Patents by Inventor Ziyuan Zhou

Ziyuan Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11325901
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: May 10, 2022
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20220081432
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Application
    Filed: November 30, 2021
    Publication date: March 17, 2022
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20220031709
    Abstract: Disclosed methods of inhibiting microsomal prostaglandin E2 (PGE2) synthase-1 (mPGES-1) make use of ceftriaxone, aztreonam, cefotetan, pharmaceutically-acceptable salts thereof, and combinations thereof.
    Type: Application
    Filed: August 3, 2021
    Publication date: February 3, 2022
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou
  • Patent number: 11220497
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Grant
    Filed: June 28, 2017
    Date of Patent: January 11, 2022
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Patent number: 11103509
    Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.
    Type: Grant
    Filed: November 6, 2019
    Date of Patent: August 31, 2021
    Assignee: University of Kentucky Research Foundation
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou
  • Publication number: 20210114909
    Abstract: The invention provides a method for preparing strontium-rich mineral water from distilled water obtained in the salt production process from brine, which comprises the following steps: carrying out aeration pretreatment on the salt-making distilled water to obtain pretreated distilled water, and further performing sand filtration, ion exchange, activated carbon, membrane filtration and sterilization and disinfection treatment on the pretreated distilled water to obtain the drinking strontium-rich mineral water with the strontium element content of more than 0.4 mg/L.
    Type: Application
    Filed: October 22, 2020
    Publication date: April 22, 2021
    Inventors: Xuebing ZHAO, Dehua LIU, Ziyuan ZHOU, Lingmei DAI, Chenghua ZOU
  • Publication number: 20210114910
    Abstract: The invention provides a method for preparing drinking weak alkali water and strontium-rich electrolyte raw water from distilled water obtained in the process of producing salt from well and mine brine, which comprises procedures of pressure reduction treatment, primary filtration, membrane separation treatment, activated carbon adsorption treatment, secondary filtration treatment, sterilization and disinfection treatment and the like on the salt-making distilled water in sequence so as to remove insoluble solid impurities, sulfides, microorganisms and other substances in the raw water, and separate or enrich ions, thereby preparing the weak alkali water suitable for drinking and the strontium-rich electrolyte raw water capable of being used for functional beverage production. The method provided by the invention can not only realize the comprehensive utilization of resources, but also obtain new products, significantly improving the economical efficiency of the process.
    Type: Application
    Filed: October 22, 2020
    Publication date: April 22, 2021
    Inventors: Xuebing ZHAO, Dehua LIU, Ziyuan ZHOU, Lingmei DAI, Chenghua ZOU
  • Publication number: 20200231583
    Abstract: Compounds and compositions are provided that can inhibit microsomal prostaglandin E synthase-1 (mPGES-1). The compounds and compositions can reduce inflammation in a subject, such as inflammation caused by an inflammation disorder or symptoms thereof. Pharmaceutical compositions comprising the compound are also provided. Furthermore, methods are provided for reducing inflammation and/or inhibiting mPGES-1. The methods can comprise administering an effective amount of the composition to a subject.
    Type: Application
    Filed: June 28, 2017
    Publication date: July 23, 2020
    Inventors: Chang-Guo Zhan, Fang Zheng, Kai Ding, Ziyuan Zhou
  • Publication number: 20200138818
    Abstract: A method of treating pain is disclosed, which involves administering an effective amount of lapatinib or a pharmaceutically-acceptable salt thereof to a subject in need of treatment for pain.
    Type: Application
    Filed: November 6, 2019
    Publication date: May 7, 2020
    Inventors: Chang-Guo Zhan, Fang Zheng, Shuo Zhou, Ziyuan Zhou