Abstract: The disclosure belongs to the technical field of medicine. Provided are a CD97 and GSDME interaction inhibitor having anti-tumor activity and an application thereof. A compound screened in the disclosure enhances the susceptibility of NK cells to kill tumor cells by inhibiting the interaction between GSDME and CD97 in tumor cells, so as to induce an immune anti-tumor effect. Moreover, the compound enhances the susceptibility of tumor cells to pyroptosis by blocking the protective effect of CD97 on cleavage of GSDME proteins. Therefore, the compound can be used for treating GSDME and CD97 double-positive malignant tumors, and combined chemotherapy, immunotherapy, etc., to enhance the susceptibility of malignant tumors to chemotherapy and immunotherapy, prolonging the overall survival period of patients with malignant tumors. Specifically provided is a compound having a structure set forth in formula (I), a pharmaceutically acceptable salt, a solvent compound or a deuterated compound thereof.

Abstract: A fault detection method, apparatus, and system, and a vehicle, which relates to the field of vehicle control technology. The method includes: acquiring a first signal output by the valve core detection sensor and a second signal output by the draw-wire encoder on each of the plurality of support legs; and determining whether the draw-wire encoder provided on each support leg has a fault according to the first signal, and the second signal output by the draw-wire encoder of each support leg. For the fault detection method, apparatus and system, and the vehicle, it can be used for the solution of detecting whether the draw-wire encoder on the work machine is damaged in real-time, so as to improve the reliability and security of the device.

Abstract: The present disclosure provides modified cell(s), i.e., immune cell(s) or precursor cell(s) thereof, wherein the cell(s) are engineered to express: (a) a first chimeric antigen receptor (CAR) having affinity for CD19, and (b) a second CAR having affinity for a tumor antigen, wherein the tumor antigen is not CD19. Also provided are methods and uses of the modified cells, e.g., for treating at least one sign and/or symptom of cancer in a subject. The modified cells expand in the peripheral blood of the subject. Related nucleic acids, vectors, and pharmaceutical compositions are also provided.

Abstract: A machine tool rapid compensation system includes: a trigger acquisition module, a laser interferometry measurement module, a data analysis and compensation module, and a communication module. The trigger acquisition module receives a trigger acquisition instruction, converts an encoder position value into a pulse value, transmits the pulse value to the laser interferometry measurement module, retrieves parameter information and compensation point information of a machine tool from a numerical control system, and generates a machine tool operation code and a measurement preparation signal. The laser interferometry measurement module receives the measurement preparation signal and the pulse value to obtain error data, environmental data, and expansion compensation values.

Abstract: This specification relates to an apparatus which stores a machine-learned model including a first neural network block including multiple convolutional neural network layers, a second neural network block including at least one dilated convolutional neural network layer, and a linear transformation block. The apparatus is configured to receive input data representing in-phase and quadrature signals of an input signal that is to be amplified by a power amplifier, to process the received input data using the first neural network block of the machine learned model to generate a first neural network block output, to process the received input data using the second neural network block of the machine learned model to generate a second neural network block output, and to combine, using the linear transformation block, the first neural network block output and the second neural network block output to generate a pre-distorted signal for amplification by the power amplifier.

Abstract: A computer implemented method for recognizing an answer sheet includes the steps of: reading a filled answer sheet comprising at least one set of graphical codes; locating each set of graphical codes in the answer sheet; a set of graphical codes comprising one grid or two grids, wherein for each set of graphical codes, if the function mark of the first grid is filled, two sets or four sets of 8-digit binary codes are obtained according to the filling state of each of the filling areas in each grid of the set of graphical codes; and recognizing the corresponding characters according to the encoding format determined by the encoding format mark. If the function mark in the first grid is un-filled, the filling states of the eight icons of the encoding format mark are converted to the third set of binary codes for character recognition.

Abstract: Methods, apparatuses, systems, and computer program products are disclosed for outputting a contextually relevant development unit performance insight interface component in a project management and collaboration system. In an example embodiment, an apparatus detects an insight interface component request, accesses past development unit performance metrics data, determines a suggested development unit performance target, determines a selected development unit commitment, determines a visual emphasis element for the selected development unit commitment, wherein the visual emphasis element is configured to visually compare the selected development unit commitment to the suggested development unit performance target, generates a development unit performance summary insight interface component comprising the visual emphasis element, and outputs the development unit performance summary insight interface component for rendering to a project management user interface.

Abstract: A computer implemented method for recognizing an answer sheet includes the steps of: reading a filled answer sheet comprising at least one set of graphical codes; locating each set of graphical codes in the answer sheet; a set of graphical codes comprising one grid or two grids, wherein for each set of graphical codes, if the function mark of the first grid is filled, two sets or four sets of 8-digit binary codes are obtained according to the filling state of each of the filling areas in each grid of the set of graphical codes; and recognizing the corresponding characters according to the encoding format determined by the encoding format mark. If the function mark in the first grid is un-filled, the filling states of the eight icons of the encoding format mark are converted to the third set of binary codes for character recognition.

Abstract: A loudspeaker system includes a loudspeaker base and a loudspeaker peripheral that is independent of the loudspeaker base. The loudspeaker peripheral is shaped as a role figure. The loudspeaker base and the loudspeaker peripheral connect through a contact connection or a non-contact connection, and provide personalized voice data corresponding to the role figure when connected.

Abstract: A method for preparing an accelerator for sprayed mortar/concrete is provided. The accelerator includes an organic component, inorganic component aluminum sulfate, an initiator, and a reductant. The organic component in the form of a polymer monomer is added to concrete and polymerized into a polymer network structure in the presence of the initiator and the reductant; and the inorganic component aluminum sulfate promotes rapid hydration of the concrete to form an inorganic network structure. Such organic-inorganic interpenetrating network thickens a cement-based material rapidly to achieve strong adhesion, fast-setting and hardening properties and effectively reduces resilience of the sprayed mortar/concrete. The accelerator prepared by the method is well compatible with all sorts of cement, efficient and environmentally friendly.

Abstract: Methods, apparatuses, systems, and computer program products are disclosed for outputting a contextually relevant development unit performance insight interface component in a project management and collaboration system. In an example embodiment, an apparatus detects an insight interface component request, accesses past development unit performance metrics data, determines a suggested development unit performance target, determines a selected development unit commitment, determines a visual emphasis element for the selected development unit commitment, wherein the visual emphasis element is configured to visually compare the selected development unit commitment to the suggested development unit performance target, generates a development unit performance summary insight interface component comprising the visual emphasis element, and outputs the development unit performance summary insight interface component for rendering to a project management user interface.

Abstract: A method for preparing an accelerator for sprayed mortar/concrete is provided. The accelerator includes an organic component, inorganic component aluminum sulfate, an initiator, and a reductant. The organic component in the form of a polymer monomer is added to concrete and polymerized into a polymer network structure in the presence of the initiator and the reductant; and the inorganic component aluminum sulfate promotes rapid hydration of the concrete to form an inorganic network structure. Such organic-inorganic interpenetrating network thickens a cement-based material rapidly to achieve strong adhesion, fast-setting and hardening properties and effectively reduces resilience of the sprayed mortar/concrete. The accelerator prepared by the method is well compatible with all sorts of cement, efficient and environmentally friendly.

Abstract: A method for preparing comb structure temperature/pH-responsive polycarboxylic acid by end-group functionalization adopts temperature/pH-responsive monomer, unsaturated halogenated hydrocarbon, small monomer of carboxylic acid and other raw materials to prepare polycarboxylic acid material via self-polymerization, substitution and copolymerization. Temperature/pH-responsive monomers are first self-polymerized to obtain temperature/pH-responsive polymer chain with end-group functionalization, and then substitution with unsaturated halogenated hydrocarbons is conducted to obtain temperature/pH-responsive macromonomers with end-group functionalization, finally the obtained product is copolymerized with small carboxylic acid monomers to prepare comb structure polymer with polycarboxylic acid main chain and temperature/pH-responsive side chain.

Abstract: A loudspeaker system includes a loudspeaker base and a loudspeaker peripheral that is independent of the loudspeaker base. The loudspeaker peripheral is shaped as a role figure. The loudspeaker base and the loudspeaker peripheral connect through a contact connection or a non-contact connection, and provide personalized voice data corresponding to the role figure when connected.

Abstract: A loudspeaker system includes a loudspeaker base and a loudspeaker peripheral that is independent of the loudspeaker base. The loudspeaker peripheral is shaped as a role figure. The loudspeaker base and the loudspeaker peripheral connect through a contact connection or a non-contact connection, and provide personalized voice data corresponding to the role figure when connected.

Abstract: A preparation method of comb structure temperature/pH-responsive polycarboxylic acid adopts acrylic ester, temperature/pH-responsive monomer and other raw materials to obtain polycarboxylic acid via acrylate monomer self-polymerization, grafting with temperature/pH-responsive monomers and hydrolyzation. In other words, acrylate is used as the reaction monomer to polymerize polyacrylate with controllable molecular weight under the action of initiator and chain transfer agent, then the graft copolymers are copolymerized with temperature/pH-responsive monomers to obtain graft copolymers with acrylate polymers main chain and temperature/pH-responsive polymer side chains. Finally, the graft copolymer is hydrolyzed to obtain the comb structure temperature/pH-responsive polycarboxylic acid with polyacrylic acid main chain and temperature/pH-responsive monomer side chain.

Abstract: A loudspeaker system includes a loudspeaker base and a loudspeaker peripheral that is independent of the loudspeaker base. The loudspeaker peripheral is shaped as a role figure. The loudspeaker base and the loudspeaker peripheral connect through a contact connection or a non-contact connection, and provide personalized voice data corresponding to the role figure when connected.

Abstract: A star-shaped polyacrylamide copolymer and a preparation method thereof are provided, as well as a drilling fluid containing the star-shaped polyacrylamide copolymer. Only the star-shaped polyacrylamide copolymer is added into the drilling fluid; under a high-temperature environment, the filtration volume of the drilling fluid can be reduced, the high-temperature rheological property of the drilling fluid is improved, and the pressure loss of a circulation system of the drilling fluid is reduced.

Abstract: A preparation method of comb structure temperature/pH-responsive polycarboxylic acid adopts acrylic ester, temperature/pH-responsive monomer and other raw materials to obtain polycarboxylic acid via acrylate monomer self-polymerization, grafting with temperature/pH-responsive monomers and hydrolyzation. In other words, acrylate is used as the reaction monomer to polymerize polyacrylate with controllable molecular weight under the action of initiator and chain transfer agent, then the graft copolymers are copolymerized with temperature/pH-responsive monomers to obtain graft copolymers with acrylate polymers main chain and temperature/pH-responsive polymer side chains. Finally, the graft copolymer is hydrolyzed to obtain the comb structure temperature/pH-responsive polycarboxylic acid with polyacrylic acid main chain and temperature/pH-responsive monomer side chain.

Abstract: A method for preparing comb structure temperature/pH-responsive polycarboxylic acid by end-group functionalization adopts temperature/pH-responsive monomer, unsaturated halogenated hydrocarbon, small monomer of carboxylic acid and other raw materials to prepare polycarboxylic acid material via self-polymerization, substitution and copolymerization. Temperature/pH-responsive monomers are first self-polymerized to obtain temperature/pH-responsive polymer chain with end-group functionalization, and then substitution with unsaturated halogenated hydrocarbons is conducted to obtain temperature/pH-responsive macromonomers with end-group functionalization, finally the obtained product is copolymerized with small carboxylic acid monomers to prepare comb structure polymer with polycarboxylic acid main chain and temperature/pH-responsive side chain.