Abstract: Provided is a confined migration microfluidic device for cell culture and drug screening, including a chip including a plurality of parallel channels, where each pair of it is connected through a plurality of the confined migration channels; a depth of the confined migration channel is lower than the first channel and second channel; a first/second inlet and a first/second outlet are provided at two ends of the first/second channel, respectively; and a pyramid-like structure for diverging flow to the first channels to ensure evenly distribution. During the usage, cells to be cultured are added into one of the first channel and the second channel, and drugs or cells which can influence confined migration of the target cells are added into the other channel; the inhibitory effect of the drugs or cells on the confined migration will be evaluated, thereby screening/studying effective drugs and cells in relation to the confined migration.

Abstract: A test method based on a test system for five-dimensional space effects of ground surface settlement caused by dual-mode shield construction is provided. First, manufacturing a formation similarity material model; then, laying ground surface monitoring points in longitudinal and transverse direction; installing a shield machine model, and performing shield construction, the shield machine model adopts a double-shield body mode; performing five-dimensional monitoring during shield construction; designing an observation method for ground surface settlement data in step length and time dimension, and acquiring five-dimensional data in combination with three-dimensional scanning; and finally, performing deformation information processing according to the monitored data, so as to realize an acquisition of the five-dimensional data.