Patents by Inventor Zijing Zeng
Zijing Zeng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20200367760Abstract: Methods and devices for obtaining a blood pressure measurement of a subject measure a transit time of a blood pulse of the subject. A method includes sensing, with a pulse ejection sensor of a wrist-worn device, ejection of blood from the left ventricle. Arrival of a resulting blood pressure pulse at the wrist is sensed via a pulse arrival sensor of the wrist-worn device. A transit time of the blood pressure pulse from the left ventricle to the wrist is determined. A relative blood pressure value of the subject is determined based on the transit time. A reference absolute blood pressure value associated with the relative blood pressure value is received. An absolute blood pressure value for the relative blood pressure value is determined based on the reference absolute blood pressure value and the relative blood pressure value.Type: ApplicationFiled: August 7, 2020Publication date: November 26, 2020Inventors: Erno H. Klaassen, Wren Nancy Dougherty, Richard C. Kimoto, Ravi K. Narasimhan, Thomas J. Sullivan, Stephen J. Waydo, Todd K. Whitehurst, Santiago Quijano, Derek Park-Shing Young, Zijing Zeng
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Patent number: 10786610Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: GrantFiled: August 10, 2018Date of Patent: September 29, 2020Assignee: TC1 LLCInventor: Zijing Zeng
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Patent number: 10779738Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.Type: GrantFiled: August 18, 2017Date of Patent: September 22, 2020Inventors: Thomas J. Sullivan, Wren Nancy Dougherty, Richard C. Kimoto, Erno Klaassen, Ravi Narasimhan, Stephen J. Waydo, Todd K. Whitehurst, Derek Park-Shing Young, Santiago Quijano, Zijing Zeng
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Patent number: 10772512Abstract: The present invention provides non-invasive devices, methods, and systems for determining a pressure of blood within a cardiovascular system of a user, the cardiovascular system including a heart and the user having a wrist covered by skin. More particularly, the present invention discloses a variety of wrist-worn devices having a variety of sensors configured to non-invasively engage the skin on the wrist of the user for sensing a variety of user signals from the cardiovascular system of the user. Generally, approaches disclosed herein may passively track blood pressure values without any interaction required on the part of the user or may allow for on demand or point measurements of blood pressure values by having a user actively interact with the sensors of the wrist-worn device.Type: GrantFiled: August 18, 2017Date of Patent: September 15, 2020Inventors: Erno H. Klaassen, Wren Nancy Dougherty, Richard C. Kimoto, Ravi Narasimhan, Thomas J. Sullivan, Stephen J. Waydo, Todd K. Whitehurst, Santiago Quijano, Derek Park-Shing Young, Zijing Zeng
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Patent number: 10765789Abstract: An impeller for a pump is disclosed herein. The impeller can include a hub having a fixed end and a free end. The impeller can also have a plurality of blades supported by the hub. Each blade can have a fixed end coupled to the hub and a free end. The impeller can have a stored configuration and a deployed configuration, the blades in the deployed configuration extending away from the hub, and the blades in the stored configuration being compressed against the hub.Type: GrantFiled: July 3, 2018Date of Patent: September 8, 2020Assignee: TC1 LLCInventors: Zijing Zeng, Phyllis Yuen, Michael R. Butler
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Patent number: 10702171Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.Type: GrantFiled: September 8, 2015Date of Patent: July 7, 2020Inventors: Ravi Narasimhan, Zijing Zeng, Richard C. Kimoto, Erno Klaassen, Thomas J. Sullivan, Derek Park-Shing Young, Todd K. Whitehurst
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Patent number: 10646121Abstract: The present invention generally relates to the measuring and monitoring of blood pressure. More specifically, embodiments may apply the theory of applanation tonometry for the measurement of blood pressure. Some embodiments provide a method for measuring mean arterial pressure. Some embodiments provide a device that may be worn by a user that may non-invasively measure and monitor blood pressure of a user. In some embodiments, the invention generally relates to sensor arrays for use with a wrist-worn device to measure blood pressure. Embodiments of the sensor array designs described may be configured to improve resolution by decoupling nodes of the sensor array.Type: GrantFiled: September 23, 2016Date of Patent: May 12, 2020Assignee: Apple Inc.Inventors: Ravi K. Narasimhan, Zijing Zeng, Zhipeng Zhang
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Patent number: 10525178Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: GrantFiled: August 9, 2017Date of Patent: January 7, 2020Assignee: TC1 LLCInventor: Zijing Zeng
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Patent number: 10517489Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device includes an accelerometer, a photo-lethysmogram (PPG) or a pulse pressure sensor, and a controller. The PPG or the pulse pressure sensor coupled to the wrist-worn device for detecting an arrival of a blood pressure pulse at the user's wrist. The controller is configured to process output signals from the accelerometer to detect when the blood pressure pulse is propagated from the left ventricle of the user's heart, process a signal from the PPG or the pulse pressure sensor to detect when the blood pressure pulse arrives at the wrist, calculate a pulse transit time (PTT) for propagation of the blood pressure pulse from the left ventricle to the wrist, and generate one or more blood pressure values for the user based on the PTT.Type: GrantFiled: September 8, 2015Date of Patent: December 31, 2019Inventors: Ravi Narasimhan, Richard C. Kimoto, Thomas J. Sullivan, Todd K. Whitehurst, Derek Park-shing Young, Zijing Zeng, Erno Klaassen
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Publication number: 20180344911Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: ApplicationFiled: August 10, 2018Publication date: December 6, 2018Inventor: Zijing Zeng
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Publication number: 20180311423Abstract: An impeller for a pump is disclosed herein. The impeller can include a hub having a fixed end and a free end. The impeller can also have a plurality of blades supported by the hub. Each blade can have a fixed end coupled to the hub and a free end. The impeller can have a stored configuration and a deployed configuration, the blades in the deployed configuration extending away from the hub, and the blades in the stored configuration being compressed against the hub.Type: ApplicationFiled: July 3, 2018Publication date: November 1, 2018Inventors: Zijing Zeng, Phyllis Yuen, Michael R. Butler
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Patent number: 10071192Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: GrantFiled: March 14, 2017Date of Patent: September 11, 2018Assignee: TC1 LLPInventor: Zijing Zeng
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Patent number: 10039872Abstract: An impeller for a pump is disclosed herein. The impeller can include a hub having a fixed end and a free end. The impeller can also have a plurality of blades supported by the hub. Each blade can have a fixed end coupled to the hub and a free end. The impeller can have a stored configuration and a deployed configuration, the blades in the deployed configuration extending away from the hub, and the blades in the stored configuration being compressed against the hub.Type: GrantFiled: May 8, 2017Date of Patent: August 7, 2018Assignee: TC1 LLCInventors: Zijing Zeng, Phyllis Yuen, Michael R. Butler
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Publication number: 20170360306Abstract: The present invention generally relates to blood pressure monitoring. In some embodiments, methods and devices of measuring a mean arterial pressure are provided and/or monitoring blood pressure changes. A wrist-worn device may include a plurality of sensors backed by a plurality of actuators. Subsets of the plurality of sensors may be selectively actuateable against a wrist of a user using one or more of the plurality of actuators. A preferred sensor and location may be identified based on pressure signals received from each of the sensors. In some embodiments, devices may use a fluid bladder coupled with piezoelectric film sensors. A fluid bladder pressure sensor may be used to calibrate the piezoelectric film signal to provide a static and dynamic pressure reading. In yet another embodiment, a mean arterial pressure may be calculated by processing a swept pressure signal obtained as a sensor is swept through different heights.Type: ApplicationFiled: September 8, 2015Publication date: December 21, 2017Applicant: APPLE INC.Inventors: Ravi Narasimhan, Zijing Zeng, Richard C. Kimoto, Erno Klaassen, Thomas J. Sullivan, Derek Park-Shing Young, Todd K. Whitehurst
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Publication number: 20170340219Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device include a wrist-worn elongate band, at least four EKG or ICG electrodes coupled to the wrist-worn device for detecting a ventricular ejection of a heart, a photo-plethysmogram (PPG) sensor coupled to the wrist-worn device for detecting arrival of a blood pressure pulse at the user's wrist, and a controller configured to calculate a pulse transit time (PTT) for the blood pressure pulse. The controller calculates one or more blood pressure values for the user based on the PTT.Type: ApplicationFiled: August 18, 2017Publication date: November 30, 2017Inventors: Thomas J. Sullivan, Wren Nancy Dougherty, Richard C. Kimoto, Erno Klaassen, Ravi Narasimhan, Stephen J. Waydo, Todd K. Whitehurst, Derek Park-Shing Young, Santiago Quijano, Zijing Zeng
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Publication number: 20170340209Abstract: The present invention provides non-invasive devices, methods, and systems for determining a pressure of blood within a cardiovascular system of a user, the cardiovascular system including a heart and the user having a wrist covered by skin. More particularly, the present invention discloses a variety of wrist-worn devices having a variety of sensors configured to non-invasively engage the skin on the wrist of the user for sensing a variety of user signals from the cardiovascular system of the user. Generally, approaches disclosed herein may passively track blood pressure values without any interaction required on the part of the user or may allow for on demand or point measurements of blood pressure values by having a user actively interact with the sensors of the wrist-worn device.Type: ApplicationFiled: August 18, 2017Publication date: November 30, 2017Inventors: Erno H. Klaassen, Wren Nancy Dougherty, Richard C. Kimoto, Ravi Narasimhan, Thomas J. Sullivan, Stephen J. Waydo, Todd K. Whitehurst, Santiago Quijano, Derek Park-Shing Young, Zijing Zeng
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Publication number: 20170333608Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: ApplicationFiled: August 9, 2017Publication date: November 23, 2017Inventor: Zijing Zeng
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Publication number: 20170296722Abstract: A catheter pump assembly is provided that includes a proximal a distal portion, a catheter body, an impeller, and a flow modifying structure. The catheter body has a lumen that extends along a longitudinal axis between the proximal and distal portions. The impeller is disposed at the distal portion. The impeller includes a blade with a trailing edge. The flow modifying structure is disposed downstream of the impeller. The flow modifying structure has a plurality of blades having a leading edge substantially parallel to and in close proximity to the trailing edge of the blade of the impeller and an expanse extending downstream from the leading edge. In some embodiments, the expanse has a first region with higher curvature and a second region with lower curvature. The first region is between the leading edge and the second region.Type: ApplicationFiled: March 14, 2017Publication date: October 19, 2017Inventor: Zijing Zeng
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Publication number: 20170293727Abstract: In some implementations, a user device can assist a user with intelligent blood pressure monitoring. For example, the user device can present notifications and/or reminders that prompt the user to take blood pressure measurements at a prescribed time or according to a prescribed schedule. The user device can automatically determine that the user should or should not take a blood pressure measurement based on the user's context and suggest an alternative time for taking the blood pressure measurement. For example, the user's context can include the user's physical and/or psychological state inferred based on sensor data, application data, and/or other detectable information. In some implementations, the user device can automatically monitor the user's blood pressure and take blood pressure measurements based on user context triggers.Type: ApplicationFiled: April 8, 2016Publication date: October 12, 2017Inventors: Erno H. KLAASSEN, Thomas J. SULLIVAN, Stuart L. GALLANT, Michael O'REILLY, Zijing ZENG, Gracee AGRAWAL
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Publication number: 20170281024Abstract: Wrist-worn devices and related methods measure a pulse transit time non-invasively and calculate a blood pressure value using the pulse transit time. A wrist-worn device includes an accelerometer, a photo-plethysmogram (PPG) or a pulse pressure sensor, and a controller. The PPG or the pulse pressure sensor coupled to the wrist-worn device for detecting an arrival of a blood pressure pulse at the user's wrist. The controller is configured to process output signals from the accelerometer to detect when the blood pressure pulse is propagated from the left ventricle of the user's heart, process a signal from the PPG or the pulse pressure sensor to detect when the blood pressure pulse arrives at the wrist, calculate a pulse transit time (PTT) for propagation of the blood pressure pulse from the left ventricle to the wrist, and generate one or more blood pressure values for the user based on the PTT.Type: ApplicationFiled: September 8, 2015Publication date: October 5, 2017Inventors: Ravi Narasimhan, Richard C. Kimoto, Thomas J. Sullivan, Todd K. Whitehurst, Derek Park-shing Young, Zijing Zeng, Erno Klaassen