Patents by Inventor Zining LIU

Zining LIU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ifosfamide intermediate, preparation method and application thereof
    Patent number: 11479572
    Abstract: The invention discloses an ifosfamide intermediate, a preparation method and application thereof. The ifosfamide intermediate has formula I. The ifosfamide intermediate reacts with a chlorinating agent, and then cyclization is performed under the action of an organic base to obtain ifosfamide. Compared with the existing synthetic routes, the method of the invention has the advantages that the use of highly toxic and explosive ethyleneimine can be avoided, and the use of explosive chemicals can be avoided.
    Type: Grant
    Filed: October 2, 2021
    Date of Patent: October 25, 2022
    Assignee: HAINAN ZHUOKE PHARMACEUTICAL CO., LTD.
    Inventors: Zining Liu, Qiang Li, Yahui Liu
  • IFOSFAMIDE INTERMEDIATE, PREPARATION METHOD AND APPLICATION THEREOF
    Publication number: 20220119430
    Abstract: The invention discloses an ifosfamide intermediate, a preparation method and application thereof. The ifosfamide intermediate has formula I. The ifosfamide intermediate reacts with a chlorinating agent, and then cyclization is performed under the action of an organic base to obtain ifosfamide. Compared with the existing synthetic routes, the method of the invention has the advantages that the use of highly toxic and explosive ethyleneimine can be avoided, and the use of explosive chemicals can be avoided.
    Type: Application
    Filed: October 2, 2021
    Publication date: April 21, 2022
    Inventors: Zining LIU, Qiang LI, Yahui LIU