Patents by Inventor Ziling Huo
Ziling Huo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8217943Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data, accessing data of at least one template, and displaying the cellular analysis result data and the data of at least one template by overlaying the cellular analysis result data and the data of the at least one template, wherein the cellular analysis result data is displayed using different display attributes from the displayed data of the at least one template.Type: GrantFiled: April 21, 2006Date of Patent: July 10, 2012Assignee: Beckman Coulter, Inc.Inventors: Cheng Qian, Ziling Huo, Patricio J. Vidal
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Patent number: 7457709Abstract: Systems and methods consistent with embodiments of the present invention provide a method for the measurement and analysis of particle counts in flow cytometry and hematology instruments. In some methods for the measurement and analysis of particle counts, a corrected histogram of particle distributions is calculated and used to obtain an accurate count of particles and an accurate measurement of other particle parameters.Type: GrantFiled: December 20, 2005Date of Patent: November 25, 2008Assignee: Beckman Coulter, Inc.Inventors: Shuliang Zhang, Min Zheng, Dongqing Lin, Ziling Huo
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Patent number: 7361512Abstract: A method of producing low hemoglobin concentration cell percentage (LHCC %) and the method of use for detection of iron deficiency have been disclosed. LHCC % is a sigmoid function of mean cell hemoglobin concentration (MCHC), which correlates linearly with hypochromic red cell percentage.Type: GrantFiled: January 19, 2007Date of Patent: April 22, 2008Assignee: Beckman Coulter, Inc.Inventors: Cheng Qian, Ziling Huo, Ramon Simon-Lopez
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Publication number: 20070247463Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data, accessing data of at least one template, and displaying the cellular analysis result data and the data of at least one template by overlaying the cellular analysis result data and the data of the at least one template, wherein the cellular analysis result data is displayed using different display attributes from the displayed data of the at least one template.Type: ApplicationFiled: April 21, 2006Publication date: October 25, 2007Applicant: Beckman Coulter, Inc.Inventors: Cheng Qian, Ziling Huo, Patricio Vidal
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Publication number: 20070248943Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for displaying cellular analysis result data including accessing cellular analysis result data; determining frequency information of a plurality of cell populations from the cellular analysis result data; associating frequency information of each of the plurality of cell populations with a surface elevation point; and displaying an interactive surface plot of the associated frequency information and the surface elevation points.Type: ApplicationFiled: April 21, 2006Publication date: October 25, 2007Applicant: Beckman Coulter, Inc.Inventors: Ralph Taylor, Ziling Huo, Patricio Vidal
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Publication number: 20070250548Abstract: In accordance with the principles of the invention, methods, systems, and computer-readable mediums are provided for processing image data representing cellular analysis result data including accessing image data; generating an intensity histogram based on the image data; transforming the intensity histogram into a stepped image; performing normalized cross-correlation between the stepped image and a reference image to measure similarity; and determining an abnormality based on the measured similarity.Type: ApplicationFiled: April 21, 2006Publication date: October 25, 2007Applicant: Beckman Coulter, Inc.Inventors: Ziling Huo, Xi Li, Phaisit Chewputtanagul
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Publication number: 20070172955Abstract: A method of producing low hemoglobin concentration cell percentage (LHCC %) and the method of use for detection of iron deficiency have been disclosed. LHCC % is a sigmoid function of mean cell hemoglobin concentration (MCHC), which correlates linearly with hypochromic red cell percentage.Type: ApplicationFiled: January 19, 2007Publication date: July 26, 2007Applicant: BECKMAN COULTER, INC.Inventors: Cheng Qian, Ziling Huo, Ramon Simon-Lopez
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Publication number: 20070143033Abstract: Systems and methods consistent with embodiments of the present invention provide a method for the measurement and analysis of particle counts in flow cytometry and hematology instruments. In some methods for the measurement and analysis of particle counts, a corrected histogram of particle distributions is calculated and used to obtain an accurate count of particles and an accurate measurement of other particle parameters.Type: ApplicationFiled: December 20, 2005Publication date: June 21, 2007Applicant: Beckman Coulter, Inc.Inventors: Shuliang Zhang, Min Zheng, Dongqing Lin, Ziling Huo
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Patent number: 7208319Abstract: Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, DC impedance, and medium angle light scatter measurements; by axial light loss, low angle light scatter, and medium angle light scatter measurements; or by axial light loss, DC impedance, low angle light scatter, and medium angle light scatter measurements; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.Type: GrantFiled: January 24, 2006Date of Patent: April 24, 2007Assignee: Beckman Coulter, Inc.Inventors: Lidice L. Lopez, Carlos A. Perez, Mark A. Wells, Diana B. Careaga, Ziling Huo, Cheng Qian, Nancy J. Torke
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Publication number: 20070054404Abstract: A method of measuring a hemoglobin parameter of a test sample of blood comprises diluting and lysing a test sample. Then, a temperature corresponding to the test sample is obtained. The diluted and lysed test sample is then delivered to a cuvette, and a spectrophotometer determines the absorbance and/or transmittance of the sample in the cuvette. With the absorbance and/or transmittance of the test sample, a first measurement of the hemoglobin parameter of the test sample is obtained. After a first measurement of the hemoglobin parameter is obtained, a processor determines a corrected measurement of the hemoglobin parameter of the test sample. The corrected measurement is a function of the measured temperature that corresponds to the test sample and the first measurement of the hemoglobin parameter. The method of measuring a hemoglobin parameter is valid over a range of test sample temperatures.Type: ApplicationFiled: September 8, 2005Publication date: March 8, 2007Applicant: Beckman Coulter, Inc.Inventors: Ziling Huo, William Li, Cheng Qian
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Publication number: 20060160229Abstract: Methods are provided for measurement of nucleated red blood cells in a blood sample. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, DC impedance, and medium angle light scatter measurements; by axial light loss, low angle light scatter, and medium angle light scatter measurements; or by axial light loss, DC impedance, low angle light scatter, and medium angle light scatter measurements; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.Type: ApplicationFiled: January 24, 2006Publication date: July 20, 2006Applicant: Beckman Coulter, Inc.Inventors: Lidice Lopez, Carlos Perez, Mark Wells, Diana Careaga, Ziling Huo, Cheng Qian, Nancy Torke
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Patent number: 7008792Abstract: Methods are provided for measurement of nucleated red blood cells. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, low angle light scatter and DC impedance measurements, or two selected measurements thereof; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.Type: GrantFiled: February 1, 2005Date of Patent: March 7, 2006Assignee: Beckman Coulter, Inc.Inventors: Lidice L. Lopez, Carlos A. Perez, Mark A. Wells, Diana B. Careaga, Ziling Huo, Cheng Qian
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Publication number: 20050176152Abstract: Methods are provided for measurement of nucleated red blood cells. The methods include exposing a blood cell sample to a reagent system to lyse mature red blood cells, subsequently analyzing nucleated red blood cells in a flow cell by axial light loss, low angle light scatter and DC impedance measurements, or two selected measurements thereof; and then differentiating nucleated red blood cells from other cell types by using measured signals and/or functions thereof.Type: ApplicationFiled: February 1, 2005Publication date: August 11, 2005Applicant: Beckman Coulter, Inc.Inventors: Lidice Lopez, Carlos Perez, Mark Wells, Diana Careaga, Ziling Huo, Cheng Qian
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Patent number: 6472215Abstract: A method of analyzing nucleated red blood cells (NRBCs) in a blood sample and further enumerating NRBCs is disclosed. The method includes lysing a first aliquot and a second aliquot of a blood sample separately with a first lysing reagent system and a second lysing reagent system; measuring the first sample mixture in a flow cell by DC, RF, and light scatter measurements; measuring cell distributions and counting remaining blood cells in the second sample mixture by DC impedance measurements in a non-focused flow aperture; analyzing blood cell distribution patterns obtained from measuring the first sample mixture and from measuring the second sample mixture respectively; and further performing a combined analysis to differentiate NRBCs from other cell types and determine numbers of NRBCs in the blood sample.Type: GrantFiled: July 27, 2001Date of Patent: October 29, 2002Assignee: Coulter International Corp.Inventors: Ziling Huo, Jaesang Park, Wei Yao, Shuliang Zhang, Min Zheng