Abstract: An initial gather of blended seismic signals induced in a common seismic receiver by a plurality of actual sources grouped in actual source groups is provided. Each actual source group has a linear source geometry that is the same for each actual source group. The plurality of sources in each actual source group is fired according to a pre-selected firing sequence that is the same for each actual source group. Actual shot records are created from the blended signals, and fictive shot records are created of seismic signals for fictive source groups that each have the same source geometry as the actual source groups, by interpolation of the actual shot records. Single source shot records of single source signals are separated by discrete deconvolution of the actual shot records and the fictive shot records. The output includes a seismic gather comprising a plurality of the single source shot records.

Abstract: Simultaneous sources are separated with a deblending method wherein the fullband data deblended on a source-by-source basis. The fullband data is first decomposed into multiple subbands, and then a non-equispaced subband Radon transform is used to transform the decomposed data into the Radon domain. The deblending process is solved subband by subband by minimising a nonlinear objective function. The solution of the nonlinear objective function is found using a multi-step procedure.

Abstract: Simultaneous sources are separated with a deblending method wherein the fullband data deblended on a source-by-source basis. The fullband data is first decomposed into multiple subbands, and then a non-equispaced subband Radon transform is used to transform the decomposed data into the Radon domain. The deblending process is solved subband by subband by minimising a nonlinear objective function. The solution of the nonlinear objective function is found using a multi-step procedure.

Abstract: An initial gather of blended seismic signals induced in a common seismic receiver by a plurality of actual sources grouped in actual source groups is provided. Each actual source group has a linear source geometry that is the same for each actual source group. The plurality of sources in each actual source group is fired according to a pre-selected firing sequence that is the same for each actual source group. Actual shot records are created from the blended signals, and fictive shot records are created of seismic signals for fictive source groups that each have the same source geometry as the actual source groups, by interpolation of the actual shot records. Single source shot records of single source signals are separated by discrete deconvolution of the actual shot records and the fictive shot records. The output includes a seismic gather comprising a plurality of the single source shot records.

Abstract: Presently disclosed are methods of treating cancer comprising administering a MEK inhibitor in combination with a proteasome inhibitor. In some embodiment, the cancer is a solid tumor. In some instances, the cancer has at least one mutation chosen from a NF1, RAS (including N-, K-, and H-RAS), RAF (including A-, B-, and C-RAF), and MEK (including MEK1 and MEK2) mutation. In some embodiments, the cancer is resistant to treatment with at least one of a proteasome inhibitor or a MEK inhibitor. In some embodiments, the combination therapy produces a synergistic effect.