Patents by Inventor Ziqian ZHANG
Ziqian ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20250020637Abstract: A blood detection method is provided, including: treating a blood sample with a first reagent to obtain a test sample, wherein the first reagent includes a hemolytic agent for lysing red blood cells in the blood sample into fragments having light scattering characteristics significantly different from those of platelets; passing particles in the test sample through a detection area of an optical detection system one by one, to obtain optical information of the test sample; and obtaining optical information of platelets according to at least two types of the optical information of the test sample. In the method, a platelet count is obtained by lysing red blood cells in a blood sample, and white blood cell subpopulations can be also differentiated.Type: ApplicationFiled: September 6, 2024Publication date: January 16, 2025Inventors: Gengwen CHEN, Ziqian ZHANG, Yi YE, Zhaoyang LI
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Publication number: 20240361329Abstract: The disclosure provides a sample testing method and a sample analyzer, the method including: obtaining a sample to be tested; providing a reagent, the reagent including a hemolytic agent, a first fluorescent dye and a third fluorescent dye; mixing the sample and the reagent to form a sample solution; making the sample solution flow in a flow cell in a single test, irradiating the particles by using a first light source and a second light source, and detecting scattered light signals, first fluorescence signals and third fluorescence signals; obtaining a classification result and/or a counting result of white blood cells in the sample to be tested based on the first fluorescence signals and the scattered light signals; and obtaining a counting result of nucleated red blood cells in the sample to be tested based on the third fluorescence signals and the scattered light signals.Type: ApplicationFiled: July 10, 2024Publication date: October 31, 2024Inventors: Gengwen CHEN, Ziqian ZHANG
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Publication number: 20240344965Abstract: A reagent, a method for differentiating platelets under a hemolysis condition using the reagent and a blood cell analyzer are provided. The reagent includes a first reagent as a hemolytic agent, and a second reagent which is a membrane-specific dye or a mitochondrion-specific dye. By using the reagent, the method and the blood cell analyzer, platelets can be differentiated and an alarm about reticulocytes can be provided under a hemolysis condition, and white blood cell can further be classified and counted, thereby quickly and accurately analyzing a blood sample in a single channel.Type: ApplicationFiled: June 27, 2024Publication date: October 17, 2024Inventors: Gengwen CHEN, Ziqian ZHANG, Yi YE, Zhaoyang LI
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Patent number: 12092561Abstract: A reagent, a method for differentiating platelets under a hemolysis condition using the reagent and a blood cell analyzer are provided. The reagent includes a first reagent as a hemolytic agent, and a second reagent which is a membrane-specific dye or a mitochondrion-specific dye. By using the reagent, the method and the blood cell analyzer, platelets can be differentiated and an alarm about reticulocytes can be provided under a hemolysis condition, and white blood cell can further be classified and counted, thereby quickly and accurately analyzing a blood sample in a single channel.Type: GrantFiled: October 27, 2020Date of Patent: September 17, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Gengwen Chen, Ziqian Zhang, Yi Ye, Zhaoyang Li
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Patent number: 12092633Abstract: A blood detection method is provided, including: treating a blood sample with a first reagent to obtain a test sample, wherein the first reagent includes a hemolytic agent for lysing red blood cells in the blood sample into fragments having light scattering characteristics significantly different from those of platelets; passing particles in the test sample through a detection area of an optical detection system one by one, to obtain optical information of the test sample; and obtaining optical information of platelets according to at least two types of the optical information of the test sample. In the method, a platelet count is obtained by lysing red blood cells in a blood sample, and white blood cell subpopulations can be also differentiated.Type: GrantFiled: October 27, 2020Date of Patent: September 17, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Gengwen Chen, Ziqian Zhang, Yi Ye, Zhaoyang Li
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Patent number: 12038442Abstract: The disclosure provides a sample testing method and a sample analyzer, the method including: providing a sample and a reagent, the reagent including at least two fluorescent dyes for staining particles in the sample, wherein an absolute value of a difference between wavelengths corresponding to peaks of emission spectra of the two fluorescent dyes is greater than 30 nanometers and less than 80 nanometers, and an overlap between the emission spectra of the two fluorescent dyes is not greater than 50%; mixing the sample and the reagent to form a sample solution; flowing the sample solution in a flow cell in a single test, irradiating the particles flowing in the flow cell using light with a single wavelength; detecting at least fluorescence signals generated by the particles; and obtaining a test result of the sample based on at least the fluorescence signals.Type: GrantFiled: September 20, 2021Date of Patent: July 16, 2024Assignee: Shenzhen Mindray Bio-Medical Electronics Co., Ltd.Inventors: Gengwen Chen, Ziqian Zhang
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Publication number: 20230296591Abstract: A sample analysis method for analyzing a blood sample, a sample analyzer, and a computer-readable storage medium. Optical signals generated when particles in a test sample solution are illuminated by an excitation light when passing one by one through an optical detection area are acquired in one test, said sample solution being acquired when a blood sample is treated with a hemolytic agent, a first dye, and a second dye, the first dye being capable of dyeing white blood cells, the second dye being capable of dyeing infected red blood cells, the optical signals comprising a scattered light signal, a first fluorescent signal corresponding to the first dye, and a second fluorescent signal corresponding to the second dye; white blood cell optical information is acquired on the basis of the scattered light signal and of the first fluorescent signal; and red blood cell optical information is acquired on the basis of the scattered light signal and of the second fluorescent signal.Type: ApplicationFiled: May 30, 2023Publication date: September 21, 2023Inventors: Ziqian ZHANG, Gengwen CHEN
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Publication number: 20230280336Abstract: Disclosed are a leukocyte classification reagent and kit, a classification method, an erythrocyte classification reagent and kit, and an analysis method. Both the leukocyte classification reagent and the erythrocyte classification reagent comprise a fluorescent dye represented by the general formula F. The dye can stain the nucleic acids of leukocytes and erythrocytes, therefore, during blood analysis, the classification and/or counting of leukocytes in a sample can be accurately realized, and the classification and/or counting of erythrocytes in a sample can be accurately realized, in particular the identification and/or counting of RETs. In addition, the types of dyes used in blood cell analysis may also be simplified.Type: ApplicationFiled: May 12, 2023Publication date: September 7, 2023Inventors: Jiangli FAN, Gengwen CHEN, Tianping XIA, Yi YE, Ziqian ZHANG, Qichao YAO
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Publication number: 20230236285Abstract: The present application relates to radio detection and ranging (radar) systems and, in particular, to a radar system having a photonics-based signal generator. Such a radar system comprises a stepped-frequency optical signal generator, an optical-to-electrical converter, and a transmitter. The stepped-frequency optical signal generator is configured for converting an optical signal into a stepped-frequency optical signal. The optical-to-electrical converter for converting the stepped-frequency optical signal into a stepped-frequency electrical signal. The transmitter for transmitting a microwave signal based on the stepped-frequency electrical signal.Type: ApplicationFiled: April 30, 2021Publication date: July 27, 2023Inventors: Ziqian Zhang, Yang Liu, Benjamin John Eggleton
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Publication number: 20230152304Abstract: Disclosed is use of a composition for preventing and/or eliminating platelet aggregation in an in vitro blood sample. The composition comprises at least one compound selected from the group consisting of formula, R1-NH—R2, and a salt thereof. Also disclosed is an agent, which comprises the compound for reducing platelet aggregation interference in an in vitro blood test, and a method for preventing and/or eliminating platelet aggregation in a sample in an in vitro blood test. The compound of the present invention exhibits a disaggregation effect in multiple types of platelet aggregation circumstances, and the platelet disaggregation takes effect within a short time without additional conditions such as temperature control with water bath, prolonged reaction time and the like, thereby eliminating platelet aggregation in a sample conveniently and thus accurate blood cell detection parameters can be obtained.Type: ApplicationFiled: January 19, 2023Publication date: May 18, 2023Applicant: SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.Inventors: Fei GAO, Ziqian ZHANG
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Publication number: 20220091127Abstract: The disclosure provides a sample testing method and a sample analyzer, the method including: providing a sample and a reagent, the reagent including at least two fluorescent dyes for staining particles in the sample, wherein an absolute value of a difference between wavelengths corresponding to peaks of emission spectra of the two fluorescent dyes is greater than 30 nanometers and less than 80 nanometers, and an overlap between the emission spectra of the two fluorescent dyes is not greater than 50%; mixing the sample and the reagent to form a sample solution; flowing the sample solution in a flow cell in a single test, irradiating the particles flowing in the flow cell using light with a single wavelength; detecting at least fluorescence signals generated by the particles; and obtaining a test result of the sample based on at least the fluorescence signals.Type: ApplicationFiled: September 20, 2021Publication date: March 24, 2022Inventors: Gengwen CHEN, Ziqian ZHANG
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Publication number: 20210102935Abstract: A blood detection method is provided, including: treating a blood sample with a first reagent to obtain a test sample, wherein the first reagent includes a hemolytic agent for lysing red blood cells in the blood sample into fragments having light scattering characteristics significantly different from those of platelets; passing particles in the test sample through a detection area of an optical detection system one by one, to obtain optical information of the test sample; and obtaining optical information of platelets according to at least two types of the optical information of the test sample. In the method, a platelet count is obtained by lysing red blood cells in a blood sample, and white blood cell subpopulations can be also differentiated.Type: ApplicationFiled: October 27, 2020Publication date: April 8, 2021Inventors: Gengwen CHEN, Ziqian ZHANG, Yi YE, Zhaoyang LI
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Publication number: 20210041341Abstract: A reagent, a method for differentiating platelets under a hemolysis condition using the reagent and a blood cell analyzer are provided. The reagent includes a first reagent as a hemolytic agent, and a second reagent which is a membrane-specific dye or a mitochondrion-specific dye. By using the reagent, the method and the blood cell analyzer, platelets can be differentiated and an alarm about reticulocytes can be provided under a hemolysis condition, and white blood cell can further be classified and counted, thereby quickly and accurately analyzing a blood sample in a single channel.Type: ApplicationFiled: October 27, 2020Publication date: February 11, 2021Inventors: Gengwen CHEN, Ziqian ZHANG, Yi YE, Zhaoyang LI
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Publication number: 20170241402Abstract: A large-size wind power blade with a multi-beam structure and its manufacturing method, wherein the blade adopts a hollow layout structure and comprises a blade skin suction edge, a blade skin pressure edge, a main load-carrying structure crossbeam and anti-shearing webs, wherein the blade skin suction edge and the blade skin pressure edge are combined to form a cavity structure having a streamlined cross section, wherein a support structure formed by the combination of the main load-carrying structure crossbeam and the anti-shearing web is located in the cavity. Both the blade skin suction edge and the blade skin pressure edge adopt a multi-segment combined structure, wherein the multiple segments are connected to the side surface of the main load-carrying structure crossbeam to integrally form the blade skin suction edge and the skin pressure edge.Type: ApplicationFiled: March 18, 2015Publication date: August 24, 2017Applicant: ZHUZHOU TIMES NEW MATERIALS TECHNOLOGY CO., LTD.Inventors: Xuebing FENG, Chaoyi PENG, Jingcheng ZENG, Hang DENG, Fubiao YANG, Ziqian ZHANG