Abstract: The invention discloses a method for preparing esomeprazole magnesium trihydrate by crystal transformation, and relates to the technical field of pharmaceutical preparations and crystallization. It includes the following steps of preparing an esomeprazole potassium aqueous solution, preparing a magnesium sulfate heptahydrate aqueous solution, a reactive crystallization process to obtain the esomeprazole magnesium tetrahydrate, and filtering the obtained esomeprazole magnesium tetrahydrate to obtain a sphaerocrystal of esomeprazole magnesium trihydrate. The method for preparing esomeprazole magnesium trihydrate by crystal transformation in the present invention is characterized by using the esomeprazole potassium aqueous solution and the magnesium sulfate aqueous solution for ion exchange to obtain the esomeprazole magnesium tetrahydrate.

Abstract: The provided is a data center-based multi-energy complementary system, including a data center, an energy pile group, a storage battery, an inverter, a solar photovoltaic/thermal (PV/T) panel, a medium-deep borehole heat exchanger (MDBHE), a chiller, a user, an absorption refrigeration unit, a chilled water tank, a supply header, a return header, a waste heat pump unit, a hot water storage tank, a ground source heat pump (GSHP) unit, a cold-hot water tank, a plurality of four-way valves, a plurality of valves, a plurality of cooling towers, a plurality of water circulating pumps, and a plurality of plate heat exchangers. Various devices are connected to form different loops. The provided constructs a hierarchical heat storage system by means of the energy pile group in the shallow geostructure and the MDBHE, and realizes cascaded energy utilization in combination with the solar PV/T panel technology, thereby forming an integrated system.

Abstract: Provided are a display substate and a display device. The display substrate includes a display region and a first peripheral region around at least one side of the display region; where the display substrate includes a first substrate and a second substrate that are oppositely disposed. The first substrate includes a first base and a driving circuit layer on a side of the substrate; wherein the second substrate includes a second base, a first light-shielding layer at a side of the second base and a second light-shielding layer at a side of the first light-shielding layer; where the first light-shielding layer includes a first light-shielding portion in the display region and the first peripheral region, and the first light-shielding portion includes first openings; where the second light-shielding layer is in the first peripheral region, and the second light-shielding layer includes a second light-shielding portion. The display device includes the display substrate.

Abstract: Disclosed are an online meeting interface method and apparatus, a medium, and a computer program product, which relate to the technical field of online meetings. The method includes obtaining a frame background image of the online meeting in a same-frame mode; generating a same-frame picture based on the frame background image and video pictures of participants, the video pictures of different participants being displayed at different positions of the frame background image; and pushing the same-frame picture to clients of the participants. The clients may display the same-frame picture in the online meeting interface.

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

Abstract: The present disclosure describes conversation-based messaging techniques. The techniques comprise generating a thread identifier (ID) corresponding to a new conversation based on receiving a user input indicative of starting the new conversation, wherein the user input is received from a user via a predetermined interface element on a user interface; displaying a window overlaid on the user interface in response to receiving the user input via the predetermined interface element, wherein the window comprises a plurality of representative elements corresponding to a plurality of types of conversation attribute; and creating one or more attributes of the new conversation based at least in part on selecting one or more representative elements among the plurality of representative elements, wherein the creating one or more attributes of the new conversation further comprises associating the one or more attributes with the thread ID of the first conversation.

Abstract: An array substrate and a display panel, which relate to the technical field of flexible displays and are used for solving the problem of the Newton's ring phenomenon due to unequal spacing between transparent layers affects the display effect of the display panel. The array substrate or a display panel include at least two transparent layers stacked in sequence, and a light adjusting layer arranged between at least two adjacent transparent layers, where a product of a refractive index of the light adjusting layer and a thickness of the light adjusting layer is greater than one half of a preset wave train length.

Abstract: Disclosed are an online meeting interface method and apparatus, a medium, and a computer program product, which relate to the technical field of online meetings. The method includes obtaining a frame background image of the online meeting in a same-frame mode; generating a same-frame picture based on the frame background image and video pictures of participants, the video pictures of different participants being displayed at different positions of the frame background image; and pushing the same-frame picture to clients of the participants. The clients may display the same-frame picture in the online meeting interface.

Abstract: The disclosure relates improved self-replicating RNA vectors e.g., for use as a RNA vaccine or therapeutic, and methods of use.

Abstract: The present invention relates to the field of disease treatment. In particular, the present invention provides a gp96 protein and use of a gp96 protein-constructed fusion protein in treating amyotrophic lateral sclerosis. In addition, the present invention further relates to a pharmaceutical composition that can be used for treating one or more of the symptoms of amyotrophic lateral sclerosis, comprising the gp96 protein or the gp96 protein-constructed fusion protein of the present invention.

Abstract: A system for optimizing traffic signal timing using telemetry includes: wirelessly connected devices (WCDs), traffic operations centers (TOCs) controlling one or more traffic signals, and control modules storing and continuously executing control logic in a closed loop. The control logic continuously receives real-time WCD telemetry data and performs real-time processing of the telemetry data to match the telemetry data to physical locations. Processed telemetry data is aggregated to determine WCD trajectories. The system selectively performs time-of-day (TOD), offset, and green split optimizations, and receives the WCD trajectories and outputs of the TOD, offset, and green split optimization within an API. The system generates an optimized signal plan from data from the API, and verifies the optimized signal plan. The optimized signal plan is received by the TOCs and selectively uploaded to the traffic signals.

Abstract: The present invention belongs to the field of nucleotides and mRNA, and specifically relates to modified self-replicating mRNA. A polynucleotide fragment thereof comprises an integrated target fragment and one or more non-structural replicase domains from an ? virus, the integrated target fragment comprising a functional nucleotide analogue; and the functional nucleotide analogue comprises: at least one among pseudouridine, N1-methylpseudouridine, 5-hydroxymethoxycytidine, and N6-methyladenosine.

Abstract: A multi-gate total ionizing dose (TID) radiation-hardened device includes a semiconductor substrate on which a shallow trench isolation (STI) region and a plurality of Fin structures are provided. The STI region is provided between adjacent two Fin structures. A middle portion of a section of the STI region perpendicular to a source-drain direction is hollowed out. A surface of an upper part of each Fin structure not in contact with the STI structure is provided with a gate structure across the Fin structures. A part of the Fin structures in contact with the gate structure is configured as a channel region. A lower part of each Fin structure is covered by the STI region.

Abstract: The invention discloses a method for preparing esomeprazole magnesium trihydrate by crystal transformation, and relates to the technical field of pharmaceutical preparations and crystallization. It includes the following steps of preparing an esomeprazole potassium aqueous solution, preparing a magnesium sulfate heptahydrate aqueous solution, a reactive crystallization process to obtain the esomeprazole magnesium tetrahydrate, and filtering the obtained esomeprazole magnesium tetrahydrate to obtain a sphaerocrystal of esomeprazole magnesium trihydrate. The method for preparing esomeprazole magnesium trihydrate by crystal transformation in the present invention is characterized by using the esomeprazole potassium aqueous solution and the magnesium sulfate aqueous solution for ion exchange to obtain the esomeprazole magnesium tetrahydrate.

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

Abstract: A photoelectric computing unit, a photoelectric computing array and a photoelectric computing method. The photoelectric computing unit includes a semiconductor multifunctional region structure, which includes at least one carrier control region, at least one coupling region, and at least one photon-generated carrier collection region and readout region.

Abstract: The disclosure relates to the method of lyophilizing RNA and mixing with a liquid LNP solution, e.g., to make an RNA vaccine or therapeutic. Included are methods for preparing and administering the vaccine or therapeutic.

Abstract: The disclosure relates to a liposome packaged RNA replicon encoding IL-12. Included are methods for preparing and administering the liposome packaged RNA replicon encoding IL-12.