Patents by Inventor Zoë JOHNSON

Zoë JOHNSON has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PI3K-? inhibitor for use in treatment regimens
    Patent number: 12605389
    Abstract: A compound or a pharmaceutically acceptable salt thereof for use in a method of treatment of a disease or condition in which signalling through the PI3K? pathway is pathologically implicated in patients, for example cancer and inflammatory or autoimmune diseases. The compound is provided at a specified dose and has been found to have a favourable safety profile in humans, in particular with regard to hepatotoxicity, diarrhoea/colitis, respiratory infections, and hematologic toxicities.
    Type: Grant
    Filed: March 29, 2022
    Date of Patent: April 21, 2026
    Assignee: iOnctura SA
    Inventors: Catherine Pickering, Lars Van Der Veen, Michael Lahn, Rebeca Zorrilla, Zoë Johnson
  • AUTOTAXIN (ATX) INHIBITOR FOR THE TREATMENT OF PANCREATIC CANCER
    Publication number: 20250057820
    Abstract: An autotaxin (ATX) inhibitor or a pharmaceutically acceptable salt thereof for use in a method of treatment of pancreatic cancer in a patient, optionally wherein the method further comprises administration of a TGF-? pathway inhibitor and/or an additional chemotherapeutic agent.
    Type: Application
    Filed: June 8, 2022
    Publication date: February 20, 2025
    Inventors: Zoë JOHNSON, Marcel DEKEN, Michael LAHN, Davide MELISI
  • A PI3K-DELTA INHIBITOR FOR THE TREATMENT OF PANCREATIC CANCER
    Publication number: 20240216385
    Abstract: A PI3K-delta inhibitor or a pharmaceutically acceptable salt thereof for use in a method of treatment of pancreatic cancer in a patient, optionally wherein the method further comprises administration of an autotaxin (ATX) inhibitor or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: March 29, 2022
    Publication date: July 4, 2024
    Inventors: Zoë JOHNSON, Karolina NIEWOLA-STASZKOWSKA, Lars VAN DER VEEN, Georgia KONSTANTINIDOU
  • ANTI-CD73 ANTIBODIES
    Publication number: 20240117065
    Abstract: This invention relates to anti-CD73 antibody molecules that include a VH domain comprising a VHCDR1 of SEQ ID NO: 1, a VHCDR2 of SEQ ID NO: 2, and a VHCDR3 of SEQ ID NO: 3; and a VL domain comprising a VLCDR1 of SEQ ID NO: 4, a VLCDR2 of SEQ ID NO: 5, and a VLHCDR3 of SEQ ID NO: 6. Antibody molecules and methods for their production and use in therapy, for example for treating cancer or reducing tumor-mediated immunosuppression are provided.
    Type: Application
    Filed: April 8, 2022
    Publication date: April 11, 2024
    Inventors: Lorna STEWART, Grainne GERNON, Zoë JOHNSON, Marcel DEKEN
  • A PI3K-DELTA INHIBITOR FOR USE IN TREATMENT REGIMENS
    Publication number: 20240058351
    Abstract: A compound or a pharmaceutically acceptable salt thereof for use in a method of treatment of a disease or condition in which signalling through the PI3K? pathway is pathologically implicated in patients, for example cancer and inflammatory or autoimmune diseases. The compound is provided at a specified dose and has been found to have a favourable safety profile in humans, in particular with regard to hepatotoxicity, diarrhoea/colitis, respiratory infections, and hematologic toxicities.
    Type: Application
    Filed: March 29, 2022
    Publication date: February 22, 2024
    Inventors: Catherine PICKERING, Lars VAN DER VEEN, Michael LAHN, Rebeca ZORRILLA, Zoë JOHNSON