Patents by Inventor Ziying Yan

Ziying Yan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Transgenic Animal Models of Disease
    Publication number: 20120180141
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Application
    Filed: November 3, 2011
    Publication date: July 12, 2012
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall S. Prather, John Engelhardt, Ziying Yan
  • Method of identifying compounds using a transgenic pig model of cystic fibrosis
    Patent number: 7989675
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Grant
    Filed: March 5, 2008
    Date of Patent: August 2, 2011
    Assignees: University of Iowa Research Foundation, The Curators of the University of Missouri
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall Prather, John Engelhardt, Ziying Yan
  • METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES
    Publication number: 20110054247
    Abstract: The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.
    Type: Application
    Filed: July 13, 2010
    Publication date: March 3, 2011
    Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
    Inventors: XINGSHEN SUN, YALING YI, GREGORY H. LENO, JOHN F. ENGELHARDT, ZIYING YAN, MICHAEL J. WELSH, CHRIS ROGERS, Xiaoming Liu
  • Compounds and methods to enhance rAAV transduction
    Patent number: 7749491
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Grant
    Filed: March 31, 2004
    Date of Patent: July 6, 2010
    Assignees: University of Iowa Research Foundation, Targeted Genetics Corporation
    Inventors: John F. Engelhardt, Keith L. Munson, Ziying Yan
  • METHODS FOR CLONING FERRETS AND TRANSGENIC FERRET MODELS FOR DISEASES
    Publication number: 20090241206
    Abstract: The invention provides a transgenic Mustelidae in which a gene associated with a human disease or condition comprises a targeted genetic modification, and uses thereof. Also provided is a method to cryopreserve Mustelidae embryos or cells, and to enhance the number of live offspring from cryopreserved Mustelidae embryos.
    Type: Application
    Filed: March 4, 2009
    Publication date: September 24, 2009
    Applicant: University of Iowa Research Foundation
    Inventors: Xingshen Sun, Yaling Yi, Gregory H. Leno, John F. Engelhardt, Ziying Yan, Michael J. Welsh, Chris Rogers
  • Transgenic animal models of disease
    Publication number: 20090241203
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of making and using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Application
    Filed: September 17, 2008
    Publication date: September 24, 2009
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall Prather, John Engelhardt, Ziying Yan
  • Transgenic animal models of disease
    Publication number: 20090235368
    Abstract: The present invention provides transgenic, large non-human animal models of diseases and conditions, as well as methods of using such animal models in the identification and characterization of therapies for the diseases and conditions.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 17, 2009
    Inventors: Michael J. Welsh, Christopher S. Rogers, Randall Prather, John Englehardt, Ziying Yan
  • Compounds and methods to enhance rAAV transduction
    Publication number: 20080249050
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Application
    Filed: August 7, 2007
    Publication date: October 9, 2008
    Inventors: John F. Engelhardt, Keith L. Munson, Ziying Yan
  • Adeno-associated viruses and uses thereof
    Publication number: 20080226600
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Application
    Filed: August 7, 2007
    Publication date: September 18, 2008
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Adeno-associated viruses and uses thereof
    Publication number: 20080166758
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Application
    Filed: June 21, 2007
    Publication date: July 10, 2008
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Adeno-associated virus vectors and uses thereof
    Patent number: 7241447
    Abstract: The invention provides an isolated and purified DNA molecule comprising at least one DNA segment, a biologically active subunit or variant thereof, of a circular intermediate of adeno-associated virus, which DNA segment confers increased episomal stability, persistence or abundance of the isolated DNA molecule in a host cell. The invention also provides a composition comprising at least two adeno-associated virus vectors.
    Type: Grant
    Filed: October 6, 2000
    Date of Patent: July 10, 2007
    Assignee: University of Iowa Research Foundation
    Inventors: John F. Engelhardt, Dongsheng Duan, Ziying Yan
  • Compounds and methods to enhance rAAV transduction
    Publication number: 20050037497
    Abstract: Agents and methods to alter rAAV transduction are provided.
    Type: Application
    Filed: March 31, 2004
    Publication date: February 17, 2005
    Inventors: John Engelhardt, Keith Munson, Ziying Yan
  • Adeno-associated virus vectors with intravector heterologous terminal palindromic sequences
    Publication number: 20040248301
    Abstract: The invention provides recombinant AAV vectors, at least one of which has heterologous terminal palindromic sequences, and methods of using those vectors.
    Type: Application
    Filed: April 30, 2004
    Publication date: December 9, 2004
    Inventors: John F. Engelhardt, Ziying Yan
  • Pseudotyped adeno-associated viruses and uses thereof
    Publication number: 20030103939
    Abstract: Pseudotyped rAAV and methods of using pseudotyped rAAV are provided.
    Type: Application
    Filed: July 12, 2002
    Publication date: June 5, 2003
    Inventors: John F. Engelhardt, Ziying Yan