Abstract: A sacubitril intermediate, a preparation method therefor, and use thereof. A key intermediate N-Boc amino alcohol represented by formula (10) or formula (10-a) can be efficiently prepared. The intermediate can be used to prepare a neutral endopeptidase (NEP) inhibitor or a prodrug thereof, particularly a NEP inhibitor comprising a skeleton of ?-amino-?-biphenyl-?-methylalkanoic acid or ester, such as sacubitril. Also provided are intermediates for preparing formula (10) or formula (10-a).

Abstract: A method for extracting oils from sauces while simultaneously determining fat content, peroxide value, and acid value is disclosed. The method is simple to operate and requires uncomplicated equipment. It features a short testing cycle and high efficiency, and suitable for the extraction of oils from oil-rich emulsified encapsulated sauces (such as salad dressings) with high extraction rates. The determination of peroxide value and acid value is not affected by pretreatment methods, ensuring more representative results. It addresses the challenges of difficult oil separation and extraction from oil-rich emulsified encapsulated sauces and solves significant issues encountered when using acid hydrolysis and alkaline hydrolysis methods to determine peroxide value and acid value. It enables the simultaneous monitoring of three physicochemical indicators (fat content, peroxide value, and acid value).

Abstract: A method for training a knowledge graph alignment model includes selecting first candidate entity pairs from first entity pairs based on a predicted alignment probability of each of the first entity pairs, and calculating an alignment difficulty degree of each of the first candidate entity pairs. The method further includes selecting first target entity pairs from the first candidate entity pairs based on the alignment difficulty degree of each of the first candidate entity pairs, acquiring a labeled alignment result of each of the first target entity pairs, and obtaining a trained knowledge graph alignment model according to the predicted alignment probability and the labeled alignment result of each of the first target entity pairs.

Abstract: Compositions and methods for detecting nucleic acid-protein interactions, or more generally interactions between a nucleic acid and another molecule. A Cas protein (e.g., a catalytically dead Cas13) is fused to a proximity tagging enzyme (e.g., a Pup ligase) and thus brings the proximity tagging enzyme to the proximity of a protein that binds to a nucleic acid, when the Cas protein recognizes the nucleic acid, e.g., through a guide RNA. The proximity tagging enzyme then tags the protein enabling it to be identified as a protein that interacts with the nucleic acid.

Abstract: This disclosure provides a biodegradable antimicrobial material based on polylactic acid oligomer represented by formula 1 as an active ingredient. The disclosure also provides a process for preparing the polylactic acid oligomer and an antimicrobial product prepared therefrom.

Abstract: A multi-level-architecture multi-fiber composite yarn includes a composite yarn having a first anisotropic expansion coefficient in an axial and/or radial direction, and a matrix material included with the yarn, wherein the matrix material has a second anisotropic expansion coefficient that is different from the first anisotropic expansion coefficient in at least one of the axial or radial directions. A method of fabricating a multi-level-architecture multi-fiber composite yarn includes infiltrating a composite yarn having a first anisotropic expansion coefficient in an axial and/or radial directions with a matrix material having a second anisotropic expansion coefficient different from the first anisotropic expansion coefficient in the axial or radial direction.

Abstract: Provided is a bio-based material having an antibacterial effect, comprising a polymer represented by a formula (1) or a mixture of the polymer represented by the formula (1) and polyethylene glycol as an antibacterial active ingredient. The use of the bio-based material is also mentioned. The antibacterial bio-based material has excellent, stable and long-lasting antibacterial activity, and has remarkable antibacterial effects against various bacteria and fungi. The antibacterial bio-based material also has excellent biodegradability and biocompatibility, is derived from bio-based products produced by microbial fermentation, has high safety and is suitable for industrial production and large-scale use.

Abstract: A multi-level-architecture multi-fiber composite yarn includes a composite yarn having a first anisotropic expansion coefficient in an axial and/or radial direction, and a matrix material included with the yarn, wherein the matric material has a second anisotropic expansion coefficient that is different from the first anisotropic expansion coefficient in at least one of the axial or radial directions. A method of fabricating a multi-level-architecture multi-fiber composite yarn includes infiltrating a composite yarn having a first anisotropic expansion coefficient in an axial and/or radial directions with a matrix material having a second anisotropic expansion coefficient different from the first anisotropic expansion coefficient in the axial or radial direction.