Abstract: Single and multiple allergy skin testing devices with rigid annular pain-reduction structures supported by respective compressible sleeves. Each rigid annular pain-reduction structure presses against skin before and while at least one corresponding sharp probe presses against the skin surrounded by the rigid annular pain-reduction structure, thereby causing a surrounding pain gate effect to reduce perceived pain due to the at least one sharp probe. Each allergy skin testing device includes: a central post having a sharp portion, a longitudinal portion, and a guide portion; a compressible structure having a leading portion, a resilient compressible portion, and a base portion; and a rigid annular probe portion having an annular skin-contacting surface.

Abstract: An allergy skin testing device includes a central post having a sharp portion, a longitudinal portion, and a guide portion. The sharp portion has one or more sharp probes extending longitudinally. The guide portion facilitates guiding the sharp portion towards the skin. The device also includes a compressible annular pain-reduction structure having an annular dull probe portion, a resilient compressible portion, and an optional base portion. The annular dull probe portion initially extends beyond the sharp portion, and has a passageway allowing passage of the sharp portion therethrough, the annular dull probe portion being configured to activate a surrounding pain gate effect (a “pain gate fence”) when pressed against the skin. The resilient compressible portion is configured to compress along the longitudinal portion of the central post. The base portion is configured to be pushed by the guide portion when the annular dull probe portion is pressed against the skin.

Abstract: An allergy skin testing device is disclosed that includes at least one central post having at least one sharp probe extending longitudinally from an end of the at least one central post, the at least one sharp probe being for administering an allergen to skin. For each central post, at least three dull probes substantially surround the at least one sharp probe, creating a “pain gate fence”, the at least three dull probes being for activating a pain gate effect affecting nerves of the skin while the at leat one sharp probe administers the allergen to the skin. The at least three dull probes extend further along the central post than the at least one sharp probe, so when all the probes are pressed against the skin using a gripping portion, the plurality of dull probes press into the skin before the at least one sharp probe penetrates the skin.

Abstract: Sublingual immunotherapy (SLIT) with reduced oral itchiness is disclosed. The improved sublingual immunotherapy combines a monotonically increasing dose of allergen, along with a constant dose of mast cell stabilizer, thereby substantially avoiding the oral itchiness and other uncomfortable adverse reactions typically experienced with SLIT, which can improve patient compliance. An antihistamine and/or a leukotriene inhibitor can also be added along with the mast cell stabilizer. Multi-layer and/or coated tablets, and flexible paired ampoules with special features to advantageously time the dose of the allergen relative to the dose of the mast cell stabilizer, have been provided to effectively administer the improved sublingual immunotherapy in a highly convenient manner.

Abstract: A method and formulation for the prevention and treatment for Oral Allergy Syndrome (OAS), also referred to as Pollen-associated Food Allergy Syndrome (PFAS), is disclosed. The formulation significantly reduces or prevents symptoms related to Oral Allergy Syndrome while having a superb safety record. It can significantly improve Quality of Life for millions of patients afflicted with OAS.

Abstract: A breast examination system is disclosed that facilitates normalized quantitative comparison of results from multiple examinations performed under differing conditions, such as different viewing angles. The proposed system can operate on a camera-equipped smart-phone, a camera-equipped desk-top computer, or on a dedicated device to perform a guided breast cancer examination, and then store results of the examination in a normalized format that allows effective quantitative comparison to historic results, thereby detecting changes and trends. The results can be stored on the local device, or on a web-based server, providing various data comparison, data management, and data interpretation services in a secure and controlled manner.

Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.

Abstract: A palm-held device is disclosed for injection of a substance into an organism. The palm-held device has the shape of a computer mouse, and so is very familiar, which helps with ease-of-use and comfort. Like a computer mouse, the device can be moved easily by gently holding and guiding the mouse with the fingers and the palm of the hand. There are many possible button configurations, such as a single button mouse, the button having a large surface at the front top portion of the mouse, and being pressable by any finger. There can also be a two button mouse, such that the left button actuates the injection, and the right button is the “safety” that allows the left button to actuate the injection. The two buttons can be on the top front of the mouse, or can be on the right and left sides of the mouse.

Abstract: A method of applying a topical preparation of at least one of a mast cell stabilizer, an antihistamine, and a leukotriene inhibitor is disclosed for prevention and/or treatment of oral allergy syndrome of the lips, including lip itchiness and/or swelling. For example, topical application of Cromolyn Sodium to the lips can be used to prevent and/or treat allergic reaction to consumption or other contact with raw fruits and/or raw vegetables. The topical administration can be performed by using applicator devices that apply at least one of a mast cell stabilizer and an antihistamine in the form of a liquid, or a gel, or a butter, or a wax-like solid, or a liposome suspension. Applicator devices can include at least one of: a roller, a brush, a sponge, a swab, a tube, a lipstick. The taste of the at least one of a mast cell stabilizer and an antihistamine can be masked by flavors.

Abstract: A website and method are disclosed for helping a recommender to provide confidential recommendations for individuals. The system enables the recommender to efficiently comply with multiple requests for confidential recommendations, and to efficiently comply with a single request for a confidential recommendation to be sent to multiple institutions. The system eliminates the need to write multiple confidential recommendations when the individual applies to multiple institutions by enabling the recommender to distribute multiple links to the same confidential recommendation. The system also enables the recommender to easily edit the recommendation before or after multiple links have been distributed, thereby ensuring that the recommender retains control over the content of the confidential recommendation. The control over the recommendation link also includes a capability for changing the link expiration date, temporarily suspending or re-activating a link, and deleting a link.

Abstract: A website and method are disclosed for helping an anonymous individual to publicly disclose anonymous information about the anonymous individual so as to facilitate discovery of the anonymous individual by potential employers interested in hiring the anonymous individual. The website and method reduce risk to the anonymous individual of negative consequences of public disclosure of information about the anonymous individual. The website and method also inherently encourage disclosure to potential employers of more comprehensive information about the anonymous individual.

Abstract: Treatment or prevention of oral allergy syndrome, or other allergy-related oral inflammatory processes using a topical preparation of at least one of a mast cell stabilizer and an antihistamine is disclosed. For example, the topical administration of Cromolyn Sodium prior to ingestion of raw fruits and raw vegetables may be used to prevent oral allergy symptoms. The topical administration can be performed by use of a solution, a powder, an aerosol, a tablet, a chewable tablet, a gel, a melting strip, a mouth rinse, a mouth swab, or a piece of candy, and may be combined with carrier molecules and/or mucoadhesive molecules to enhance efficacy.

Abstract: A breast examination system is disclosed that facilitates normalized quantitative comparison of results from multiple examinations performed under differing conditions, such as different viewing angles. The proposed system can operate on a camera-equipped smart-phone, a camera-equipped desk-top computer, or on a dedicated device to perform a guided breast cancer examination, and then store results of the examination in a normalized format that allows effective quantitative comparison to historic results, thereby detecting changes and trends. The results can be stored on the local device, or on a web-based server, providing various data comparison, data management, and data interpretation services in a secure and controlled manner.

Abstract: A palm-controlled device is disclosed for injection of a substance into an organism. The device includes a palm-receiving surface for receiving a palm of a hand, the palm receiving surface being shaped so that the palm is substantially parallel to a surface of an injection site of the organism while operating the device. The palm receiving surface can also be shaped so that the palm is substantially perpendicular to a surface of the injection site. The device also includes an injector having at least one pre-filled syringe, the palm-receiving surface being cooperative with the injector such that when pressure is applied to the palm-receiving surface, the injector is actuated so as to inject contents of the at least one pre-filled syringe. Actuation of the injector is by gradual pressure; not sudden motion. Single or multiple doses of same or different medications can be included in a single injector.

Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.

Abstract: An allergy skin test device is disclosed that causes less pain than commonly used devices that include multi-point sharp puncture heads. The allergy skin test device incorporates multiple dull pressure heads distributed amongst the sharp multi-point sharp puncture heads, each dull pressure head activating a neurological pain gate that reduces pain sensation typically caused by the neighboring multi-point head when it engages the skin.