Patents by Inventor Zixing HAN

Zixing HAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Patent number: 12173010
    Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
    Type: Grant
    Filed: May 12, 2023
    Date of Patent: December 24, 2024
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Haotao Niu, Zhenwu Wang, Zixing Han, Liangshan Tao, Jifang Weng, Zhe Shi
  • Heterocyclic compounds, preparation methods and uses thereof
    Patent number: 12110289
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).
    Type: Grant
    Filed: July 1, 2021
    Date of Patent: October 8, 2024
    Assignee: InventisBio Co., Ltd.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Zhe Shi, Zhenwu Wang, Liangshan Tao, Zixing Han, Haotao Niu, Jifang Weng
  • Use of strain in controlling fusarium crown rot of wheat
    Patent number: 11998016
    Abstract: The present disclosure provides use of a Chaetomium globosum strain in controlling Fusarium crown rot (FCR) of wheat. The C. globosum strain under the deposit designation of 12XP1-2-3 is deposited at China General Microbiological Culture Collection Center (CGMCC) on Jan. 23, 2019 with an accession number of CGMCC No. 17183. Field experiments conclude that coating of wheat seeds with Chaetomium globosum strain 12XP1-2-3 can reduce diseased stem rate, disease rating, and disease index by 19.0%-41.3%, 43.7%, and 4.7%-45.4%, respectively.
    Type: Grant
    Filed: April 19, 2021
    Date of Patent: June 4, 2024
    Assignee: Institute of Plant Protection, Henan Academy of Agricultural Sciences
    Inventors: Fei Xu, Yuli Song, Junmei Wang, Jiaojiao Zhang, Zixing Han, Yahong Li, Ruijie Shi, Lijuan Li, Lulu Liu
  • HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20240140929
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable N salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.
    Type: Application
    Filed: December 22, 2021
    Publication date: May 2, 2024
    Inventors: Xing DAI, Xianhai HUANG, Hong YANG, Zixing HAN, Haotao NIU, Jifang WENG, Zhe SHI, Yanqin LIU, Yueheng JIANG, Yaolin WANG
  • HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20230357233
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (A), Formula (II), Formula (III), Formula (IV), or Formula (V), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer (e.g., non-small cell lung cancer) or endometrial cancer.
    Type: Application
    Filed: August 26, 2021
    Publication date: November 9, 2023
    Inventors: Xing DAI, Hong YANG, Xianhai HUANG, Haotao NIU, Zixing HAN, Zhenwu WANG, Qiang ZHANG, Yanqin LIU, Yueheng JIANG, Liangshan TAO, Jifang WENG, Zhe SHI, Yaolin WANG
  • HETEROCYCLIC COMPOUNDS, PREPARATION METHODS THEREFOR, AND METHODS OF USES THEREOF
    Publication number: 20230357260
    Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
    Type: Application
    Filed: May 12, 2023
    Publication date: November 9, 2023
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Haotao NIU, Zhenwu WANG, Zixing HAN, Liangshan TAO, Jifang WENG, Zhe SHI
  • QUINAZOLINE COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20230242544
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.
    Type: Application
    Filed: June 30, 2021
    Publication date: August 3, 2023
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Haotao NIU, Yanqin LIU, Hong YANG, Zixing HAN, Zhenwu WANG, Liangshan TAO, Qiang ZHANG, Zhe SHI, Jifang WENG
  • Heterocyclic compounds, preparation methods therefor, and methods of uses thereof
    Patent number: 11691981
    Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
    Type: Grant
    Filed: June 24, 2020
    Date of Patent: July 4, 2023
    Assignee: INVENTISBIO CO., LTD.
    Inventors: Xing Dai, Yaolin Wang, Yueheng Jiang, Yanqin Liu, Haotao Niu, Zhenwu Wang, Zixing Han, Liangshan Tao, Jifang Weng, Zhe Shi
  • USE OF CHAETOMIUM GLOBOSUM STRAIN IN CONTROLLING FUSARIUM CROWN ROT OF WHEAT
    Publication number: 20220053771
    Abstract: The present disclosure provides use of a Chaetomium globosum strain in controlling Fusarium crown rot (FCR) of wheat. The C. globosum strain under the deposit designation of 12XP1-2-3 is deposited at China General Microbiological Culture Collection Center (CGMCC) on Jan. 23, 2019 with an accession number of CGMCC No. 17183. Field experiments conclude that coating of wheat seeds with Chaetomium globosum strain 12XP1-2-3 can reduce diseased stem rate, disease rating, and disease index by 19.0%-41.3%, 43.7%, and 4.7%-45.4%, respectively.
    Type: Application
    Filed: April 19, 2021
    Publication date: February 24, 2022
    Inventors: Fei Xu, Yuli Song, Junmei Wang, Jiaojiao Zhang, Zixing Han, Yahong Li, Ruijie Shi, Lijuan Li, Lulu Liu
  • ISOLATE OF CHAETOMIUM GLOBOSUM AND ITS APPLICATION IN WHEAT GROWTH PROMOTION AND YIELD INCREASE
    Publication number: 20220056399
    Abstract: This invention provides an isolate of Chaetomium globosum, which is numbered as 12XP1-2-3, preserved by China General Microbiological Culture Collection Center with CGMCC No. 17183 on Jan. 23, 2019. This invention also provides an application of Chaetomium globosum in wheat growth promotion and yield increase. The results of field trials showed that by coating wheat seeds with Chaetomium globosum 12XP1-2-3, the chlorophyll content of leaves can be increased by 1.9%-14.7% at booting stage, and the wheat yield can be increased by 2.3%-10.9%.
    Type: Application
    Filed: July 6, 2021
    Publication date: February 24, 2022
    Inventors: Yuli SONG, Fei XU, Junmei WANG, Zixing HAN, Yahong LI, Chaohong FENG
  • C-TERMINAL SRC KINASE INHIBITORS
    Publication number: 20220040176
    Abstract: Provided herein are novel C-terminal Srk Kinase (CSK) inhibitors, e.g., having Formula G, I, II, or III. Also provided are methods of preparing the novel CSK inhibitors and method of using the novel CSK inhibitors for treating diseases or disorder such as cancer or for promoting immune response in a subject in need thereof.
    Type: Application
    Filed: December 17, 2019
    Publication date: February 10, 2022
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Zhe SHI, Zhenwu WANG, Zixing HAN, Liangshan TAO
  • THYROID HORMONE RECEPTOR AGONISTS
    Publication number: 20210355110
    Abstract: Provided herein are novel thyroid hormone receptor (TR) agonists e.g., having Formula I, II, or III. Also provided are methods of preparing the novel TR agonists and method of using the novel TR agonists for treating diseases or disorder modulated by TR agonists, such as NAFLD, NASH, diabetes, hyperlipidemia and/or hypercholesterolemia.
    Type: Application
    Filed: October 11, 2019
    Publication date: November 18, 2021
    Inventors: Dai XING, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Zixing HAN, Zhenwu WANG, Liangshan TAO, Zhe SHI
  • HETEROCYCLIC COMPOUNDS, PREPARATION METHODS AND USES THEREOF
    Publication number: 20210355125
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).
    Type: Application
    Filed: July 1, 2021
    Publication date: November 18, 2021
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Zhe SHI, Zhenwu WANG, Liangshan TAO, Zixing HAN, Haotao NIU, Jifang WENG
  • HETEROCYCLIC COMPOUNDS, PREPARATION AND METHODS AND USES THEREOF
    Publication number: 20210198255
    Abstract: Provided herein are novel compounds, for example, compounds having a Formula (I) or Formula (II), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRAS G12C in a cell, and/or in treating various cancer such as pancreatic cancer, endometrial cancer, colorectal cancer, or lung cancer (e.g., non-small cell lung cancer).
    Type: Application
    Filed: February 10, 2021
    Publication date: July 1, 2021
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Zhe SHI, Zhenwu WANG, Liangshan TAO, Zixing HAN, Haotao NIU, Jifang WENG
  • HETEROCYCLIC COMPOUNDS, PREPARATION METHODS THEREFOR, AND METHODS OF USES THEREOF
    Publication number: 20210017187
    Abstract: Provided herein are novel heterocyclic compounds, for example, compounds having Formula I. Also provided herein are methods of preparing the compounds and methods of using the same, for example, in inhibiting TGF-beta mediated signaling and/or for treating cancer.
    Type: Application
    Filed: June 24, 2020
    Publication date: January 21, 2021
    Inventors: Xing DAI, Yaolin WANG, Yueheng JIANG, Yanqin LIU, Haotao NIU, Zhenwu WANG, Zixing HAN, Liangshan TAO, Jifang WENG, Zhe SHI