Patents by Inventor Zishen Wang

Zishen Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2-isopropylmalate synthetase and engineering bacteria and application thereof
    Patent number: 11866737
    Abstract: The invention relates to a 2-isopropyl malate synthase, a genetically engineered bacterium for producing L-leucine and application thereof and belongs to the field of metabolic engineering. The genetically engineered bacterium is obtained by overexpressing an isopropyl malate synthase coding gene leuAM for relieving feedback inhibition by L-leucine, an acetohydroxy acid synthase coding gene ilvBNM for relieving feedback inhibition by L-isoleucine, a 3-isopropyl malate dehydrogenase coding gene leuB and a 3-isopropyl malate dehydratase coding gene leuCD in host cells. The genetically engineered bacterium for producing the L-leucine is free from nutritional deficiency, rapid in growth, short in fermentation period, high in yield and high in conversion rate.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: January 9, 2024
    Assignee: Tianjin University of Science and Technology
    Inventors: Chenglin Zhang, Qingyang Xu, Yanjun Li, Yu Zhang, Yingzi Li, Fuzhou Zhu, Nan Lu, Shibao Han, Xierong Dong, Zishen Wang, Hao Xu, Ziyi Li
  • 2-ISOPROPYLMALATE SYNTHETASE AND ENGINEERING BACTERIA AND APPLICATION THEREOF
    Publication number: 20210189354
    Abstract: The invention relates to a 2-isopropyl malate synthase, a genetically engineered bacterium for producing L-leucine and application thereof and belongs to the field of metabolic engineering. The genetically engineered bacterium is obtained by overexpressing an isopropyl malate synthase coding gene leuAM for relieving feedback inhibition by L-leucine, an acetohydroxy acid synthase coding gene ilvBNM for relieving feedback inhibition by L-isoleucine, a 3-isopropyl malate dehydrogenase coding gene leuB and a 3-isopropyl malate dehydratase coding gene leuCD in host cells. The genetically engineered bacterium for producing the L-leucine is free from nutritional deficiency, rapid in growth, short in fermentation period, high in yield and high in conversion rate.
    Type: Application
    Filed: December 29, 2020
    Publication date: June 24, 2021
    Inventors: Chenglin Zhang, Qingyang Xu, Yanjun Li, Yu Zhang, Yingzi Li, Fuzhou Zhu, Nan Lu, Shibao Han, Xierong Dong, Zishen Wang, Hao Xu, Ziyi Li