Abstract: Disclosed is an active inserted gastric tube with an intra-body communication function, including a tube body, a pulse module, an intra-body communication module and a control module. The pulse module is arranged at a front end of the tube body, and is configured to generate a pulse signal. the intra-body communication module is configured to receive the pulse signal generated by the pulse module and transmit the pulse signal to the control module. The control module is configured to analyze the received pulse signal. In this way, the pulse signal is generated by the pulse module, and the gastric tube is inserted into the esophagus through the tube body. The pulse signal is transmitted through a human body to realize an intra-body communication. The control module analyzes the pulse signal transmitted through the human body, so as to identify whether the tube body is inserted into the esophagus or trachea.

Abstract: IgG epitope and applications thereof as a target are provided. The IgG epitope is the CH1 domain of non-B cell-derived IgG, and there is N-glycosylated sialic acid modification at the Asn162 site of the domain. The realization of its antigen functions must depend on the sialylation of the site. The present invention further discloses the applications of the IgG epitope as a drug target in preparing drugs for diagnosis and/or treatment of epithelial tumors. In addition, our studies showed that this antigen depends on the sialylation of Asn162 site as a drug target, and the sialylation of this site must depend on sialyltransferase ST3GAL4, indicating that the enzyme can be used as a drug target for preparing tumor therapeutic drugs. Further, integrin ?4 is co-expressed and co-localized with IgG containing the epitope. IgG can be used as a marker for preparing drugs for the auxiliary detection of epithelial tumors.