Abstract: The present disclosure provides a cell segmentation and typing method, device, apparatus and medium based on machine learning. The method includes: acquiring at least one cell metabolism image of a target object; performing single cell image segmentation on the at least one cell metabolism image by using a machine learning segmentation model to obtain a plurality of single cell metabolism images; performing single cell feature extraction on each single cell metabolism image of the plurality of single cell metabolism images to obtain a single cell image feature map corresponding to the single cell metabolism image; combining the single cell image feature map corresponding to each single cell metabolism image of the plurality of single cell metabolism images to obtain an image feature map of the target object; performing typing of the cell by clustering the image feature map of the target object.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: Disclosed is a computer-implemented method for sequence design, including: obtaining a candidate target sequence set that translates into a source sequence, based on the source sequence; and searching in the candidate target sequence set for a desired target sequence having a sequence structure that minimizes an objective function. The objective function comprises a minimum free energy (MFE) of a candidate target sequence and an additive regularization term.

Abstract: The present invention discloses an ultralow-power negative margin timing monitoring method of a neural network circuit, relates to an adaptive voltage regulation technology based on on-chip timing detection, and belongs to the technical field of low-power design of integrated circuit. The present invention provides an ultralow-power operating method of neural network circuit. By inserting a timing monitoring unit in specific position of critical paths and setting partial circuits to operate under “negative margin”, the system can further lower voltage, compress the timing slack, and obtain higher power gain.

Abstract: The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: Embodiments of the present disclosure provide a video processing method, an apparatus and a device. The method includes: receiving a video generating request; acquiring a video template according to the video generating request, where the video template includes a plurality of placeholders, where each of the placeholders is configured to indicate at least one of a text type, an image type and a video type; acquiring a plurality of materials according to the video generating request, where types of the plurality of the materials include at least one of a text type, an image type and a video type; based on the types of the materials, importing the plurality of the materials into positions of corresponding placeholders in the video template respectively and performing rendering to obtain a synthesized video.

Abstract: A biochemical test strip tube comprises a tube portion and a cover portion. The tube portion comprises a solution chamber and a test strip fixing member which has a horizontal spacing between its outer edge and an inner wall of the tube portion. When the cover portion seals off the tube portion, a top of the solution chamber communicates with a top of the test strip fixing member, and a horizontal spacing is provided between an outer edge of the test strip fixing member and an inner wall of the cover portion. Due to the horizontal spacing between the test paper fixing member and the inner wall of the tube portion, the biochemical test strip does not contact or form a wall against the inner wall of the tube portion to avoid affecting the detection effect when the biochemical test strip is provided inside the test strip fixing member.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: The present disclosure provides novel piperidine- and guanosine-derived ligands that bind specifically to asialoglycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs.

Abstract: The present invention provides molecules comprising a modified Fc region which do not mediate antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) but maintain a long serum half-life due to binding to the neonetal Fc receptor (FcRn). To this end, the molecules of the present invention do not comprise the disulfide bridges of the antibody hinge region but are linked C-terminally by at least two covalent bonds. Furthermore, the molecules of the present invention comprise CH2 domains with an additional disulfide bond.

Abstract: The present disclosure provides a method for wet removal of sulfur dioxide by silicate bacteria-enhanced pulp. The method includes: treatment of ore waste residue, activation and domestication of silicate bacteria, preparation of pulp, removal of sulfur dioxide, and resource utilization of a desulfurization product. The present disclosure combines flue gas desulfurization with resource utilization of the ore waste residue, and improves a desulfurization efficiency of the method by the pulp and a utilization rate of ore waste residue resources through silicate bacteria. The present disclosure has a high desulfurization efficiency, simple production process, and low cost, and realizes the recycling of resources such as the ore waste residue, the sulfur dioxide, and silicon. The present disclosure has obvious economic and environmental benefits and broad prospects for use.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: New peptides as selective GIP receptor agonists The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: Described herein is an immobilization-free, electrochemical method of detecting a target DNA sequence in a sample. The method includes: incubating the sample with a detection mixture, applying an electric field including an alternating current electric field and a direct current offset to the detection mixture to concentrate nucleic acids in the sample and the nucleic acid probe on a positively charged working electrode, wherein a Class 2 Cas protein trans-cleaved electroactive probe is released from the nucleic acid probe when the target DNA is present in the sample and diffuses toward a negatively charged electrode; and measuring the current as potential is applied, wherein detection of a current in the detection mixture indicates the presence of the target DNA sequence in the sample.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: A messenger RNA (mRNA) vaccine has emerged as a promising direction to combat the COVID-19 pandemic. This requires an mRNA sequence that is stable and highly productive in protein expression, features to benefit from greater mRNA secondary structure folding stability and optimal codon usage. Sequence design remains challenging due to the exponentially many synonymous mRNA sequences encoding the same protein. The present disclosure presents embodiments of a linear-time approximation (LinearDesign) reducing the design to an intersection between a Stochastic Context Free Grammar (SCFG) and a Deterministic Finite Automaton (DFA). Embodiments of the LinearDesign may implement an mRNA sequence design using much reduced time with very limited loss. Various methodologies, e.g., finding alternative sequences based on k-best parsing or directly incorporating codon optimality, are presented for incorporating the codon optimality into the design.

Abstract: An alloy having formula (Fe1-xCox)100-y-z-aByCuzMa, in which x=0.1-0.4, y=10-16, z=0-1, a=0-8, and M=Nb, Mo, Ta, W, Ni, or Sn, wherein the alloy has crystalline grains with an average size of 30 nm or less.

Abstract: The invention discloses a method for designing composite-index agricultural insurance and a product therefrom, the method including: S1, Obtaining the required data in the study area; S2, Constructing the climatic simulation scenarios under ideal and disaster, S3, Calibrating the site-level crop growth model, then inputting the simulation scenarios of S2 to get the corresponding output of each site; S4, Calculating the premium rate of agricultural insurance based on the output of S3; S5, Choosing several candidate indicators and using these indicators to construct a composite index; S6, Building a vulnerability model that reflects the response between the yield loss rate and the composite index through combining the composite index of S5 with the output of S3, then determine how to pay out based on the vulnerability model and the premium rate.

Abstract: The present invention discloses an ultralow-power negative margin timing monitoring method of a neural network circuit, relates to an adaptive voltage regulation technology based on on-chip timing detection, and belongs to the technical field of low-power design of integrated circuit. The present invention provides an ultralow-power operating method of neural network circuit. By inserting a timing monitoring unit in specific position of critical paths and setting partial circuits to operate under “negative margin”, the system can further lower voltage, compress the timing slack, and obtain higher power gain.