Patents by Inventor Zixiang GUO

Zixiang GUO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Attenuated strain of African swine fever virus (ASFV) with IPTG-induced deletion of gene and use thereof
    Patent number: 11987797
    Abstract: The present disclosure belongs to the technical field of biology, and in particular relates to an attenuated strain of African swine fever virus (ASFV) with IPTG-induced deletion of a D1133L gene and use thereof. In the present disclosure, it is firstly found that the D1133L protein of ASFV can inhibit production of IFN-? and downstream cytokines ISG-15 and ISG-56, and can be used as an immunosuppressant with a relatively strong immunosuppressive effect. In addition, the attenuated strain of ASFV with IPTG-induced deletion of the D1133L gene is constructed. Specifically, a screening expression cassette is inserted into a position before the non-structural protein gene D1133L of the ASFV using an Escherichia coli lac operator-repressor system, to obtain a recombinant virus. In the presence of the IPTG, the recombinant virus has similar characteristics to a wild-type virus; and in the absence of the IPTG, the expression of the D1133L protein is inhibited.
    Type: Grant
    Filed: November 21, 2022
    Date of Patent: May 21, 2024
    Assignee: LANZHOU VETERINARY RESEARCH INSTITUTE, CHINESE ACADEMY OF AGRICULTURAL SCIENCES
    Inventors: Haixue Zheng, Keshan Zhang, Ting Zhang, Tao Feng, Bo Yang, Xing Yang, Xijuan Shi, Hong Tian, Yi Ru, Fan Yang, Zixiang Zhu, Jianhong Guo, Jijun He, Xiangtao Liu
  • Derivatives of amanita toxins and their conjugation to a cell binding molecule
    Patent number: 10836796
    Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , -----, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
    Type: Grant
    Filed: April 20, 2016
    Date of Patent: November 17, 2020
    Assignee: HANGZHOU DAC BIOTECH CO., LTD.
    Inventors: Robert Yongxin Zhao, Qingliang Yang, Yuanyuan Huang, Shun Gai, Hangbo Ye, Chengyu Yang, Huihui Guo, Xiaomai Zhou, Hongsheng Xie, Qianqian Tong, Minjun Cao, Linyao Zhao, Junxiang Jia, Wenjun Li, Xiaotao Zuo, Chen Lin, Yifang Xu, Zixiang Guo
  • DERIVATIVES OF AMANITA TOXINS AND THEIR CONJUGATION TO A CELL BINDING MOLECULE
    Publication number: 20200079820
    Abstract: The present invention is related to novel cytotoxic agents, derivatives of Amanita toxins of Formula (I), wherein , - - - , R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, X, L, m, n and Q are defined herein, the preparation and the therapeutic uses in the targeted treatment of cancers, autoimmune disorders, and infectious diseases.
    Type: Application
    Filed: April 20, 2016
    Publication date: March 12, 2020
    Applicant: Hangzhou DAC Biotech Co., Ltd.
    Inventors: Robert Yongxin ZHAO, Qingliang YANG, Yuanyuan HUANG, Shun GAI, Hangbo YE, Chengyu YANG, Huihui GUO, Xiaomai ZHOU, Hongsheng XIE, Qianqian TONG, Minjun CAO, Linyao ZHAO, Junxiang JIA, Wenjun LI, Xiaotao ZUO, Chen LIN, Yifang XU, Zixiang GUO