Patents by Inventor Zita Hubler

Zita Hubler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20230000798
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: May 27, 2022
    Publication date: January 5, 2023
    Inventors: Paul J. Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • Compounds and methods of promoting myelination
    Patent number: 11344511
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: May 31, 2022
    Assignee: Case Western Reserve University
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu, Steven B. Landau
  • COMPOUNDS FOR TREATING MYELIN RELATED DISORDERS
    Publication number: 20210353642
    Abstract: Disclosed is a pharmaceutical composition comprising a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent. Also disclosed is a method of treating a myelin related disorder in a subject, the method comprising administering to the subject an effective amount of a compound of Structural Formula (I) or a pharmaceutical composition comprising the compound of Structural Formula (I). The variables of Structural Formula (I) are described herein.
    Type: Application
    Filed: October 1, 2019
    Publication date: November 18, 2021
    Inventors: Drew Adams, Paul J. Tesar, Dharmaraja Allimuthu, Zita Hubler, Fadi J. Najm
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20210121481
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of 8,9-unsaturated sterols in the OPCs, the agent comprising a compound having the formula (I): wherein variables Y1, R1 and R2 are as defined herein.
    Type: Application
    Filed: April 17, 2019
    Publication date: April 29, 2021
    Inventors: Drew Adams, Dharmaraja Allimuthu, Zita Hubler
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20190269670
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: July 27, 2017
    Publication date: September 5, 2019
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu
  • COMPOUNDS AND METHODS OF PROMOTING MYELINATION
    Publication number: 20180228743
    Abstract: A method of promoting the generation of oligodendrocytes from oligodendrocyte precursor cells by enhancing their survival and/or maturation includes administering to the cell an effective amount of an agent that enhances and/or induces accumulation of ?8,9-unsaturated sterol intermediates of the cholesterol biosynthesis pathway in the oligodendrocyte precursor cells.
    Type: Application
    Filed: January 25, 2018
    Publication date: August 16, 2018
    Inventors: Paul Tesar, Drew Adams, Zita Hubler, Matthew Elitt, Dharmaraja Allimuthu