Patents by Inventor Zihua Wang
Zihua Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240105351Abstract: A method for measuring drop time of a control rod cluster integrated with a rod position measurement device is provided, wherein the method is used to measure the drop time of each control rod cluster, and includes: Si, monitoring a voltage Ua of coils in Group A to capture a rod cluster drop signal; S2, searching a point (tmax, Vmax) with a maximum drop speed or with a local maximum drop speed; S3, retroactively calculating, from tmax, an end of a time period T4 when the control rod cluster starts to drop; S4, retroactively searching, from a minimum value point of a drop reference signal DROPref, a start of the time period T4 when the drop reference signal DROPref drops from a maximum value to 33% thereof; and S5, determining, from tmax forward, a time point t6 when a drop speed of the control rod cluster is lower than 0.Type: ApplicationFiled: January 14, 2021Publication date: March 28, 2024Applicant: NUCLEAR POWER OPERATIONS RESEARCH INSTITUTE (NPRI)Inventors: Zhengke CHANG, Minghui ZHANG, Yuan HUANG, Ye TIAN, Shaohua XU, Xinxin LIU, Weijian ZHU, Yiming MA, Shengfeng XU, Bo CHAO, Ning TAO, Zihua YANG, Desong LANG, Qichao WANG
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Patent number: 11939630Abstract: Disclosed is a fluorescent PCR method for detecting HLA-B*15:02 allele and a specific primer probe combination. In the present disclosure, a set of primers and probes are designed based on an HLA-B*15:02 specific SNP gene locus by using TaqMan probe technology, combining another set of primers and probes corresponding to the internal reference gene ?-Actin, and a set of primer probe for non-HLA-B*15:02 genes are designed to detect whether a DNA sample contains an HLA-B*15:02 gene and whether a sample is homozygous or heterozygous. Compared with the similar detection methods in the past, the technical scheme in the present disclosure inherits the advantages of high specificity, high throughput, high resolution, low cost, simple and convenient operation, process controllability and the like of the fluorescent PCR, and may detect whether a sample is homozygous or heterozygous.Type: GrantFiled: August 19, 2021Date of Patent: March 26, 2024Assignee: Shaanxi Lifegen Co., Ltd.Inventors: Penggao Dai, Zihua Zhong, Hao Wang, Zhiye Cai, Lei Meng, Le Wang
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Patent number: 11835297Abstract: A heat exchanger includes: tubes stacked in a stacking direction, through which fluid flows; and a tank having a core plate to which each of the tubes is connected. The tank has a first space and a second space separated from each other and arranged in the stacking direction to store fluid. The core plate has insertion holes arranged in the stacking direction, through which the tubes are respectively inserted. The core plate has a boundary portion opposing a boundary between the first space and the second space. The core plate has a rigid portion that overlaps at least one of the insertion holes at a position adjacent to the boundary portion so as to increase a rigidity of the core plate.Type: GrantFiled: June 30, 2021Date of Patent: December 5, 2023Assignee: DENSO CORPORATIONInventor: Zihua Wang
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Publication number: 20230364165Abstract: Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.Type: ApplicationFiled: February 7, 2023Publication date: November 16, 2023Inventors: Hua WANG, Lu ZHANG, Yang ZHOU, Zihua WANG
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Patent number: 11739315Abstract: The present invention, SMASH (Short Multiply Aggregated Sequence Homologies), is a technique designed to pack multiple independent mappings into every read. Specifically, the invention relates to a composition comprising a first mixture of different chimeric genomic nucleic acid fragments, wherein each different fragment in the mixture comprises randomly ligated DNA segments, wherein each DNA segment in the fragment is a nucleic acid molecule at least 27 base pairs in length resulting from random fragmentation of a single genome. The invention also relates to methods for generating said composition and use of said composition to obtain genomic information, for example, copy number variation.Type: GrantFiled: May 3, 2019Date of Patent: August 29, 2023Assignee: COLD SPRING HARBOR LABORATORYInventors: Michael H. Wigler, Dan Levy, Zihua Wang
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Patent number: 11590182Abstract: Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.Type: GrantFiled: September 10, 2019Date of Patent: February 28, 2023Assignee: Ohio State Innovation FoundationInventors: Hua Wang, Lu Zhang, Yang Zhou, Zihua Wang
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Publication number: 20230021752Abstract: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.Type: ApplicationFiled: February 14, 2022Publication date: January 26, 2023Inventors: Ravi Kapur, Mehmet Toner, Zihua Wang, Martin Fuchs
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Patent number: 11261492Abstract: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.Type: GrantFiled: October 7, 2019Date of Patent: March 1, 2022Assignees: The General Hospital Corporation, Verinata Health, Inc., GPB Scientific, LLCInventors: Ravi Kapur, Mehmet Toner, Zihua Wang, Martin Fuchs
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Publication number: 20210325116Abstract: A heat exchanger includes: tubes stacked in a stacking direction, through which fluid flows; and a tank having a core plate to which each of the tubes is connected. The tank has a first space and a second space separated from each other and arranged in the stacking direction to store fluid. The core plate has insertion holes arranged in the stacking direction, through which the tubes are respectively inserted. The core plate has a boundary portion opposing a boundary between the first space and the second space. The core plate has a rigid portion that overlaps at least one of the insertion holes at a position adjacent to the boundary portion so as to increase a rigidity of the core plate.Type: ApplicationFiled: June 30, 2021Publication date: October 21, 2021Applicant: DENSO CORPORATIONInventor: Zihua WANG
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Publication number: 20210178403Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: ApplicationFiled: September 15, 2020Publication date: June 17, 2021Inventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
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Patent number: 10947589Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to amplification by polymerase chain reaction (PCR), generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules having a different tag that have been assigned to the same location on the genome, thereby obtaining genomic copy number information unaffected by amplification dType: GrantFiled: March 7, 2016Date of Patent: March 16, 2021Assignee: COLD SPRING HARBOR LABORATORYInventors: James Hicks, Nicholas Navin, Jennifer Troge, Zihua Wang, Michael Wigler
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Patent number: 10786817Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: GrantFiled: April 27, 2018Date of Patent: September 29, 2020Assignees: The General Hospital Corporation, GPB Scientific, LLCInventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
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Patent number: 10731149Abstract: The present invention, SMASH (Short Multiply Aggregated Sequence Homologies), is a technique designed to pack multiple independent mappings into every read. Specifically, the invention relates to a composition comprising a first mixture of different chimeric genomic nucleic acid fragments, wherein each different fragment in the mixture comprises randomly ligated DNA segments, wherein each DNA segment in the fragment is a nucleic acid molecule at least 27 base pairs in length resulting from random fragmentation of a single genome. The invention also relates to methods for generating said composition and use of said composition to obtain genomic information, for example, copy number variation.Type: GrantFiled: January 30, 2017Date of Patent: August 4, 2020Assignee: Cold Spring Harbor LaboratoryInventors: Michael H. Wigler, Dan Levy, Zihua Wang
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Publication number: 20200147155Abstract: Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.Type: ApplicationFiled: September 10, 2019Publication date: May 14, 2020Inventors: Hua WANG, Lu ZHANG, Yang ZHOU, Zihua WANG
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Publication number: 20200140949Abstract: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.Type: ApplicationFiled: October 7, 2019Publication date: May 7, 2020Inventors: Ravi Kapur, Mehmet Toner, Zihua Wang, Martin Fuchs
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Publication number: 20190360023Abstract: The present invention, SMASH (Short Multiply Aggregated Sequence Homologies), is a technique designed to pack multiple independent mappings into every read. Specifically, the invention relates to a composition comprising a first mixture of different chimeric genomic nucleic acid fragments, wherein each different fragment in the mixture comprises randomly ligated DNA segments, wherein each DNA segment in the fragment is a nucleic acid molecule at least 27 base pairs in length resulting from random fragmentation of a single genome. The invention also relates to methods for generating said composition and use of said composition to obtain genomic information, for example, copy number variation.Type: ApplicationFiled: May 3, 2019Publication date: November 28, 2019Applicant: Cold Spring Harbor LaboratoryInventors: Michael H. Wigler, Dan Levy, Zihua Wang
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Patent number: 10435751Abstract: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.Type: GrantFiled: July 26, 2018Date of Patent: October 8, 2019Assignees: Verinata Health, Inc., GPB Scientific, LLC, The General Hospital CorporationInventors: Ravi Kapur, Mehmet Toner, Zihua Wang, Martin Fuchs
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Publication number: 20190153535Abstract: A method for obtaining from genomic material genomic copy number information unaffected by amplification distortion, comprising obtaining segments of the genomic material, tagging the segments with substantially unique tags to generate tagged nucleic acid molecules, such that each tagged nucleic acid molecule comprises one segment of the genomic material and a tag, subjecting the tagged nucleic acid molecules to polymerase chain reaction (PCR) amplification, generating tag associated sequence reads by sequencing the product of the PCR reaction, assigning each tagged nucleic acid molecule to a location on a genome associated with the genomic material by mapping the subsequence of each tag associated sequence read corresponding to a segment of the genomic material to a location on the genome, and counting the number of tagged nucleic acid molecules assigned to the same location on the genome having a different tag, thereby obtaining genomic copy number information unaffected by amplification distortion.Type: ApplicationFiled: February 7, 2019Publication date: May 23, 2019Applicant: Cold Spring Harbor LaboratoryInventors: James Hicks, Nicholas Navin, Jennifer Troge, Zihua Wang, Michael Wigler
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Publication number: 20190001344Abstract: The invention features devices and methods for the deterministic separation of particles. Exemplary methods include the enrichment of a sample in a desired particle or the alteration of a desired particle in the device. The devices and methods are advantageously employed to enrich for rare cells, e.g., fetal cells, present in a sample, e.g., maternal blood and rare cell components, e.g., fetal cell nuclei. The invention further provides a method for preferentially lysing cells of interest in a sample, e.g., to extract clinical information from a cellular component, e.g., a nucleus, of the cells of interest. In general, the method employs differential lysis between the cells of interest and other cells (e.g., other nucleated cells) in the sample.Type: ApplicationFiled: April 27, 2018Publication date: January 3, 2019Inventors: Lotien Richard Huang, Thomas A. Barber, Bruce L. Carvalho, Ravi Kapur, Paul Vernucci, Mehmet Toner, Zihua Wang
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Publication number: 20180327847Abstract: The present invention relates to methods for detecting, enriching, and analyzing rare cells that are present in the blood, e.g. fetal cells. The invention further features methods of analyzing rare cell(s) to determine the presence of an abnormality, disease or condition in a subject, e.g. a fetus by analyzing a cellular sample from the subject.Type: ApplicationFiled: July 26, 2018Publication date: November 15, 2018Inventors: Ravi Kapur, Mehmet Toner, Zihua Wang, Martin Fuchs