Abstract: The present invention provides a helicase BCH2X, comprising an amino acid sequence represented by any one of SEQ ID NOs: 1-3. The present invention also provides a complex structure comprising the helicase BCH2X and a binding moiety for binding polynucleotides. The present invention also provides a use of the helicase BCH2X or the complex structure comprising same in the control and characterization of polynucleotides and single-molecule nanopore sequencing.

Abstract: Provided is helicase BCH1X, which comprises an amino acid sequence represented by SEQ ID NO: 1 or 2. Further provided are a complex structure comprising helicase BCH1X and a binding moiety used for binding to a polynucleotide, and a use thereof in the control and characterization of a polynucleotide and in single molecule nanopore sequencing.

Abstract: The present disclosure provides a cell segmentation and typing method, device, apparatus and medium based on machine learning. The method includes: acquiring at least one cell metabolism image of a target object; performing single cell image segmentation on the at least one cell metabolism image by using a machine learning segmentation model to obtain a plurality of single cell metabolism images; performing single cell feature extraction on each single cell metabolism image of the plurality of single cell metabolism images to obtain a single cell image feature map corresponding to the single cell metabolism image; combining the single cell image feature map corresponding to each single cell metabolism image of the plurality of single cell metabolism images to obtain an image feature map of the target object; performing typing of the cell by clustering the image feature map of the target object.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: Disclosed is a computer-implemented method for sequence design, including: obtaining a candidate target sequence set that translates into a source sequence, based on the source sequence; and searching in the candidate target sequence set for a desired target sequence having a sequence structure that minimizes an objective function. The objective function comprises a minimum free energy (MFE) of a candidate target sequence and an additive regularization term.

Abstract: The present invention discloses an ultralow-power negative margin timing monitoring method of a neural network circuit, relates to an adaptive voltage regulation technology based on on-chip timing detection, and belongs to the technical field of low-power design of integrated circuit. The present invention provides an ultralow-power operating method of neural network circuit. By inserting a timing monitoring unit in specific position of critical paths and setting partial circuits to operate under “negative margin”, the system can further lower voltage, compress the timing slack, and obtain higher power gain.

Abstract: The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: Embodiments of the present disclosure provide a video processing method, an apparatus and a device. The method includes: receiving a video generating request; acquiring a video template according to the video generating request, where the video template includes a plurality of placeholders, where each of the placeholders is configured to indicate at least one of a text type, an image type and a video type; acquiring a plurality of materials according to the video generating request, where types of the plurality of the materials include at least one of a text type, an image type and a video type; based on the types of the materials, importing the plurality of the materials into positions of corresponding placeholders in the video template respectively and performing rendering to obtain a synthesized video.

Abstract: An antibody that specifically binds to IL-1R3, comprising an antibody heavy chain amino acid sequence of SEQ ID NO: 1 and a light chain amino acid sequence of SEQ ID NO: 2. A pharmaceutical composition is provided comprising the said antibody and a pharmaceutically acceptable diluent, carrier or excipient. Also said antibody for use in treating a disease or disorder in a subject in need thereof. The disease or disorder may be an autoimmune or autoinflammatory disease or disorder.

Abstract: The present disclosure provides novel piperidine- and guanosine-derived ligands that bind specifically to asialoglycoprotein receptor (ASGPR) and nucleotide analogs conjugated thereto that can be incorporated into oligonucleotides, including double-stranded oligonucleotides such as siRNAs.

Abstract: The present invention provides molecules comprising a modified Fc region which do not mediate antibody effector functions such as antibody-dependent cellular cytotoxicity (ADCC) but maintain a long serum half-life due to binding to the neonetal Fc receptor (FcRn). To this end, the molecules of the present invention do not comprise the disulfide bridges of the antibody hinge region but are linked C-terminally by at least two covalent bonds. Furthermore, the molecules of the present invention comprise CH2 domains with an additional disulfide bond.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: New peptides as selective GIP receptor agonists The present invention relates to peptidic selective GIP receptor agonists and their medical use, for example in the treatment of disorders of the metabolic syndrome, including diabetes and obesity, hyperglycemia, as well as the treatment of disorders associated with nausea and vomiting.

Abstract: A method and an apparatus for processing a three-dimensional video, a readable storage medium and an electronic device are involved in the present disclosure, and the present disclosure relates to the field of electronic information technologies. The method is applied to a terminal device, and includes: sending an initial two-dimensional image to a server, so that the server generates an initial three-dimensional video according to the initial two-dimensional image; receiving the initial three-dimensional video sent by the server, and processing the initial three-dimensional video to obtain a target three-dimensional video. According to the present disclosure, a two-dimensional image on the terminal device is uploaded to the server and is converted into a three-dimensional video by the server, then the three-dimensional video is processed by the terminal device.

Abstract: A messenger RNA (mRNA) vaccine has emerged as a promising direction to combat the COVID-19 pandemic. This requires an mRNA sequence that is stable and highly productive in protein expression, features to benefit from greater mRNA secondary structure folding stability and optimal codon usage. Sequence design remains challenging due to the exponentially many synonymous mRNA sequences encoding the same protein. The present disclosure presents embodiments of a linear-time approximation (LinearDesign) reducing the design to an intersection between a Stochastic Context Free Grammar (SCFG) and a Deterministic Finite Automaton (DFA). Embodiments of the LinearDesign may implement an mRNA sequence design using much reduced time with very limited loss. Various methodologies, e.g., finding alternative sequences based on k-best parsing or directly incorporating codon optimality, are presented for incorporating the codon optimality into the design.

Abstract: An alloy having formula (Fe1-xCox)100-y-z-aByCuzMa, in which x=0.1-0.4, y=10-16, z=0-1, a=0-8, and M=Nb, Mo, Ta, W, Ni, or Sn, wherein the alloy has crystalline grains with an average size of 30 nm or less.

Abstract: The present invention discloses an ultralow-power negative margin timing monitoring method of a neural network circuit, relates to an adaptive voltage regulation technology based on on-chip timing detection, and belongs to the technical field of low-power design of integrated circuit. The present invention provides an ultralow-power operating method of neural network circuit. By inserting a timing monitoring unit in specific position of critical paths and setting partial circuits to operate under “negative margin”, the system can further lower voltage, compress the timing slack, and obtain higher power gain.

Abstract: An electric pressure cooker having a safety switch device. The electric pressure cooker includes a cooker body and a lid; wherein the cooker body is provided with a push rod vertically reciprocating relative to the cooker body; the cooker body is further provided with a microswitch; a driving rod of the microswitch horizontally reciprocates relative to the cooker body; after the push rod moves downward, the driving rod of the microswitch is pushed to trigger the microswitch by the push rod; after the push rod moves upward, the driving rod of the microswitch is detached from the push rod; an upper end of the push rod abuts against the lid and the push rod moves upward and downward with rotation of the lid to detach from and push the push rod of the microswitch; and the microswitch is electrically connected to a circuitry of the electric pressure cooker.