Patents by Inventor Zirui Li
Zirui Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11971452Abstract: A device and a method for nondestructively detecting a transient characteristic of a conductive screw of a turbo-generator rotor are provided. The device includes a personal computer (PC), an extremely-steep pulse generator, an ultra-high-frequency double-isolation transformer, and a pulse emitting and coupling module, which are connected in sequence. The pulse emitting and coupling module is connected to a load. A synchronous pulse receiving non-inductive divider circuit synchronously receives a characteristic waveform from the load, and the synchronous pulse receiving non-inductive divider circuit is connected to an ultra-high-speed analog/digital (A/D) module through a nonlinear saturation amplifying circuit that amplifies a signal. The PC receives a signal from the ultra-high-speed A/D module. The load includes a positive or negative excitation lead loop that is in a 180° symmetrical and instantaneous short-circuit state and a rotor shaft.Type: GrantFiled: April 25, 2021Date of Patent: April 30, 2024Assignee: HANGZHOU HENUOVA TECHNOLOGY CO., LTD.Inventors: Yuewu Zhang, Jianxi Liu, Yanxing Bao, Weihua Zha, Qianyi Zhang, Dongbing Liu, Weixing Yang, Xu Han, Miaoye Li, Zirui Wang, Junliang Liu, Jie Luo, Weitao Shen, Yu Fu, Han Gao
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Publication number: 20240112088Abstract: Systems and methods are provided for vector-quantized image modeling using vision transformers and improved codebook handling. In particular, the present disclosure provides a Vector-quantized Image Modeling (VIM) approach that involves pretraining a machine learning model (e.g., Transformer model) to predict rasterized image tokens autoregressively. The discrete image tokens can be encoded from a learned Vision-Transformer-based VQGAN (example implementations of which can be referred to as ViT-VQGAN). The present disclosure proposes multiple improvements over vanilla VQGAN from architecture to codebook learning, yielding better efficiency and reconstruction fidelity. The improved ViT-VQGAN further improves vector-quantized image modeling tasks, including unconditional image generation, conditioned image generation (e.g., class-conditioned image generation), and unsupervised representation learning.Type: ApplicationFiled: November 27, 2023Publication date: April 4, 2024Inventors: Jiahui Yu, Xin Li, Han Zhang, Vijay Vasudevan, Alexander Yeong-Shiuh Ku, Jason Michael Baldridge, Yuanzhong Xu, Jing Yu Koh, Thang Minh Luong, Gunjan Baid, Zirui Wang, Yonghui Wu
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Publication number: 20240108743Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.Type: ApplicationFiled: October 24, 2023Publication date: April 4, 2024Inventors: Qiang LI, Yuanli LI, Si CHEN, Zhu WANG, Zhao DONG, Zirui LI, Xinlu MA, Lu YANG, Yongjuan GAO, Yuncheng ZHENG, Naichao SUN
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Patent number: 11833212Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.Type: GrantFiled: August 2, 2021Date of Patent: December 5, 2023Assignee: AMPSOURCE BIOPHARMA SHANGHAI INC.Inventors: Qiang Li, Yuanli Li, Si Chen, Zhu Wang, Zhao Dong, Zirui Li, Xinlu Ma, Lu Yang, Yongjuan Gao, Yuncheng Zheng, Naichao Sun
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Patent number: 11472863Abstract: A hyperglycosylated recombinant human coagulation factor IX (FIX) fusion protein, a preparation method therefor, and use thereof. The fusion protein sequentially comprises, from N- to C-terminus, a human FIX, a flexible peptide linker, at least one human chorionic gonadotropin ? subunit carboxy-terminal peptide rigid unit, and a half-life extending moiety. The fusion protein has a biological activity similar to that of the recombinant FIX, an extended in vivo activity half-life, and reduced immunogenicity, so as to improve pharmacokinetics and pharmacodynamics.Type: GrantFiled: April 10, 2017Date of Patent: October 18, 2022Assignees: Ampsource Biopharma Shanghai Inc., Pharmab, Inc.Inventors: YongJuan Gao, Si Chen, Zirui Li, Xiaoping Tu, Bill Nai-chau Sun, Qiang Li
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Publication number: 20220105193Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.Type: ApplicationFiled: August 2, 2021Publication date: April 7, 2022Inventors: Qiang LI, Yuanli LI, Si CHEN, Zhu WANG, Zhao DONG, Zirui LI, Xinlu MA, Lu YANG, Yongjuan GAO, Yuncheng ZHENG, Naichao SUN
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Publication number: 20210380654Abstract: A fusion protein of hFGF21 or its analogs having improved pharmaceutical properties, and use of the fusion protein in preparing medicines for treating diseases, such as diabetes, obesity, non-alcoholic fatty liver disease, dyslipidemia, and/or metabolic syndrome.Type: ApplicationFiled: April 10, 2017Publication date: December 9, 2021Applicant: AMPSOURCE BIOPHARMA SHANGHAI INC.Inventors: Zhao DONG, Chi ZHOU, Xiong FENG, Zirui LI, Yuanli LI, Qiang LI
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Patent number: 11162227Abstract: A boltless fastener assembly for a heavy haul railway with an axle load of 35-40 tons includes a pre-embedded steel holder, an e-clip, an insulated gauge block and a rubber pad. A clamping leg-heel end of the e-clip is provided with an L-shaped retaining end. The pre-embedded steel holder is improved to adapt to the e-clip, and an opening is formed at a portion of the pre-embedded steel holder close to the clamping leg-heel end of the e-clip, so that the e-clip can be installed normally. During normal installation, the L-shaped retaining end of the e-clip does not contact the pre-embedded steel holder. When the rail undergoes large torsional deformation, the L-shaped retaining end on one side of a rail moves upward to contact an upper edge of the opening of the pre-embedded steel holder or engages with a second heel end.Type: GrantFiled: June 5, 2018Date of Patent: November 2, 2021Assignees: CHINA ACADEMY OF RAILWAY SCIENCES CORPORATION LIMITED RAILWAY ENGINEERING RESEARCH INSTITUTE, CHINA ACADEMY OF RAILWAY SCIENCES CORPORATION LIMITEDInventors: Junheng Xiao, Hangwei Fang, Zirui Li, Yanshan Li, Chengliang Li, Haoyong Yu, Liangshan Xu, Zhen Pan
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Patent number: 11123438Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.Type: GrantFiled: November 16, 2016Date of Patent: September 21, 2021Assignee: AMPSOURCE BIOPHARMA SHANGHAI INC.Inventors: Qiang Li, Yuanli Li, Si Chen, Zhu Wang, Zhao Dong, Zirui Li, Xinlu Ma, Lu Yang, Yongjuan Gao, Yuncheng Zheng, Naichao Sun
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Publication number: 20210230809Abstract: A boltless fastener assembly for a heavy haul railway with an axle load of 35-40 tons includes a pre-embedded steel holder, an e-clip, an insulated gauge block and a rubber pad. A clamping leg-heel end of the e-clip is provided with an L-shaped retaining end. The pre-embedded steel holder is improved to adapt to the e-clip, and an opening is formed at a portion of the pre-embedded steel holder close to the clamping leg-heel end of the e-clip, so that the e-clip can be installed normally. During normal installation, the L-shaped retaining end of the e-clip does not contact the pre-embedded steel holder. When the rail undergoes large torsional deformation, the L-shaped retaining end on one side of a rail moves upward to contact an upper edge of the opening of the pre-embedded steel holder or engages with a second heel end.Type: ApplicationFiled: June 5, 2018Publication date: July 29, 2021Applicants: CHINA ACADEMY OF RAILWAY SCIENCES CORPORATION LIMITED RAILWAY ENGINEERING RESEARCH INSTITUTE, CHINA ACADEMY OF RAILWAY SCIENCES CORPORATION LIMITEDInventors: Junheng XIAO, Hangwei FANG, Zirui LI, Yanshan LI, Chengliang LI, Haoyong YU, Liangshan XU, Zhen PAN
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Publication number: 20200157185Abstract: A hyperglycosylated recombinant human coagulation factor IX (FIX) fusion protein, a preparation method therefor, and use thereof. The fusion protein sequentially comprises, from N- to C-terminus, a human FIX, a flexible peptide linker, at least one human chorionic gonadotropin ? subunit carboxy-terminal peptide rigid unit, and a half-life extending moiety. The fusion protein has a biological activity similar to that of the recombinant FIX, an extended in vivo activity half-life, and reduced immunogenicity, so as to improve pharmacokinetics and pharmacodynamics.Type: ApplicationFiled: April 10, 2017Publication date: May 21, 2020Inventors: YongJuan Gao, Si Chen, Zirui Li, Xiaoping Tu, Bill Nai-chau Sun, Qiang Li
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Publication number: 20190184026Abstract: A linker peptide for constructing a fusion protein. The linker peptide comprises a flexible peptide and a rigid peptide. The flexible peptide consists of one or more flexible units. The rigid peptide consists of one or more rigid units. The flexible unit comprises two or more amino acid residues selected from Gly, Ser, Ala, and Thr. The rigid unit comprises a human chorionic gonadotropin ?-subunit carboxy-terminal peptide (CTP) bearing a plurality of glycosylation sites. The linker peptide can more effectively eliminate mutual steric hindrance of two fusion molecules, decreasing a reduction/loss of polymerization or activity resulting from improper folding of an active protein or a conformational change. On the other hand, the negatively charged, highly sialylated CTP can resist renal clearance, further prolonging a half-life of a fused molecule and enhancing bioavailability of a fused protein.Type: ApplicationFiled: November 16, 2016Publication date: June 20, 2019Inventors: Qiang LI, Yuanli LI, Si CHEN, Zhu WANG, Zhao DONG, Zirui LI, Xinlu MA, Lu YANG, Yongjuan GAO, Yuncheng ZHENG, Naichao SUN
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Publication number: 20040009459Abstract: The invention provides a system for the simulation of image-guided medical procedures and methods of using the same. The system can be used for training and certification, pre-treatment planning, as well therapeutic device design, development and evaluation.Type: ApplicationFiled: May 5, 2003Publication date: January 15, 2004Inventors: James H. Anderson, Anthony C. Venbrux, Kieran P. Murphy, Meiyappan Solaiyappan, Chee-Kong Chui, Zirui Li, Xin Ma, Zhen L. Wang, Jeremy Teo