Patents by Inventor Zihua ZHONG

Zihua ZHONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fluorescent PCR method for detecting HLA-B*15:02 allele and specific primer probe combination thereof
    Patent number: 11939630
    Abstract: Disclosed is a fluorescent PCR method for detecting HLA-B*15:02 allele and a specific primer probe combination. In the present disclosure, a set of primers and probes are designed based on an HLA-B*15:02 specific SNP gene locus by using TaqMan probe technology, combining another set of primers and probes corresponding to the internal reference gene ?-Actin, and a set of primer probe for non-HLA-B*15:02 genes are designed to detect whether a DNA sample contains an HLA-B*15:02 gene and whether a sample is homozygous or heterozygous. Compared with the similar detection methods in the past, the technical scheme in the present disclosure inherits the advantages of high specificity, high throughput, high resolution, low cost, simple and convenient operation, process controllability and the like of the fluorescent PCR, and may detect whether a sample is homozygous or heterozygous.
    Type: Grant
    Filed: August 19, 2021
    Date of Patent: March 26, 2024
    Assignee: Shaanxi Lifegen Co., Ltd.
    Inventors: Penggao Dai, Zihua Zhong, Hao Wang, Zhiye Cai, Lei Meng, Le Wang
  • FLUORESCENT PCR METHOD FOR DETECTING HLA-B*15:02 ALLELE AND SPECIFIC PRIMER PROBE COMBINATION THEREOF
    Publication number: 20220177955
    Abstract: Disclosed is a fluorescent PCR method for detecting HLA-B*15:02 allele and a specific primer probe combination. In the present disclosure, a set of primers and probes are designed based on an HLA-B*15:02 specific SNP gene locus by using TaqMan probe technology, combining another set of primers and probes corresponding to the internal reference gene ?-Actin, and a set of primer probe for non-HLA-B*15:02 genes are designed to detect whether a DNA sample contains an HLA-B*15:02 gene and whether a sample is homozygous or heterozygous. Compared with the similar detection methods in the past, the technical scheme in the present disclosure inherits the advantages of high specificity, high throughput, high resolution, low cost, simple and convenient operation, process controllability and the like of the fluorescent PCR, and may detect whether a sample is homozygous or heterozygous.
    Type: Application
    Filed: August 19, 2021
    Publication date: June 9, 2022
    Applicant: Shaanxi Lifegen Co., Ltd.
    Inventors: Penggao DAI, Zihua ZHONG, Hao WANG, Zhiye CAI, Lei MENG, Le WANG