Patents by Inventor ZIMPLE MATHARU

ZIMPLE MATHARU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Integrated electrochemical detection and purification of nucleic acid biomarkers
    Patent number: 11209383
    Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: December 28, 2021
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
  • INTEGRATED ELECTROCHEMICAL DETECTION AND PURIFICATION OF NUCLEIC ACID BIOMARKERS
    Publication number: 20190137434
    Abstract: A biosensor platform apparatus and method are provided that can detect, purify and identify nucleic acid (DNA and RNA) biomarkers in complex biological fluids. The methods use a two-stage molecular based approach. The first stage screens for specific nucleic acid-based biomarkers in complex biological fluids by electrochemical detection of DNA:RNA hybridization and facilitates the removal of remaining complex media constituents. The first stage utilizes probes within a tunable nanoporous electrode. The second stage identifies the purified specific hybrids by single-molecule conductance measurements via break junction scanning. Identification can be assisted with a library of conductance measurements. The methods can provide strain level information that can be used for identifying anti-microbial resistance in detected pathogens. Collection of RNA targets allows for biomarker detection and identification without the need for amplification and can provide information about the viability of the sample organism.
    Type: Application
    Filed: October 31, 2018
    Publication date: May 9, 2019
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Erkin Seker, Joshua Hihath, Maria Marco, Paul Feldstein, Pallavi Daggumati, Yuanhui Li, Zimple Matharu, Juan Artes Vivancos
  • CONDUCTIVE HYDROGELS FOR AFFINITY SENSING
    Publication number: 20160291001
    Abstract: The present invention provides a sensor for detection of disease markers, and methods for detecting a disease marker, using a conductive hydrogel modified with a biorecognition element.
    Type: Application
    Filed: June 17, 2016
    Publication date: October 6, 2016
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: ALEXANDER REVZIN, ZIMPLE MATHARU, JUNGMOK YOU, LYDIA KWON, YING LIU, DONG-SIK SHIN