Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: The present disclosure provides novel piperidine- and guanosine-derived ligands that bind specifically to asialoglycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs.

Abstract: A system and method for changing an overall style of a public area based on a virtual scene are provided. The system includes: an information storage module configured to store user profile information, user interaction and operation information, and interior style information on a computer host or a cloud server; a scene rendering module configured to obtain data in the information storage module and present panorama information of a public area to a user through a real-time rendering system; a style interaction module configured to change overall style information attached to a structure to implement ideas of different users for the public area in real time; and a control module configured to change and record style information in a virtual scene and provide roaming experience in the public area.

Abstract: The present invention provides molecules comprising a modified Fc region which do not mediate antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) but maintain a long serum half-life due to binding to the neonetal Fc receptor (FcRn). To this end, the molecules of the present invention do not comprise the disulfide bridges of the antibody hinge region but are linked C-terminally by at least two covalent bonds. Furthermore, the molecules of the present invention comprise CH2 domains with an additional disulfide bond.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: New peptides as selective GIP receptor agonists The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: A messenger RNA (mRNA) vaccine has emerged as a promising direction to combat the COVID-19 pandemic. This requires an mRNA sequence that is stable and highly productive in protein expression, features to benefit from greater mRNA secondary structure folding stability and optimal codon usage. Sequence design remains challenging due to the exponentially many synonymous mRNA sequences encoding the same protein. The present disclosure presents embodiments of a linear-time approximation (LinearDesign) reducing the design to an intersection between a Stochastic Context Free Grammar (SCFG) and a Deterministic Finite Automaton (DFA). Embodiments of the LinearDesign may implement an mRNA sequence design using much reduced time with very limited loss. Various methodologies, e.g., finding alternative sequences based on k-best parsing or directly incorporating codon optimality, are presented for incorporating the codon optimality into the design.

Abstract: An alloy having formula (Fe1-xCox)100-y-z-aByCuzMa, in which x=0.1-0.4, y=10-16, z=0-1, a=0-8, and M=Nb, Mo, Ta, W, Ni, or Sn, wherein the alloy has crystalline grains with an average size of 30 nm or less.

Abstract: The present invention discloses an ultralow-power negative margin timing monitoring method of a neural network circuit, relates to an adaptive voltage regulation technology based on on-chip timing detection, and belongs to the technical field of low-power design of integrated circuit. The present invention provides an ultralow-power operating method of neural network circuit. By inserting a timing monitoring unit in specific position of critical paths and setting partial circuits to operate under “negative margin”, the system can further lower voltage, compress the timing slack, and obtain higher power gain.

Abstract: An electric pressure cooker having a safety switch device. The electric pressure cooker includes a cooker body and a lid; wherein the cooker body is provided with a push rod vertically reciprocating relative to the cooker body; the cooker body is further provided with a microswitch; a driving rod of the microswitch horizontally reciprocates relative to the cooker body; after the push rod moves downward, the driving rod of the microswitch is pushed to trigger the microswitch by the push rod; after the push rod moves upward, the driving rod of the microswitch is detached from the push rod; an upper end of the push rod abuts against the lid and the push rod moves upward and downward with rotation of the lid to detach from and push the push rod of the microswitch; and the microswitch is electrically connected to a circuitry of the electric pressure cooker.

Abstract: An electric pressure cooker having a safety switch device. The electric pressure cooker includes a cooker body and a lid; wherein the cooker body is provided with a push rod vertically reciprocating relative to the cooker body; the cooker body is further provided with a microswitch; a driving rod of the microswitch horizontally reciprocates relative to the cooker body; after the push rod moves downward, the driving rod of the microswitch is pushed to trigger the microswitch by the push rod; after the push rod moves upward, the driving rod of the microswitch is detached from the push rod; an upper end of the push rod abuts against the lid and the push rod moves upward and downward with rotation of the lid to detach from and push the push rod of the microswitch; and the microswitch is electrically connected to a circuitry of the electric pressure cooker.

Abstract: The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation.

Abstract: The present invention provides novel phenalenone derivatives of formula (I) which are formed by the microorganism Penicillium herquei Bainer & Sartory, DSM 14142, during fermentation. A process for their preparation, their use as pharmaceutical compositions, and their use for the treatment or prophylaxis of bacterial infections, mycoses, oncoses and rheumatic diseases are also disclosed and claimed.

Abstract: The invention relates to compounds of formula I and of formula II in which R1, R2, R3, R4, R5, X1, X2, X3, X4, X5 and Y are defined in the specification. The compounds of formulae I and II inhibit cyclin-dependent kinases (CDKS) and other kinases (KDR), have cytostatic actions, and are suitable for treating tumors. The compounds of formulae I and II are obtainable by extracting the plant Uvaria klaineri, PLA 100484, by cell cultures of the plant Uvaria klaineri, or by chemical synthesis. The invention relates to a method for preparing the compounds of formulae I and II, to the use of the compounds for producing a pharmaceutical for the treatment of malignant disorders and of diseases which may be treated by inhibition of CDKs and KDR, and also to pharmaceutical compositions comprising at least one compound of the formula I or II.

Abstract: The invention relates to compounds of formula I 1