zhang, Ziyuan Guo, Zifei Pei
  • METHODS AND MATERIALS FOR TREATING HUNTINGTON'S DISEASE
    Publication number: 20200405801
    Abstract: This document provides methods and materials for treating a mammal having Huntington's disease. For example, methods and materials for forming GABAergic neurons that are functionally integrated into the brain of a living mammal (e.g., a human) and/or for modifying one or both huntingtin (Htt) genes (or HTT RNAs or HTT polypeptides) present in a mammal with Huntington's disease are provided.
    Type: Application
    Filed: June 17, 2020
    Publication date: December 31, 2020
    Inventors: Gong Chen, Zheng Wu, Ziyuan Guo, Yuchen Chen, Zifei Pei
  • GENERATING GABAergic NEURONS IN BRAINS
    Publication number: 20170239373
    Abstract: This document provides methods and materials for generating GABAergic neurons in brains. For example, methods and materials for using nucleic acid encoding a NeuroD1 polypeptide and nucleic acid encoding a Dlx2 polypeptide to trigger glial cells (e.g., NG2 glial cells or astrocytes) within the brain (e.g., striatum) into forming GABAergic neurons (e.g., neurons resembling medium spiny neurons such as DARPP32-positive GABAergic neurons) that are functionally integrated into the brain of a living mammal (e.g., a human) are provided.
    Type: Application
    Filed: February 17, 2017
    Publication date: August 24, 2017
    Inventors: Gong Chen, Ziyuan Guo, Zheng Wu, Zifei Pei, Yuchen Chen