Abstract: A system for optimizing traffic signal timing using telemetry includes: wirelessly connected devices (WCDs), traffic operations centers (TOCs) controlling one or more traffic signals, and control modules storing and continuously executing control logic in a closed loop. The control logic continuously receives real-time WCD telemetry data and performs real-time processing of the telemetry data to match the telemetry data to physical locations. Processed telemetry data is aggregated to determine WCD trajectories. The system selectively performs time-of-day (TOD), offset, and green split optimizations, and receives the WCD trajectories and outputs of the TOD, offset, and green split optimization within an API. The system generates an optimized signal plan from data from the API, and verifies the optimized signal plan. The optimized signal plan is received by the TOCs and selectively uploaded to the traffic signals.

Abstract: The present invention belongs to the field of nucleotides and mRNA, and specifically relates to modified self-replicating mRNA. A polynucleotide fragment thereof comprises an integrated target fragment and one or more non-structural replicase domains from an ? virus, the integrated target fragment comprising a functional nucleotide analogue; and the functional nucleotide analogue comprises: at least one among pseudouridine, N1-methylpseudouridine, 5-hydroxymethoxycytidine, and N6-methyladenosine.

Abstract: The invention discloses a method for preparing esomeprazole magnesium trihydrate by crystal transformation, and relates to the technical field of pharmaceutical preparations and crystallization. It includes the following steps of preparing an esomeprazole potassium aqueous solution, preparing a magnesium sulfate heptahydrate aqueous solution, a reactive crystallization process to obtain the esomeprazole magnesium tetrahydrate, and filtering the obtained esomeprazole magnesium tetrahydrate to obtain a sphaerocrystal of esomeprazole magnesium trihydrate. The method for preparing esomeprazole magnesium trihydrate by crystal transformation in the present invention is characterized by using the esomeprazole potassium aqueous solution and the magnesium sulfate aqueous solution for ion exchange to obtain the esomeprazole magnesium tetrahydrate.

Abstract: The disclosure provides rocaglate acyl sulfamides (Roc ASFs), compositions and kits comprising same, and methods for their use.

Abstract: A photoelectric computing unit, a photoelectric computing array and a photoelectric computing method. The photoelectric computing unit includes a semiconductor multifunctional region structure, which includes at least one carrier control region, at least one coupling region, and at least one photon-generated carrier collection region and readout region.

Abstract: The disclosure relates to the method of lyophilizing RNA and mixing with a liquid LNP solution, e.g., to make an RNA vaccine or therapeutic. Included are methods for preparing and administering the vaccine or therapeutic.

Abstract: The disclosure relates to a liposome packaged RNA replicon encoding IL-12. Included are methods for preparing and administering the liposome packaged RNA replicon encoding IL-12.

Abstract: A system for optimizing traffic signal timing using telemetry includes: wirelessly connected devices (WCDs), traffic operations centers (TOCs) controlling one or more traffic signals, and control modules storing and continuously executing control logic in a closed loop. The control logic continuously receives real-time WCD telemetry data and performs real-time processing of the telemetry data to match the telemetry data to physical locations. Processed telemetry data is aggregated to determine WCD trajectories. The system selectively performs time-of-day (TOD), offset, and green split optimizations, and receives the WCD trajectories and outputs of the TOD, offset, and green split optimization within an API. The system generates an optimized signal plan from data from the API, and verifies the optimized signal plan. The optimized signal plan is received by the TOCs and selectively uploaded to the traffic signals.

Abstract: Disclosed in the present invention are an ionizable lipid molecule, a preparation method therefor, a composition containing same, an application thereof in the preparation of a vector for delivering a nucleic acid to a cell, and an application thereof in the preparation of a lipid nanoparticle (LNP). By improving the structure of the ionizable lipid molecule and adjusting an LNP component solution, the effect of an mRNA-LNP preparation is improved. The ionizable lipid molecule of the present invention has a structure of formula (I). The ionizable lipid molecule is synthesized with phospholipid, cholesterol, and polyethylene glycol by means of microfluidics to obtain the LNP, and the obtained LNP can improve the translation expression level of a load-mRNA in the cell, improve the effect of the mRNA-LNP preparation, and provide a theoretical basis for theoretical treatment of the personalized mRNA-LNP preparation.

Abstract: Disclosed are a game control method, an electronic device and a computer-readable storage medium. In response to a first operation on an object control in a virtual scene, a virtual object corresponding to the object control is displayed in an object display area in a battle area of the virtual scene, and a skill control is displayed in a control display area where the object control is placed. In response to a second operation on the skill control, an apply range and an indicator of a first target skill corresponding to the skill control are displayed in the battle area, and the virtual object is controlled to apply the first target skill in accordance with the indicator.

Abstract: The present invention discloses a method for identifying travel classification based on smartphone travel surveys. The method takes individual volunteers as the object, GPS information collected by smartphones and instant recall verification features of respondents as the data source. First, travel features, individual features, and family features are determined by GPS data and questionnaire information of volunteers. Then, a training data set is determined by the equal proportion method. Finally, an artificial neural network combined with a particle swarm optimization algorithm is used to detect travel classification from the survey data. The method described in the invention can realize automatic identification of six travel classifications. It is conducive to replace the traditional resident travel survey with the advanced survey method under the environment of big data. At the same time, it provides data foundation for urban management and planning.

Abstract: Disclosed is a negative electrode for a lithium/sodium ion battery and a preparation method therefor, belonging to the field of metal ion battery. The negative electrode includes an electron insulating modification layer and a conventional negative electrode for a lithium/sodium ion battery; the electron insulating modification layer is confinedly coated on the surface of the conventional negative electrode for the lithium/sodium ion battery, forming a porous thin film; and the conventional negative electrode for the lithium/sodium ion battery includes a metal current collector and a powder composite layer of negative electrode, including an active material, a conductive additive, and a binder.

Abstract: Provided herein are compounds useful in the treatment of inflammatory diseases, pharmaceutical compositions comprising the same, and methods of use and preparation thereof. The compounds exhibit inhibitory effects on the expression and secretion of pro-inflammatory cytokines, such as IL-1?, IL-6 and TNF-?.

Abstract: A messaging system may receive a plurality of messages in a conversation maintained by a messaging service. It may be determined that a first message sent from a first messaging application associated with a first user comprises information identifying a second user. The messaging system may receive information indicative of a date associated with the first message. At least one database may store an association among at least the first message, the second user, and the date. The messaging system may send information indicative of the date still being active in the at least one database to a second messaging application associated with the second user.

Abstract: A method of operating a network device is provided. In response to an unplanned reboot, the network device can determine whether an unplanned reboot expedited recovery feature has been enabled on the network device. After determining that the unplanned reboot expedited recovery feature is enabled, the network device can identify a cause of the unplanned reboot. If the cause of the unplanned reboot is from a first set of events, a first bootup sequence can be performed. If the cause of the unplanned reboot is from a second set of events, a second bootup sequence that is expedited relative to the first bootup sequence can be performed.

Abstract: A method of operating a network device is provided. In response to an unplanned reboot, the network device can determine whether an unplanned reboot expedited recovery feature has been enabled on the network device. After determining that the unplanned reboot expedited recovery feature is enabled, the network device can identify a cause of the unplanned reboot. If the cause of the unplanned reboot is from a first set of events, a first bootup sequence can be performed. If the cause of the unplanned reboot is from a second set of events, a second bootup sequence that is expedited relative to the first bootup sequence can be performed.

Abstract: Disclosed are an online meeting interface method and apparatus, a medium, and a computer program product, which relate to the technical field of online meetings. The method includes obtaining a frame background image of the online meeting in a same-frame mode; generating a same-frame picture based on the frame background image and video pictures of participants, the video pictures of different participants being displayed at different positions of the frame background image; and pushing the same-frame picture to clients of the participants. The clients may display the same-frame picture in the online meeting interface.

Abstract: The present disclosure describes conversation-based messaging techniques. The techniques comprise generating a thread identifier (ID) corresponding to a new conversation based on receiving a user input indicative of starting the new conversation, wherein the user input is received from a user via a predetermined interface element on a user interface; displaying a window overlaid on the user interface in response to receiving the user input via the predetermined interface element, wherein the window comprises a plurality of representative elements corresponding to a plurality of types of conversation attribute; and creating one or more attributes of the new conversation based at least in part on selecting one or more representative elements among the plurality of representative elements, wherein the creating one or more attributes of the new conversation further comprises associating the one or more attributes with the thread ID of the first conversation.

Abstract: The disclosure discloses a reconfigurable hardware acceleration method and system for Gaussian pyramid construction and belongs to the field of hardware accelerator design. The system provided by the disclosure includes a static random access memory (SRAM) bank, a first in first out (FIFO) group, a switch network, a shift register array, an adder tree module, a demultiplexer, a reconfigurable PE array, and a Gaussian difference module. In the disclosure, according to the requirements of different scenarios and different tasks for the system, reconfigurable PE array resources can be configured to realize convolution calculations of different scales. The disclosure includes methods of fast and slow dual clock domain design, dynamic edge padding design, and input image partial sum reusing design.

Abstract: A system to process imaging data includes an imaging system configured to capture image data and event data of a scene, compress the image data and the event data, and transmit the compressed image data and compressed event data to a host. The host is operatively coupled to the imaging system, and includes a processor configured to perform object detection on the compressed image data and the compressed event data to identify one or more objects. The processor is also configured to perform object tracking on the one or more objects. The processor is also configured to predict one or more regions of interest for subsequent data capture based on the object detection and the object tracking. The processor is further configured to provide the one or more regions of interest to the imaging system to control capture of additional image data and additional event data by the imaging system.