Patents by Inventor Zixiao SHI

Zixiao SHI has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240043801
    Abstract: Provided are a preparation method for a tumor-infiltrating lymphocyte, and use thereof, particularly relating to a method for culturing a tumor-infiltrating lymphocyte, comprising: subjecting a TIL, which is derived from tumor tissues and not expanded in vitro, to in vitro expansion of at least one stage, and wherein the TIL is contacted with a CD28 agonist in the in vitro expansion of at least one stage. Further provided is a method for preventing and/or treating tumors by using the tumor-infiltrating lymphocyte.
    Type: Application
    Filed: December 23, 2021
    Publication date: February 8, 2024
    Inventors: Yarong LIU, Peipei ZHAO, Zixiao SHI
  • Publication number: 20210221903
    Abstract: The disclosure relates to a BCMA-targeting chimeric antigen receptor and uses thereof. Specifically, the disclosure provides a polynucleotide sequence selected from the group consisting of: (1) a polynucleotide sequence comprising, linked in sequence, a sequence encoding an anti-BCMA single chain antibody, a sequence encoding the hinge region of human CD8?, a sequence encoding the transmembrane region of human CD8, a sequence encoding the intracellular domain of human 41BB, a sequence encoding the intracellular domain of human CD3? and optionally a sequence encoding a fragment of EGFR comprising the extracellular domain III and the extracellular domain IV; and (2) a complementary sequence of the polynucleotide sequence of (1). The disclosure further provides corresponding fusion proteins and vectors comprising the coding sequence, as well as uses of the fusion proteins, coding sequences and vectors.
    Type: Application
    Filed: August 14, 2018
    Publication date: July 22, 2021
    Inventors: Yarong LIU, Feng HE, Haiying WANG, Zixiao SHI